FDG-PET scanning after radiation can predict tumor regrowth three months later

Koike, Izumi; Ohmura, Motoko; Hata, Masaharu; Takahashi, Nobukazu; Oka, Takashi; Ogino, Ichiro; Lee, Jin; Umezawa, Tomoko; Kinbara, Kazuhiro; Watai, Kiichi; Ozawa, Yukihiko; Inoue, Tomio

doi:10.1016/S0360-3016(03)00757-0

« Previous Next »International Journal of Radiation Oncology * Biology * Physics
Volume 57, Issue 5 , Pages 1231-1238, 1 December 2003

FDG-PET scanning after radiation can predict tumor regrowth three months later

Izumi Koike, M.D.
- Department of Radiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
- Reprint requests to: Izumi Koike, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. Tel: +81-45-787-2696; Fax: +81-45-786-0369
Motoko Ohmura, M.D.
- Department of Radiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
Masaharu Hata, M.D.
- Proton Medical Research Center, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
Nobukazu Takahashi, M.D.
- Department of Radiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
Takashi Oka, M.D.
- Department of Radiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
Ichiro Ogino, M.D.
- Department of Radiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
Jin Lee, M.D.
- Department of Radiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
Tomoko Umezawa, M.D.
- Department of Radiology, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan
Kazuhiro Kinbara, M.D.
- Department of Radiology, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan
Kiichi Watai, M.D.
- Department of Radiology, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan
Yukihiko Ozawa, M.D.
- Department of Radiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
Tomio Inoue, M.D.
- Department of Radiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan

Received 28 October 2002; received in revised form 29 May 2003; accepted 9 June 2003.

Abstract

Purpose

Positron emission tomography (PET) with 2-[¹⁸F]fluoro-2-deoxy-d-glucose (FDG) is well known for providing excellent clinical information regarding malignant tumors. We investigated whether dual-time FDG-PET performed immediately post radiation could predict early regrowth of malignant tumors.

Methods and materials

Twenty patients with malignant tumors were included in this study. All patients received radiation, and each underwent FDG-PET before the initiation of therapy and within 10 days of completing their course of irradiation. PET images after irradiation were obtained at 60 min and 180 min post FDG injection. For 26 lesions in 20 patients, standardized uptake value (SUV) before and after treatment was calculated and then correlated with postradiation tumor response and outcome at 3 months status post irradiation.

Results

Retention index [RI = (SUV on delayed image − SUV on early image)/SUV on early image] after irradiation showed a significant difference between patients with residual tumor and those without residual tumor at 3 months status post irradiation (p < 0.0025). All 9 lesions in 6 patients with residual tumors showed more than 0.1 of RI, whereas none of the lesions with less than 0.1 of RI revealed residual tumors.