International Journal of Radiation Oncology * Biology * Physics
Volume 53, Issue 4 , Pages 880-888 , 15 July 2002

Pathologic tumor size and lymph node status predict for different rates of locoregional recurrence after mastectomy for breast cancer patients treated with neoadjuvant versus adjuvant chemotherapy

Presented at the American Society for Therapeutic Radiology and Oncology 2001 Meeting, San Francisco, CA.

  • Thomas A Buchholz, M.D.

      Affiliations

    • Corresponding Author InformationReprint requests to: Thomas A. Buchholz, M.D., Department of Radiation Oncology, Box 97, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030 USA. Tel: (713) 792-3400; Fax: (713) 794-5573
    • Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Angela Katz, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Eric A Strom, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Marsha D McNeese, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • George H Perkins, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Gabriel N Hortobagyi, M.D.

      Affiliations

    • Department of Breast Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Howard D Thames, Ph.D.

      Affiliations

    • Department of Biomathematics, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Henry M Kuerer, M.D., Ph.D.

      Affiliations

    • Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • S.Eva Singletary, M.D.

      Affiliations

    • Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Aysegul A Sahin, M.D.

      Affiliations

    • Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Kelly K Hunt, M.D.

      Affiliations

    • Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Aman U Buzdar, M.D.

      Affiliations

    • Department of Breast Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Vicente Valero, M.D.

      Affiliations

    • Department of Breast Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Nour Sneige, M.D.

      Affiliations

    • Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Susan L Tucker, Ph.D.

      Affiliations

    • Department of Biomathematics, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

Received 21 November 2001 ,Revised 13 March 2002 ,Accepted 19 March 2002.

References 

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  14. Buchholz TA, Tucker SL, Masullo L, et al.  Predictors of local-regional recurrence after neoadjuvant chemotherapy and mastectomy without radiation. J Clin Oncol. 2002;20:17–23
  15. Lenert JT, Vlastos G, Mirza NQ, et al.  Primary tumor response to induction chemotherapy as a predictor of histological status of axillary nodes in operable breast cancer patients. Ann Surg Oncol. 1999;6:762–767
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  18. Koscielny S, Thames HD. Biased methods for estimating local and distant failure rates in breast cancer and a ‘common-sense’ approach. Cancer. 2001;92:2220–2227
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  20. Ravdin PM, De Laurentiis M, Vendely T, et al.  Prediction of axillary lymph node status in breast cancer patients by use of prognostic indicators. J Natl Cancer Inst. 1994;86:1771–1775

☆ Supported in part by National Cancer Institute Department of Health and Human Services Grant CA16672 and T32CA77050 and a grant from the Stanford and Joan Alexander Foundation, Houston, TX. Dr. Buchholz is supported by Grant BC980154, a USAMRMC Breast Cancer Research Program Career Development Award.

PII: S0360-3016(02)02850-X

International Journal of Radiation Oncology * Biology * Physics
Volume 53, Issue 4 , Pages 880-888 , 15 July 2002

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