International Journal of Radiation Oncology * Biology * Physics
Volume 51, Issue 3 , Pages 571-578 , 1 November 2001

Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer

  • K.Kian Ang, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • Corresponding Author InformationReprint requests to: K. Kian Ang, M.D., Department of Radiation Oncology, M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 97, Houston, TX 77030. Tel: 713-792-3400; Fax: 713-794-5573
    • ,
  • Andy Trotti, M.D.

      Affiliations

    • Division of Radiation Oncology, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA
    • ,
  • Barry W Brown, Ph.D.

      Affiliations

    • Department of Biomathematics, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Adam S Garden, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Robert L Foote, M.D.

      Affiliations

    • Department of Radiation Oncology, Mayo Clinic, Mayo Medical School, Rochester, MN, USA
    • ,
  • William H Morrison, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Fady B Geara, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • Dr. Geara is currently at the Department of Radiation Oncology, American University of Beirut, New York; Dr. Peters is currently at the Division of Radiation Oncology, Peter MacCallum Cancer Institute, East Melbourne, Australia.
    • ,
  • Douglas W Klotch, M.D.

      Affiliations

    • Department of Otolaryngology/Head and Neck Surgery, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA
    • ,
  • Helmuth Goepfert, M.D.

      Affiliations

    • Department of Head and Neck Surgery, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Lester J Peters, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

Received 7 February 2001 ,Revised 17 May 2001 ,Accepted 19 May 2001.

References 

  1. Withers HR, Taylor JMG, Maciejewski B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol. 1988;27:131–146
  2. Ang K. Altered fractionation in head and neck cancer. Semin Radiat Oncol. 1998;8:230–236
  3. Vikram B, Strong EW, Shah JP, et al.  Failure in the neck following multimodality treatment for advanced head and neck cancer. Head Neck Surg. 1984;6:724–729
  4. Byers RM, Clayman GL, Guillamondegui OM, et al.  Resection of advanced cervical metastasis prior to definitive radiotherapy for primary squamous carcinomas of the upper aerodigestive tract. Head Neck. 1992;14:133–138
  5. Garden AS, Weber RS, Ang KK, et al.  Postoperative radiation therapy for malignant tumors of minor salivary glands. Cancer. 1994;73:2563–2569
  6. Peters LJ, Goepfert H, Ang KK, et al.  Evaluation of the dose for postoperative radiation therapy of head and neck cancer (first report of a prospective randomized trial). Int J Radiat Oncol Biol Phys. 1993;26:3–11
  7. Looser KG, Shah JP, Strong EN. The significance of positive margins in marginally resected epidermoid carcinoma. Head Neck Surg. 1978;1:107–111
  8. Mantravadi RVP, Haas RE, Liebner EJ, et al.  Postoperative radiotherapy for persistent tumor at the surgical margin in head and neck cancers. Laryngoscope. 1983;93:1337–1340
  9. Mirimanoff RO, Wang CC, Doppke KP. Combined surgery and postoperative radiation therapy for advanced laryngeal and hypopharyngeal carcinomas. Int J Radiat Oncol Biol Phys. 1985;11:499–504
  10. Carter RL, Tanner NSB, Clifford P, et al.  Perineural spread in squamous cell carcinomas of the head and neck (A clinicopathological study). Clin Otolaryngol. 1979;4:271–281
  11. Shah JP, Cendon RA, Farr HW, et al.  Carcinoma of the oral cavity. Am J Surg. 1976;132:504–507
  12. Olsen KD, Caruso M, Foote RL, et al.  Primary head and neck cancer (Histopathologic predictors of recurrence after neck dissection in patients with lymph node involvement). Arch Otolaryngol Head Neck Surg. 1994;120:1370–1374
  13. Johnson JT, Barnes EL, Myers EN, et al.  The extracapsular spread of tumors in cervical node metastasis. Arch Otolaryngol. 1981;107:725–729
  14. Ang KK, Peters LJ. Altered fractionation in radiation oncology. In:  DeVita VTJ,  Hellman S,  Rosenberg SA editor. Cancer (Principles and practice of oncology). Philadelphia: JB Lippincott; 1994;p. 1–15
  15. Farr HW, Arthur K. Epidermoid carcinoma of the mouth and pharynx. J Laryngol Otolaryngol. 1972;86:243–253
  16. Fu KK, Pajak TF, Trotti A, et al.  A radiation therapy oncology group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas (First report of RTOG 9003). Int J Radiat Oncol Biol Phys. 2000;48:7–16
  17. Peters LJ, Withers HR. Applying radiobiological principles to combined modality treatment of head and neck cancer—The time factor. Intl J Radiat Oncol Biol Phys. 1997;39:831–836
  18. Trotti A, Klotch D, Endicott J, et al.  Postoperative accelerated radiotherapy in high-risk squamous cell carcinoma of the head and neck (Long-term results of a prospective trial). Head Neck. 1998;20:119–123
  19. Ang KK, Peters LJ, Thames HD. Altered fractionation schedules. In:  Perez CA,  Brady LW,  Perez CA, et al. editor. Principles and practices of radiation oncology. Philadelphia: Lippincott-Raven; 1997;p. 300–320

☆ Supported by Grants CA-06294 and CA-16672 from the National Cancer Institute, Gilbert H. Fletcher Chair, and Texas Tobacco Settlement Funds.

PII: S0360-3016(01)01690-X

doi: 10.1016/S0360-3016(01)01690-X

International Journal of Radiation Oncology * Biology * Physics
Volume 51, Issue 3 , Pages 571-578 , 1 November 2001

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