Radioactive seed migration to the chest after transperineal interstitial prostate brachytherapy: extraprostatic seed placement correlates with migration
Originally presented at the 43rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology, November 2001.
Received 26 June 2003; accepted 15 October 2003.
Abstract
Purpose
To examine the incidence of seed migration detected on chest X-ray and to identify the predictors associated with its occurrence.
Methods and materials
Between May 1998 and April 2000, 102 patients underwent permanent prostate brachytherapy at our institution and 100 were eligible for the study. Chest X-rays obtained at follow-up were examined for the number and location of seeds. The patient and treatment variables potentially associated with the occurrence and number of seed migrations were analyzed.
Results
One or more seeds were identified on the chest X-rays of 55 (55%) of 100 patients. The mean number of intrathoracic seeds in patients with migration was 2.2 (range, 1–10), and the proportion of seeds that migrated to the thorax was 0.98%. The rate of extraprostatic seeds planned was 43.9%, and postimplant CT identified 37.9% in such a location. The number of seeds planned for extraprostatic placement and below the apex were statistically significant (α = 0.05) predictors in univariate logistic analysis. Multivariate analysis revealed the planned number of extraprostatic seeds as the only statistically significant predictor (p = 0.04).
Conclusion
Extraprostatic placement of loose seeds is associated with an increased likelihood for, and frequency of, seed migration to the thorax. Nonetheless, the small proportion of implanted seeds that migrated (≤1%) is highly unlikely to have significant dosimetric consequences.
*Division of Radiation Oncology, Mayo Clinic, Rochester, MN, USA
†Department of Urology, Mayo Clinic, Rochester, MN, USA
‡Department of Diagnostic Radiology, Mayo Clinic, Rochester, MN, USA
§Division of Biostatistics, Mayo Clinic, Rochester, MN, USA
Reprint requests to: Brian J. Davis, M.D., Ph.D., Division of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA. Tel: (507) 284-3191; Fax: (507) 284-0079
ABSTRACT