International Journal of Radiation Oncology * Biology * Physics
Volume 53, Issue 3 , Pages 543-547 , 1 July 2002

Hypothyroidism in children with medulloblastoma: a comparison of 3600 and 2340 cGy craniospinal radiotherapy

  • Arnold C Paulino, M.D.

      Affiliations

    • Corresponding Author InformationReprint requests to: Arnold C. Paulino, M.D., Department of Radiation Oncology, Emory Clinic, 1365 Clifton Road NE, Room A1300, Atlanta, GA 30322 USA. Tel: (404) 778-4126; Fax: (404) 778-4139
    • Department of Radiation Oncology, The University of Iowa College of Medicine, University of Iowa Health Care and Children’s Hospital of Iowa, Iowa City, IA, USA
    • Department of Pediatrics, The University of Iowa College of Medicine, University of Iowa Health Care and Children’s Hospital of Iowa, Iowa City, IA, USA

Received 18 September 2001 ,Accepted 14 January 2002.

References 

  1. Constine LS, Donaldson SS, McDougall IR, et al.  Thyroid dysfunction after radiotherapy in children with Hodgkin’s disease. Cancer. 1984;53:878–883
  2. Blatt J, Lee P, Suttnes J, et al.  Pulsatile growth hormone secretion in children with acute lymphoblastic leukemia after 1800 cGy cranial irradiation. Int J Radiat Oncol Biol Phys. 1988;15:1001–1006
  3. Rose SR, Lustig RH, Pitukcheewanont P, et al.  Diagnosis of hidden central hypothyroidism in survivors of childhood cancer. J Clin Endocrinol Metab. 1999;84:4472–4479
  4. Oberfield SE, Allen JC, Pollack J, et al.  Long-term endocrine sequelae after treatment of medulloblastoma (Prospective study of growth and thyroid function). J Pediatr. 1986;108:219–223
  5. Chin D, Sklar C, Donahue B, et al.  Thyroid dysfunction as a late effect in survivors of pediatric medulloblastoma/primitive neuroectodermal tumors (A comparison of hyperfractionated versus conventional radiotherapy). Cancer. 1997;80:798–804
  6. Livesey EA, Brook CGD. Thyroid dysfunction after radiotherapy and chemotherapy of brain tumors. Arch Dis Child. 1989;64:593–595
  7. Packer RJ, Goldwein J, Nicholson HS, et al.  Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy (A Children’s Cancer Group Study). J Clin Oncol. 1999;17:2127–2136
  8. Mulhern RK, Kepner JL, Thomas PR, et al.  Neuropsychologic functioning of survivors of childhood medulloblastoma randomized to receive conventional or reduced-dose craniospinal irradiation (A Pediatric Oncology Group Study). J Clin Oncol. 1998;16:1723–1728
  9. Paulino AC. Radiotherapeutic management of medulloblastoma. Oncology. 1997;11:813–823
  10. Narayana A, Jeswani S, Paulino AC. The cranial-spinal junction in medulloblastoma (Does it matter?). Int J Radiat Oncol Biol Phys. 1999;44:81–84
  11. Tarbell NJ, Smith AR, Adams J, et al.  The challenge of conformal radiotherapy in the curative treatment of medulloblastoma. Int J Radiat Oncol Biol Phys. 2000;46:265–266
  12. Duffner PH, Cohen ME, Anderson SW, et al.  Long-term effects of treatment on endocrine function in children with brain tumors. Ann Neurol. 1983;14:528–532
  13. Ogilvy-Stuart AL, Shalet SM, Gottamaneni HR. Thyroid function after treatment of brain tumors in children. J Pediatr. 1991;119:733–737
  14. Constine LS, Woolf PD, Cann D, et al.  Hypothalamic-pituitary dysfunction after radiation for brain tumors. N Engl J Med. 1993;328:87–94
  15. Hancock S, Cox R, McDougall I. Thyroid diseases after treatment for Hodgkin’s disease. N Engl J Med. 1991;325:599–605
  16. Sutcliffe SB, Chapman R, Wrigley PFM. Cyclical combination chemotherapy and thyroid function in patients with advanced Hodgkin’s disease. Med Pediatr Oncol. 1981;9:439–448

PII: S0360-3016(02)02744-X

International Journal of Radiation Oncology * Biology * Physics
Volume 53, Issue 3 , Pages 543-547 , 1 July 2002

Article Tools

* Image Usage & Resolution