International Journal of Radiation Oncology * Biology * Physics
Volume 48, Issue 4 , Pages 919-922 , 1 November 2000

Pancreatic tumors show high levels of hypoxia

Presented at the American Society of Clinical Oncologists Annual Meeting, New Orleans, LA (USA), May 20–23, 2000.

  • Albert C Koong, M.D., Ph.D.

      Affiliations

    • Co-First Authors. Both individuals contributed equally to the conception, design, execution, and data analysis of this project.
    • Department Radiation Oncology, Stanford University Medical Center, Stanford, CA, USA
    • Co-First Authors. Both individuals contributed equally to the conception, design, execution, and data analysis of this project.
    • Corresponding Author InformationReprint request to: Dr. Albert C. Koong, Department of Radiation Oncology, MC5302, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305
    • ,
  • Vivek K Mehta, M.D.

      Affiliations

    • Co-First Authors. Both individuals contributed equally to the conception, design, execution, and data analysis of this project.
    • Department Radiation Oncology, Stanford University Medical Center, Stanford, CA, USA
    • Co-First Authors. Both individuals contributed equally to the conception, design, execution, and data analysis of this project.
    • ,
  • Quynh T Le, M.D.

      Affiliations

    • Department Radiation Oncology, Stanford University Medical Center, Stanford, CA, USA
    • ,
  • George A Fisher, M.D., Ph.D.

      Affiliations

    • Department of Medicine, Stanford University Medical Center, Stanford, CA, USA
    • ,
  • David J Terris, M.D.

      Affiliations

    • Department of Otolaryngology, Stanford University Medical Center, Stanford, CA, USA
    • ,
  • J.Martin Brown, Ph.D.

      Affiliations

    • Department Radiation Oncology, Stanford University Medical Center, Stanford, CA, USA
    • ,
  • Augusto J Bastidas, M.D.

      Affiliations

    • Department of Surgery, Stanford University Medical Center, Stanford, CA, USA
    • ,
  • Mark Vierra, M.D.

      Affiliations

    • Department of Surgery, Stanford University Medical Center, Stanford, CA, USA

,Accepted 25 July 2000.

References 

  1. Hall E. Radiobiology for the radiobiologist. 3rd ed. Philadelphia: Lippincott; 1988 p. 137–160.
  2. Graeber T, Osmanian C, Jacks T, et al.  Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature. 1996;379:88–91
  3. Rampling R, Cruickshank G, Lewis AD, et al.  Direct measurements of pO2 distribution and bioreductive enzymes in human malignant brain tumors. Int J Radiat Oncol Biol Phys. 1994;29:427–431
  4. Brizel DM, Scully SP, Harrelson JM; et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. 1996;56(5):941–943.
  5. Nordsmark M, Overgaard M, Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol. 1996;41(1):31–39
  6. Okunieff P, Hockel M, Dunphy EP, et al.  Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone. Int J Radiat Oncol Biol Phys. 1993;26(4):631–636
  7. Hockel M, Knoop C, Schlenger K, et al.  Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol. 1993;26:45–50
  8. Fyles AW, Milosevic M, Wong R, et al.  Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol. 1998;48(2):149–156
  9. Movsas B, Chapman JP, Horrowitz EM, et al.  Hypoxic regions exist in human prostate carcinoma. Urology. 1999;53(1):11–18
  10. Bastidas JA, Poen JC, Niederhuber JE. Pancreas. In:  Abeloff MD,  Armitage JO,  Lichter AS,  Niederhuber JE editor. Clinical oncology. 2nd ed.. Philadelphia: Churchill-Livingstone; 2000;p. 1749–1783
  11. Gastrointestinal Tumor Study Group . Therapy of locally unresectable pancreatic carcinoma (A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil). Cancer. 1981;48:1705–1710
  12. Thomlinson RH, Gray LH. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer. 1955;9:539–549
  13. Hockel M, Schlerser K, Aral B, et al.  Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 1996;56(19):4509–4515
  14. Brown JM, Giaccia AJ. The unique physiology of solid tumors (opportunities (and problems) for cancer therapy). Cancer Res. 1998;58(7):1408–1416
  15. Koong AC, Denko NC, Hudson KM, et al.  Candidate genes for the hypoxic tumor phenotype. Cancer Res. 2000;60:883–887

PII: S0360-3016(00)00803-8

International Journal of Radiation Oncology * Biology * Physics
Volume 48, Issue 4 , Pages 919-922 , 1 November 2000

Article Tools

* Image Usage & Resolution