International Journal of Radiation Oncology * Biology * Physics
Volume 51, Issue 3 , Pages 599-604 , 1 November 2001

Hypothyroidism incidence after multimodality treatment for stage III and IV squamous cell carcinomas of the head and neck

  • A.Dimitrios Colevas, M.D.

      Affiliations

    • Head and Neck Oncology Program, Dana-Farber Cancer Institute, Boston MA, USA
    • Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
    • Corresponding Author InformationReprint requests to: A. Dimitrios Colevas, M.D., Investigational Drug Branch, Cancer Therapy Evaluation Program, DCTD, National Cancer Institute, Executive Plaza North, Room 7131, 6130 Executive Blvd., Rockville, MD 20852-7426. Tel: 301 435-9128; Fax: 301 402 0428
    • ,
  • Richard Read, B.A.

      Affiliations

    • Head and Neck Oncology Program, Dana-Farber Cancer Institute, Boston MA, USA
    • ,
  • John Thornhill, B.A.

      Affiliations

    • Head and Neck Oncology Program, Dana-Farber Cancer Institute, Boston MA, USA
    • ,
  • Sudeshna Adak, Ph.D.

      Affiliations

    • Department of Biostatistical Science, Dana-Farber Cancer Institute, Boston, MA, USA
    • ,
  • Roy Tishler, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    • ,
  • Paul Busse, M.D.

      Affiliations

    • Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    • ,
  • Yi Li, Ph.D.

      Affiliations

    • Department of Biostatistical Science, Dana-Farber Cancer Institute, Boston, MA, USA
    • ,
  • Marshall Posner, M.D.

      Affiliations

    • Head and Neck Oncology Program, Dana-Farber Cancer Institute, Boston MA, USA
    • Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Received 18 December 2000 ,Revised 13 April 2001 ,Accepted 19 May 2001.

References 

  1. Clemente C. Anatomy (A regional atlas of the human body). 2nd ed.. Baltimore: Urban and Schwartzenberg; 1981;
  2. Hancock S, Cox R, McDougal I. Thyroid disease after treatment of Hodgkin’s disease. N Engl J Med. 1991;325:599–605
  3. Kuten A, Lubochitski R, Fishman G, et al.  Postradiotherapy hypothyroidism (Radiation dose response and chemotherapeutic radiosensitization at less than 40 Gy). J Surg Oncol. 1996;61:281–283
  4. Hancock S, McDougal I, Constine L. Thyroid abnormalities after therapeutic external radiation. Int J Radiat Oncol Biol Phys. 1995;31:1165–1170
  5. Sinard R, Tobin E, Mazzaferri E, et al.  Hypothyroidism after treatment for nonthyroid head and neck cancer. Arch Otolaryngol Head Neck Surg. 2000;126:652–657
  6. Posner M, Ervin T, Miller D, et al.  The incidence of hypothyroidism following multimodality treatment for advanced squamous cell cancer of the head and neck. Laryngoscope. 1984;94:451–454
  7. Tamura K, Shimaoka K, Friedman M. Thyroid abnormalities associated with treatment of malignant lymphoma. Cancer. 1981;47:2704–2711
  8. Tami T, Gomez P, Parker G, et al.  Thyroid dysfunction after radiation therapy in head and neck cancer patients. Am J Otolaryngol. 1992;13:357–362
  9. Ogilvy-Stuart A, Shalet S, Gattamameni H. Thyroid function after treatment of brain tumors in children. J Pediatr. 1991;119:733–737
  10. Grande C. Hypothyroidism following radiotherapy for head and neck cancer (Multivariate analysis of risk factors). Radiother Oncol. 1992;25:31–36
  11. Norris C, Posner M, Tishler R, et al.  A phase I study of outpatient docetaxel (Taxotere), cisplatin, 5-FU, and leucovorin (OP-TPFL) as induction chemotherapy for patients with squamous cell carcinoma of the head, and neck (SCCHN). Proc Am Soc Clin Oncol. 1999;18:397a
  12. Colevas A, Busse P, Norris C, et al.  Induction chemotherapy with docetaxel, cisplatin, 5-fluorouracil, and leucovorin (TPFL5) for squamous cell carcinoma of the head and neck (A phase I/II trial). J Clin Oncol. 1998;16:1331–1339
  13. Colevas A, Norris C, Tishler R, et al.  A phase II trial of TPFL (docetaxel, cisplatin, 5-fluorouracil, leucovorin) as induction for squamous cell carcinoma of the head, and neck (SCCHN). J Clin Oncol. 1999;17:3503–3511
  14. Clark J, Busse P, Norris C, et al.  Induction chemotherapy with cisplatin, fluorouracil, and high-dose leucovorin for squamous cell carcinoma of the head and neck (Long-term results). J Clin Oncol. 1997;15:3100–3110
  15. Kaplan E, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481
  16. Utiger R. Hypothyroidism. In:  DeGroot L editors. Endocrinology. 2nd ed.. Philadelphia: WB Saunders; 1989;p. 702–713
  17. Posner M, Glisson B, Frenette G, et al.  A multi-center phase I-II trial of docetaxel, cisplatinum, and 5-fluorouracil (TPF) induction chemotherapy for patients with locally advanced squamous cell cancer of the head and neck (SCCHN). J Clin Oncol. 2001;19(4):1096–1104

PII: S0360-3016(01)01688-1

doi: 10.1016/S0360-3016(01)01688-1

International Journal of Radiation Oncology * Biology * Physics
Volume 51, Issue 3 , Pages 599-604 , 1 November 2001

Article Tools

* Image Usage & Resolution