International Journal of Radiation Oncology * Biology * Physics
Volume 50, Issue 5 , Pages 1154-1160 , 1 August 2001

Surgery and postoperative radiation therapy in FIGO Stage IIIC endometrial carcinoma

Presented at the 42nd Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), Boston, MA, October 22–26, 2000.

  • Arno J Mundt, M.D.

      Affiliations

    • Department of Radiation and Cellular Oncology, Section of Gynecologic Oncology, University of Chicago Hospitals, Chicago, IL, USA
    • Corresponding Author InformationReprint requests to: Dr. Arno J. Mundt, Department of Radiation and Cellular Oncology, University of Chicago Hospitals, MC 9006, 5758 S. Maryland Ave, Chicago, IL 60637
    • ,
  • Kevin T Murphy, M.D.

      Affiliations

    • Department of Radiation and Cellular Oncology, Section of Gynecologic Oncology, University of Chicago Hospitals, Chicago, IL, USA
    • ,
  • Jacob Rotmensch, M.D.

      Affiliations

    • Department of Radiation and Cellular Oncology, Section of Gynecologic Oncology, University of Chicago Hospitals, Chicago, IL, USA
    • Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago Hospitals, Chicago, IL, USA
    • ,
  • Steven E Waggoner, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago Hospitals, Chicago, IL, USA
    • ,
  • S.Diane Yamada, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago Hospitals, Chicago, IL, USA
    • ,
  • Philip P Connell, M.D.

      Affiliations

    • Department of Radiation and Cellular Oncology, Section of Gynecologic Oncology, University of Chicago Hospitals, Chicago, IL, USA

Received 21 November 2000 ,Revised 15 March 2001 ,Accepted 21 March 2001.

References 

  1. Landis SH, Murray T, Bolden S, et al.  Cancer statistics 1998. CA Cancer J Clin. 1998;48:6–29
  2. Algan O, Tabesh T, Hanlon A, et al.  Improved outcome in patients treated with postoperative radiation therapy for pathologic Stage I/II endometrial cancer. Int J Radiat Oncol Biol Phys. 1998;35:925–933
  3. Morrow CP, Bundy BN, Kurman RJ, et al.  Relationship between surgical-pathological risk factors and outcome in clinical stage I and II carcinoma of the endometrium (A Gynecol Oncol Group study). Gynecol Oncol. 1991;40:55–65
  4. Piver MS, Lele SB, Barlow JJ, et al.  Paraortic lymph node evaluation in stage I endometrial cancer. Obstet Gynecol. 1982;59:97–100
  5. Hicks ML, Piver MS, Puretz JL, et al.  Survival in patients with paraortic lymph node metastases from endometrial adenocarcinoma clinically confined to the uterus. Int J Radiat Oncol Biol Phys. 1993;26:607–611
  6. International Federation of Gynecology, and Obstetrics . Annual report of the results of treatment in gynecological cancer. Int J Gyneacol Obstet. 1988;20:75–77
  7. Greven KM, Lanciano RM, Corn B, et al.  Pathologic stage III endometrial carcinoma. Prognostic factors and patterns of recurrence. Cancer. 1993;71:3697–3702
  8. Gibbons S, Martinez A, Schray M, et al.  Adjuvant whole abdominopelvic irradiation for high risk endometrial carcinoma. Int J Radiat Oncol Biol Phys. 1991;21:1019–1025
  9. Greer BE, Hamberger AD. Treatment of intraperitoneal metastatic adenocarcinoma of the endometrium by the whole-abdomen moving-strip technique and pelvic boost irradiation. Gynecol Oncol. 1983;16:365–373
  10. Martinez A, Schray M, Podratz , et al.  Postoperative whole abdomino-pelvic irradiation for patients with high risk endometrial cancer. Int J Radiat Oncol Biol Phys. 1989;17:371–377
  11. Potish RA, Twiggs LB, Adcock LL, et al.  Role of whole abdominal radiation therapy in the management of endometrial cancer (Prognostic importance of factors indicating peritoneal metastases). Gynecol Oncol. 1985;21:80–86
  12. Randall ME, Spirtos NM, Dvoretsky P. Whole abdominal radiotherapy versus combination chemotherapy with doxorubicin and cisplatin in advanced endometrial carcinoma (phase III) (Gynecol Oncol Group Study No. 122). Monogr Natl Cancer Inst. 1995;19:13–15
  13. Nelson G, Randall M, Sutton G, et al.  FIGO stage IIIC endometrial carcinoma with metastases confined to pelvic lymph nodes (Analysis of treatment outcomes, prognostic variables and failure patterns following adjuvant radiation therapy). Gynecol Oncol. 1999;75:211–214
  14. Greven KM, Curran WJ, Whittington R, et al.  Analysis of failure patterns in Stage III endometrial carcinoma and therapeutic implications. Int J Radiat Oncol Biol Phys. 1989;17:35–39
  15. Schorge JO, Molpus KL, Goodman A, et al.  The effect of postsurgical therapy on stage III endometrial carcinoma. Gynecol Oncol. 1996;63:34–39
  16. Komaki R, Matingly RF, Raymond GH, et al.  Irradiation of para-aortic lymph node metastases from carcinoma of the cervix or endometrium. Radiology. 1983;147:245–248
  17. Corn BW, Lanciano RM, Greven KM, et al.  Endometrial cancer with para-aortic adenopathy (Patterns of failure and opportunities for cure). Int J Radiat Oncol Biol Phys. 1992;24:223–227
  18. Rose PG, Cha SD, Tak WK, et al.  Radiation therapy for surgically proven para-aortic node metastasis in endometrial carcinoma. Int J Radiat Oncol Biol Phys. 1992;24:229–233
  19. Feuer GA, Calanog A. Endometrial carcinoma (Treatment of positive paraaortic nodes). Gynecol Oncol. 1987;27:10–109
  20. Blythe JG, Hodel KA, Wahl TP, et al.  Para-aortic node biopsy in cervical and endometrial cancers (Does it affect survival?). Am J Obstet Gynecol. 1986;155:306–314
  21. Potish RA, Twiggs LB, Adcock LL, et al.  Paraaortic lymph node radiotherapy in cancer of the uterine corpus. Obstet Gynecol. 1985;65:251–254
  22. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481
  23. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep. 1966;50:163–170
  24. Hirahatake K, Hareyama H, Sakuragi N, et al.  A clinical and pathologic study on para-aortic lymph node metastasis in endometrial carcinoma. J Surg Oncol. 1997;65:82–87
  25. Girardi F, Petru E, Heydarfadai M, et al.  Pelvic lymphadenectomy in the surgical treatment of endometrial cancer. Gynecol Oncol. 1993;49:177–180
  26. Weiss MF, Connell PP, Waggoner S, et al.  External pelvic radiation therapy in stage IC endometrial carcinoma. Obstet Gynecol. 1999;93:599–602
  27. Calvin DP, Connell PP, Rotmensch J, et al.  Surgery and postoperative radiation therapy in stage II endometrial carcinoma. Am J Clin Oncol. 1999;22:338–343
  28. Stock RG, Chen ASJ, Karasek K. Patterns of spread in node-positive cervical cancer (The relationship between local control and distant metastases). Cancer J Sci Am. 1996;2:256–259
  29. Corn BW, Lanciano RM, Greven KM, et al.  Impact of improved irradiation technique, age, and lymph node sampling on the severe complication rate of surgically staged endometrial cancer patients (A multivariate analysis). J Clin Oncol. 1994;12:510–515
  30. Roeske JC, Mundt AJ, Halpern H, et al.  Late rectal sequelae following definitive radiation therapy for carcinoma of the uterine cervix (A dosimetric analysis). Int J Radiat Oncol Biol Phys. 1997;37:351–358
  31. Roeske JC, Lujan A, Rotmensch J, et al.  Intensity modulated whole pelvic radiation therapy in patients with gynecological malignancies. Int J Radiat Oncol Biol Phys. 2000;48:1613–1621
  32. Mundt AJ, Roeske JC, Lujan A, et al.Initial clinical experience with intensity modulated whole pelvic radiation therapy in women with gynecologic malignancies. Gynecol Oncol In press.
  33. Portelance L, Chao C, Grigsby PW, et al.  Intensity modulated radiation therapy (IMRT) may reduce small bowel, rectum and bladder complications in patients with cervical cancer treated to the pelvis and paraortics area. (Abstr.) Int J Radiat Oncol Biol Phys. 1999;45(Suppl. 1):211
  34. Morrow CP, Bundy BN, Homesley HD, et al.  Doxorubicin as an adjuvant following surgery and radiation therapy in patients with high risk endometrial carcinoma, stage I and occult stage II (A Gynecol Oncol Group study). Gynecol Oncol. 1990;36:166–171
  35. Lewis GC, Slack NH, Mortel R, et al.  Adjuvant progestogen therapy in the primary definitive treatment of endometrial cancer. Gynecol Oncol. 1974;2:368–375
  36. Macdonald RR, Thorogood J, Mason MK, et al.  A randomized trial of progestogens in the primary treatment of endometrial carcinoma. Br J Obstet Gynecol. 1988;95:166–173
  37. Corn BW, Lanciano RM, D’Agostino R, et al.  The relationship of local and distant failure from endometrial cancer (Defining a clinical paradigm). Gynecol Oncol. 1997;66:411–416

PII: S0360-3016(01)01590-5

International Journal of Radiation Oncology * Biology * Physics
Volume 50, Issue 5 , Pages 1154-1160 , 1 August 2001

Article Tools

* Image Usage & Resolution