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International Journal of Radiation Oncology * Biology * Physics
Volume 53, Issue 4
, Pages 854-861
, 15 July 2002
Expression of hypoxia-inducible factor-1α in cervical carcinomas: correlation with tumor oxygenation
References
- Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 1996;56:4509–4515
- Oxygenation predicts radiation response and survival in patients with cervix cancer. [published erratum appears in Radiother Oncol 1999;50:371] Radiother Oncol. 1998;48:149–156
- Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res. 1996;56:941–943
- Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 1997;38:285–289
- . Microenvironment-induced cancer metastasis. [In Process Citation] Int J Radiat Biol. 2000;76:589–605
- . The molecular response of mammalian cells to hypoxia and the potential for exploitation in cancer therapy. Br J Cancer Suppl. 1996;27:S126–S132
- Tumor hypoxia and heterogeneity (Challenges and opportunities for the future). Semin Radiat Oncol. 1996;6:59–70
- . The molecular basis of the hypoxia response pathway (Tumor hypoxia as a therapy target). Cancer Metastasis Rev. 1998;17:187–194
- . Purification and characterization of hypoxia-inducible factor 1. J Biol Chem. 1995;270:1230–1237
- . Mammalian oxygen sensing, signaling and gene regulation. J Exp Biol. 2000;203:1253–1263
- Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. Am J Physiol. 1996;271:C1172–C1180
-
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway.
Proc Natl Acad Sci USA. 1998;95:7987–7992
- Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway. J Biol Chem. 1999;274:6519–6525
- Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem. 1996;271:32529–32537
- . A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol. 1992;12:5447–5454
- Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996;16:4604–4613
- Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes (Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia). J Biol Chem. 1997;272:23659–23667
- Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res. 1999;59:3915–3918
- Detection of hypoxia in human squamous cell carcinoma by EF5 binding. Cancer Res. 2000;60:2018–2024
- Pimonidazole (A novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma). Gynecol Oncol. 1998;71:270–277
- Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas. [In Process Citation] Br J Cancer. 2000;83:674–683
- The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol. 2000;157:411–421
- . Proportional hazards tests and diagnostics based on weighted residuals. Biometrika. 1994;81:515–526
- Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol. 1993;26:45–50
- . Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol. 1996;41:31–39
- Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 1999;59:5830–5835
- Expression of hypoxia-inducible factor 1alpha in brain tumors (Association with angiogenesis, invasion, and progression). Cancer. 2000;88:2606–2618
- Hypoxia-inducible factor-1α is an intrinsic marker for hypoxia in cervical cancer xenografts. Cancer Res. 2001;61:7394–7398
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Proc Natl Acad Sci USA. 1995;92:5510–5514
- Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem. 1996;271:32253–32259
- Spatial relationship between hypoxia and the (perfused) vascular network in a human glioma xenograft (A quantitative multi-parameter analysis). (1) Int J Radiat Oncol Biol Phys. 2000;48:571–582
- Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res. 2000;60:4693–4696
- Hypoxia marker labeling in tumor biopsies (Quantification of labeling variation and criteria for biopsy sectioning). Radiother Oncol. 1997;44:171–176
☆ Supported by the National Cancer Institute of Canada, using funds raised by the Terry Fox run.
PII: S0360-3016(02)02815-8
© 2002 Elsevier Science Inc. All rights reserved.
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International Journal of Radiation Oncology * Biology * Physics
Volume 53, Issue 4
, Pages 854-861
, 15 July 2002
