International Journal of Radiation Oncology * Biology * Physics
Volume 55, Issue 3 , Pages 594-605 , 1 March 2003

Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases

Presented at the 43rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), November 2001.

  • Jackson Sai-Yiu Wu, M.D. (F.R.C.P.C.)

      Affiliations

    • Corresponding Author InformationReprint requests to: Jackson Sai-Yiu Wu, M.D., F.R.C.P.C., Department of Radiation Oncology, Tom Baker Cancer Centre, 1331-29th St., NW, Calgary, Alberta T2N 4N2 Canada. Tel: (403) 944-2095; Fax: (403) 283-1651
    • Division of Radiation Oncology, Hamilton Regional Cancer Centre, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    • ,
  • Rebecca Wong, M.B.Ch.B., M.Sc. (F.R.C.P.C.)

      Affiliations

    • Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Mary Johnston, B.Sc.

      Affiliations

    • Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    • ,
  • Andrea Bezjak, M.D.C.M., M.Sc. (F.R.C.P.C.)

      Affiliations

    • Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Timothy Whelan, B.M.B.Ch. (F.R.C.P.C.)

      Affiliations

    • Division of Radiation Oncology, Hamilton Regional Cancer Centre, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    • ,
  • on behalf of the Cancer Care Ontario Practice Guidelines Initiative Supportive Care Group

      Affiliations

    • Program in Evidence-Based Care, Cancer Care Ontario, Ontario, Canada

Received 28 March 2002 ,Revised 19 July 2002 ,Accepted 30 July 2002.

References 

  1. Ratanatharathorn V, Powers WE, Moss WT, et al.  Bone metastasis (Review and critical analysis of random allocation trials of local field treatment). Int J Radiat Oncol Biol Phys. 1999;44:1–18
  2. McQuay HJ, Collins SL, Carroll D, et al.  Radiotherapy for the palliation of painful bone metastases (Cochrane Review). In: The Cochrane Library, Issue 1. Oxford: Update Software; 2002;
  3. Kirkbride P, Warde P, Panzarella A, et al.  A randomised trial comparing the efficacy of single fraction radiation therapy plus ondansetron with fractionated radiation therapy in the palliation of skeletal metastases. [Abstract] Int J Radiat Oncol Biol Phys. 2000;48(3 Suppl):185
  4. Bone Pain Trial Working Party . 8 Gy single fraction radiotherapy for the treatment of metastatic skeletal pain (Randomised comparison with a multifraction schedule over 12 months of patient follow-up). Radiother Oncol. 1999;52:111–121
  5. Steenland E, Leer JW, van Houwelingen H, et al.  The effect of a single fraction compared to multiple fractions on painful bone metastases (A global analysis of the Dutch Bone Metastasis Study). Radiother Oncol. 1999;52:101–109
  6. Koswig S, Budach V. Remineralization and pain relief in bone metastases after different radiotherapy fractions (10 times 3 Gy vs. 1 time 8 Gy). A prospective study. [in German] Strahlenther Onkol. 1999;175:500–508
  7. Coia LR, Owen JB, Maher EJ, et al.  Factors affecting treatment patterns of radiation oncologists in the United States in the palliative treatment of cancer. Clin Oncol (R Coll Radiol). 1992;4:6–10
  8. Lievens Y, Van den Bogaert W, Rijnders A, et al.  Palliative radiotherapy practice within Western European countries (Impact of their radiotherapy financing system?). Radiother Oncol. 2000;56:289–295
  9. Lievens Y, Kesteloot K, Rijnders A, et al.  Differences in palliative radiotherapy for bone metastases within Western European countries. Radiother Oncol. 2000;56:297–303
  10. van der Linden YM, Leer JW. Impact of randomized trial-outcome in the treatment of painful bone metastases: Patterns of practice among radiation oncologists. A matter of believers vs. non-believers?. Radiother Oncol. 2000;56:279–281
  11. Roos DE. Continuing reluctance to use single fractions of radiotherapy for metastatic bone pain (An Australian and New Zealand practice survey and literature review). Radiother Oncol. 2000;56:315–322
  12. Chow E, Danjoux C, Wong R, et al.  Palliation of bone metastases (A survey of patterns of practice among Canadian radiation oncologists). Radiother Oncol. 2000;56:305–314
  13. Browman GP, Levine MN, Mohide EA, et al.  The practice guidelines development cycle (A conceptual tool for practice guidelines development and implementation). J Clin Oncol. 1995;13:502–512
  14. Jadad A, Moore RA, Carroll D, et al.  Assessing the quality of reports of randomized clinical trials (Is blinding necessary?). Controlled Clin Trials. 1996;17:1–12
  15. Tong D, Gillick L, Hendrickson FR. The palliation of symptomatic osseous metastases (Final results of the Study by the Radiation Therapy Oncology Group). Cancer. 1982;50:893–899
  16. Gaze MN, Kelly CG, Kerr GR, et al.  Pain relief and quality of life following radiotherapy for bone metastases (A randomised trial of two fractionation schedules). Radiother Oncol. 1997;45:109–116
  17. Price P, Hoskin PJ, Easton D, et al.  Prospective randomised trial of single and multifraction radiotherapy schedules in the treatment of painful bony metastases. Radiother Oncol. 1986;6:247–255
  18. Okawa T, Kita M, Goto M, et al.  Randomized prospective clinical study of small, large and twice-a-day fraction radiotherapy for painful bone metastases. Radiother Oncol. 1988;13:99–104
  19. Madsen EL. Painful bone metastasis (Efficacy of radiotherapy assessed by the patients—A randomized trial comparing 4 Gy × 6 versus 10 Gy × 2). Int J Radiat Oncol Biol Phys. 1983;9:1775–1779
  20. Jeremic B, Shibamoto Y, Acimovic L, et al.  A randomized trial of three single-dose radiation therapy regimens in the treatment of metastatic bone pain. Int J Radiat Oncol Biol Phys. 1998;42:161–167
  21. Hoskin PJ, Price P, Easton D, et al.  A prospective randomised trial of 4 Gy or 8 Gy single doses in the treatment of metastatic bone pain. Radiother Oncol. 1992;23:74–78
  22. Nielsen OS, Bentzen SM, Sandberg E, et al.  Randomized trial of single dose versus fractionated palliative radiotherapy of bone metastases. Radiother Oncol. 1998;47:233–240
  23. Cole DJ. A randomized trial of a single treatment versus conventional fractionation in the palliative radiotherapy of painful bone metastases. Clin Oncol (R Coll Radiol). 1989;1:59–62
  24. Niewald M, Tkocz HJ, Abel U, et al.  Rapid course radiation therapy vs. more standard treatment (A randomized trial for bone metastases). Int J Radiat Oncol Biol Phys. 1996;36:1085–1089
  25. Rasmusson B, Vejborg I, Jensen AB, et al.  Irradiation of bone metastases in breast cancer patients (A randomized study with 1 year follow-up). Radiother Oncol. 1995;34:179–184
  26. Hirokawa Y, Wadasaki K, Kashiwado K, et al.  A multi-institutional prospective randomized study of radiation therapy of bone metastases. [Japanese] Nippon Igaku Hoshasen Gakkai Zasshi. 1988;48:1425–1431
  27. Roos DE, O’Brien PC, Smith JG, et al.  A role for radiotherapy in neuropathic bone pain (Preliminary response rates from a prospective trial (Trans-Tasman Radiation Oncology Group, TROG 9605)). Int J Radiat Oncol Biol Phys. 2000;46:975–981
  28. Kagei K, Suzuki K, Shirato H, et al.  A randomized trial of single and multifraction radiation therapy for bone metastasis (A preliminary report). [Japanese] Gan No Rinsho. 1990;36:2553–2558
  29. Gillick L, Goldberg S. Technical report No. 185R: Final Analysis RTOG Protocol No. 74–02. 1981;
  30. Blitzer PH. Reanalysis of the RTOG study of the palliation of symptomatic osseous metastasis. Cancer. 1985;55:1468–1472
  31. Wu JSY, Bezjak A, Chow E, et al.  Primary treatment endpoint following palliative radiotherapy for painful bone metastases (Need for a consensus definition?). Clin Oncol (R Coll Radiol). 2002;14:70–77
  32. International Bone Metastases Consensus Working Party . International bone metastases consensus on endpoint measurements for future clinical trials (Proceedings of the first survey and meeting (work in progress)). Clin Oncol (R Coll Radiol). 2001;13:82–84
  33. Chow E, Wu JSY, Hoskin P, et al.  International consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases. Radiother Oncol. 2002;64:275–280

☆ Supported by Cancer Care Ontario and the Ontario Ministry of Health and Long-term Care.

PII: S0360-3016(02)04147-0

International Journal of Radiation Oncology * Biology * Physics
Volume 55, Issue 3 , Pages 594-605 , 1 March 2003

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