International Journal of Radiation Oncology * Biology * Physics
Volume 53, Issue 2 , Pages 334-343 , 1 June 2002

Concomitant chemoirradiation for stage III–IV nasopharyngeal carcinoma in Chinese patients: results of a matched cohort analysis

  • Daniel T.T Chua (F.R.C.R.)

      Affiliations

    • Corresponding Author InformationReprint requests to: Daniel T. T. Chua, F.R.C.R., Department of Clinical Oncology, PB-115, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China. Tel: 852-28-55-4223; Fax: 852-28-72-6426
    • Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
  • ,
  • Jonathan S.T Sham (F.R.C.R.)

      Affiliations

    • Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
  • ,
  • Gordon K.H Au (F.R.C.R.)

      Affiliations

    • Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
  • ,
  • Damon Choy (F.R.C.R.)

      Affiliations

    • Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China

Received 11 September 2001 ,Revised 2 January 2002 ,Accepted 7 January 2002.

References 

  1. International Nasopharynx Cancer Study Group . VUMCA I Trial (Preliminary results of a randomized trial comparing neoadjuvant chemotherapy (cisplatin, epirubicin, bleomycin) plus radiotherapy vs. radiotherapy alone in stage IV (≥N2, M0) undifferentiated nasopharyngeal carcinoma—A positive effect on progression-free survival). Int J Radiat Oncol Biol Phys. 1996;35:463–469
  2. Chua DTT, Sham JST, Choy D, et al.  Preliminary report of the Asian-Oceanian Clinical Oncology Association randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with locoregionally advanced nasopharyngeal carcinoma. Cancer. 1998;83:2270–2283
  3. Chua DTT, Sham JST, Choy D, et al.  Patterns of failure after induction chemotherapy and radiotherapy for locoregionally advanced nasopharyngeal carcinoma (The Queen Mary Hospital experience). Int J Radiat Oncol Biol Phys. 2001;49:1219–1228
  4. Ma J, Mai H, Hong M, et al.  Results of a prospective randomized trial comparing neoadjuvant chemotherapy plus radiotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma. J Clin Oncol. 2001;19:1350–1357
  5. Rossi A, Molinari R, Boracchi P, et al.  Adjuvant chemotherapy with vincristine, cyclophosphamide, and doxorubicin after radiotherapy in local-regional nasopharyngeal cancer (Results of a 4-year multicenter randomized study). J Clin Oncol. 1998;6:1401–1410
  6. Chan ATC, Teo PML, Leung TWT, et al.  A prospective randomized study of chemotherapy adjunctive to definitive radiotherapy in advanced nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 1995;33:569–577
  7. Al-Sarraf M, LeBlanc M, Shanker Giri PG, et al.  Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer (Phase III randomized intergroup study 0099). J Clin Oncol. 1998;16:1310–1317
  8. American Joint Committee on Cancer . Manual for staging of cancer. 5th ed. Philadelphia: JB Lippincott; 1997;
  9. Ho JHC. Nasopharynx. In:  Halnan KE editors. Treatment of cancer. London: Chapman and Hall; 1982;p. 249–267
  10. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481
  11. Cooper JS, Lee H, Torrey M, et al.  Improved outcome secondary to concurrent chemoradiotherapy for advanced carcinoma of the nasopharynx (Preliminary corroboration of the Intergroup experience). Int J Radiat Oncol Biol Phys. 2000;47:861–866
  12. Tan EH, Chua ET, Wee J, et al.  Concurrent chemoradiotherapy followed by adjuvant chemotherapy in Asian patients with nasopharyngeal carcinoma (Toxicities and preliminary results). Int J Radiat Oncol Biol Phys. 1999;45:597–601
  13. Cheng SH, Jian JJ, Tsai SYC, et al.  Long-term survival of nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy. Int J Radiat Oncol Biol Phys. 2000;48:1323–1330
  14. Chan ATC, Teo PML, Ngan RKC, et al.  A phase III randomized trial comparing concurrent chemotherapy-radiotherapy with radiotherapy alone in loco-regionally advanced nasopharyngeal carcinoma. Abstract Proc Am Soc Clin Oncol. 2000;19:1637

 Supported by grants from The University of Hong Kong (CRCG Grant No. 337/037/0001, 335/037/0001-2, and 10202650/25134/21600/323/01).

PII: S0360-3016(02)02710-4

International Journal of Radiation Oncology * Biology * Physics
Volume 53, Issue 2 , Pages 334-343 , 1 June 2002