International Journal of Radiation Oncology * Biology * Physics
Volume 50, Issue 5 , Pages 1172-1180 , 1 August 2001

Treatment results and prognostic factors of advanced T3–4 laryngeal carcinoma: the University of California, San Francisco (UCSF) and Stanford University Hospital (SUH) experience

Presented at the Annual Meeting of the Radiological Society of North America (RSNA), Chicago, IL, November 26, 2000.

  • Phuc F Nguyen-Tan, M.D.C.M.

      Affiliations

    • Department of Radiation Oncology, University of California, San Francisco, CA, USA
    • Corresponding Author InformationReprint requests to: Dr. Phuc F. Nguyen-Tan, Department of Radiation Oncology, Hôpital Notre-Dame, 1560 Sherbrooke Street East, Montreal, Quebec, Canada, H2L 4M1
    • ,
  • Quynh-Thu Le, M.D.

      Affiliations

    • Department of Radiation Oncology, Stanford University, Stanford, CA, USA
    • ,
  • Jeanne-Marie Quivey, M.D.

      Affiliations

    • Department of Radiation Oncology, University of California, San Francisco, CA, USA
    • ,
  • Mark Singer, M.D.

      Affiliations

    • Department of Otolaryngology, University of California, San Francisco, CA, USA
    • ,
  • David J Terris, M.D.

      Affiliations

    • Department of Otolaryngology, Stanford University, Stanford, CA, USA
    • ,
  • Don R Goffinet, M.D.

      Affiliations

    • Department of Radiation Oncology, Stanford University, Stanford, CA, USA
    • ,
  • Karen K Fu, M.D.

      Affiliations

    • Department of Radiation Oncology, University of California, San Francisco, CA, USA

,Accepted 21 February 2001.

References 

  1. Goh C, O’Sullivan B, Warde P, et al.  Multidisciplinary management controversies in laryngeal cancer. Ann Acad Med Singapore. 1996;25:405–412
  2. O’Sullivan B, Mackillop W, Gilbert R, et al.  Controversies in the management of laryngeal cancer (Results of an international survey of patterns of care). Radiother Oncol. 1994;31:23–32
  3. Harari PM. Why has induction chemotherapy for advanced head and neck cancer become a United States community standard of practice?. J Clin Oncol. 1997;15:2050–2055
  4. Fleming R, Cooper J, Henson D, et al. American Joint Committee on Cancer staging manual. 5th ed. Philadelphia, PA: Lippincott-Raven; 1997. p. 41–46.
  5. Kaplan EL, Meier P. Non-Parametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–461
  6. Cox D. Regression models and life-tables. J Roy Stat Soc. 1972;34:187–220
  7. Fisher RA. Statistical methods for research workers. 13th ed. New York: Hafner; 1958. p. 96–97.
  8. Statistics with Stata, Version 3.1: Computing Resource Center; 1992.
  9. Yuen A, Medina JE, Goepfert H, et al.  Management of stage T3 and T4 glottic carcinomas. Am J Surg. 1984;148:467–472
  10. Woodhouse RJ, Quivey JM, Fu KK, et al.  Treatment of carcinoma of the vocal cord. A review of 20 years experience. Laryngoscope. 1981;91:1155–1162
  11. Razack MS, Maipang T, Sako K, et al.  Management of advanced glottic carcinomas. Am J Surg. 1989;158:318–320
  12. Kowalski LP, Batista MB, Santos CR, et al.  Prognostic factors in T3, N0–1 glottic and transglottic carcinoma. A multifactorial study of 221 cases treated by surgery or radiotherapy. Arch Otolaryngol Head Neck Surg. 1996;122:77–82
  13. Jones AS, Cook JA, Philipps DE, et al.  Treatment of T3 carcinoma of the larynx by surgery or radiotherapy. Clin Otolaryngol. 1992;17:433–436
  14. Brady LW, Markoe AM, Fisher SA, et al.  Cancer cure with organ preservation using radiation therapy. Acta Oncol. 1988;27:195–202
  15. Bryant GP, Poulsen MG, Tripcony L, et al.  Treatment decisions in T3N0M0 glottic carcinoma. Int J Radiat Oncol Biol Phys. 1995;31:285–293
  16. Croll GA, Gerristen GJ, Tiwari RM, et al.  Primary radiotherapy with surgery in reserve for advanced laryngeal carcinoma. Results and complications. Eur J Surg Oncol. 1989;15:350–356
  17. Freeman DE, Mancuso AA, Parsons JT, et al.  Irradiation alone for supraglottic carcinoma (Can CT findings predict treatment results?). Int J Radiat Oncol Biol Phys. 1990;19:485–490
  18. Harwood AR, Hawkins NV, Beale FA, et al.  Management of advanced glottic cancer. A 10 year review of the Toronto experience. Int J Radiat Oncol Biol Phys. 1979;5:899–904
  19. Harwood AR, Beale FA, Cummings BJ, et al.  Supraglottic laryngeal carcinoma (An analysis of dose-time volume factors in 410 patients). Int J Radiat Oncol Biol Phys. 1983;9:311–319
  20. MacKenzie RG, Franssen E, Balogh JM, et al.  Comparing treatment outcomes of radiotherapy and surgery in locally advanced carcinoma of the larynx (A comparison limited to patients eligible for surgery). Int J Radiat Oncol Biol Phys. 2000;47:65–71
  21. Mendenhall WM, Parsons JT, Stringer SP, et al.  Stage T3 squamous cell carcinoma of the glottic larynx. A comparison of laryngectomy and irradiation. Int J Radiat Oncol Biol Phys. 1992;23:725–732
  22. Mendenhall WM. T3–4 squamous cell carcinoma of the larynx treated with radiation therapy alone. Semin Radiat Oncol. 1998;8:262–269
  23. Parsons JT, Mendenhall WM, Stringer SP, et al.  T4 laryngeal carcinoma. radiotherapy alone with surgery reserved for salvage. Int J Radiat Oncol Biol Phys. 1998;40:549–552
  24. Mendenhall WM, Parsons JT, Stringer SP, et al.  Carcinoma of the supraglottic larynx (A basis for comparing results of radiotherapy and surgery). Head Neck. 1990;12:204–209
  25. Van den Bogaert W, Ostyn F, van der Schueren E. The primary treatment of advanced vocal cord cancer (Laryngectomy or radiotherapy?). Int J Radiat Oncol Biol Phys. 1983;9:324–329
  26. Fu KK, Pajak TF, Trotti A, et al.  A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation, and two variants of accelerated fractionation to standard fractionation radiotherapy for head, and neck squamous cell carcinoma; first report of RTOG 9003. Int J Radiat Oncol Biol Phys. 2000;48:7–16
  27. The Department of Veterans Affairs Laryngeal Cancer Study Group . Induction chemotherapy plus radiation therapy compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med. 1991;324:1685–1690
  28. Pignon JP, Bourhis J, Domenge C, et al.  MACH-NC Collaborative Group   Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma (Three meta-analysis of updated individual data. Meta-Analysis of Chemotherapy on Head and Neck Cancer). Lancet. 2000;355:949–955
  29. Forastiere AA. Larynx preservation trials (a critical appraisal). Semin Radiat Oncol. 1998;8:254–261
  30. Cooper JS, Farnan NC, Asbell SO, et al.  Radiation Therapy Oncology Group   Recursive partitioning analysis of 2105 patients treated in the studies of head and neck cancer. Cancer. 1996;77:1905–1911
  31. Cooper JS, Pajak TF, Forastiere AA, et al.  Precisely defining high-risk operable head and neck tumors based on RTOG 85-03 and 88-24 (Targets for post-operative radiochemotherapy?). Head Neck. 1998;20:588–594
  32. Myers EN, Alvi A. Management of carcinoma of the supraglottic larynx (Evolution, current concepts, and future trends). Laryngoscope. 1996;106:559–567
  33. Lee WR, Berkey B, Marcial V, et al.  Anemia is associated with decreased survival and increased locoregional failure in patients with locally advanced head and neck carcinoma; a secondary analysis of RTOG 8527. Int J Radiat Oncol Biol Phys. 1998;42:1069–1075
  34. Warde P, O’Sullivan B, Bristow RG, et al.  T1/T2 glottic cancer managed by external beam radiotherapy. The influence of pretreatment hemoglobin on local control. Int J Radiat Oncol Biol Phys. 1998;41:347–353
  35. Frommhold H, Guttenberger R, Henke M. The impact of blood hemoglobin content on the outcome of radiotherapy. The Freiburg experience. Strahlenther Onkol. 1998;174(Suppl. 4):31–34
  36. Van Acht MJ, Hermans J, Boks , et al.  The prognostic value of hemoglobin and a decrease in hemoglobin during radiotherapy in laryngeal carcinoma. Radiother Oncol. 1992;23:229–235
  37. Quilty PM, Duncan W. The influence of hemoglobin level on the regression and long term local control of transitional cell carcinoma of the bladder following photon irradiation. Int J Radiat Oncol Biol Phys. 1986;12:1735–1742
  38. Tarnawski R, Skladowski K, Maciejewski B. Prognostic value of hemoglobin concentration in radiotherapy for cancer of supraglottic larynx. Int J Radiat Oncol Biol Phys. 1997;38:1007–1011
  39. Henke M, Guttenberger R, Barke A, et al.  Erythropoietin for patients undergoing radiotherapy (A pilot study). Radiother Oncol. 1999;50:185–190
  40. Karp D, Vaughan C, Carter R, et al.  Larynx preservation using induction chemotherapy in advanced but resectable head and neck cancer. J Clin Oncol. 1991;9:850–859
  41. Shirinian M, Weber R, Lippman S, et al.  Larynx preservation by induction chemotherapy plus radiotherapy in locally advanced head and neck cancer (The M.D. Anderson Cancer Center experience). Head Neck. 1994;16:39–44
  42. Richar JM, Sancho-Garnier H, Pessey JJ, et al.  Randomized trial of induction chemotherapy in larynx carcinoma. Oral Oncol. 1998;34:224–228
  43. Hillman RE, Walsh MJ, Wolf GT, et al.  Functional outcomes following treatment of advanced laryngeal cancer. Part I- Voice preservation in advanced laryngeal cancer. Part II- Laryngectomy and rehabilitation (The state of the art in the VA System). Ann Otol Rhinol Laryngol. 1998;172(Suppl.):1–27
  44. Fisher SG, Gao X, Mohideen N, et al.  Impact of radiotherapy on second primary cancer risk in patients treated for laryngeal cancer (A population based study). (Abstr.) Int J Radiat Oncol Biol Phys. 2000;48(Suppl. 3):266
  45. Mancuso AA, Mukherji SK, Schmalfuss I, et al.  Preradiotherapy computed tomography as a predictor of local control in supraglottic carcinoma. J Clin Oncol. 1999;17:631–637
  46. Hermans R, Van den Bogaert W, Rjinders A, et al.  Value of computed tomography as outcome predictor of supraglottic squamous cell carcinoma treated by definitive radiation therapy. Int J Radiat Oncol Biol Phys. 1999;44:755–765

PII: S0360-3016(01)01538-3

International Journal of Radiation Oncology * Biology * Physics
Volume 50, Issue 5 , Pages 1172-1180 , 1 August 2001

Article Tools

* Image Usage & Resolution