International Journal of Radiation Oncology * Biology * Physics
Volume 57, Issue 5 , Pages 1247-1253 , 1 December 2003

Ongoing clinical experience utilizing 3D conformal external beam radiotherapy to deliver partial-breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy

  • Frank A Vicini, M.D.

      Affiliations

    • Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    • Corresponding Author InformationReprint requests to: Frank A. Vicini, M.D., Department of Radiation Oncology, William Beaumont Hospital, 3601 W. 13 Mile Rd., Royal Oak, MI 48072, USA. Tel: (248) 551-1219; Fax: (248) 551-0089
    • ,
  • Vincent Remouchamps, M.D.

      Affiliations

    • Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    • ,
  • Michelle Wallace, R.N.

      Affiliations

    • Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    • ,
  • Michael Sharpe, Ph.D.

      Affiliations

    • Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    • ,
  • Julie Fayad, M.S.
    • ,
  • Laura Tyburski
    • ,
  • Nicola Letts, B.Sc.
    • ,
  • Larry Kestin, M.D.
    • ,
  • Gregory Edmundson, M.Sc.

      Affiliations

    • Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    • ,
  • Jane Pettinga, M.D.

      Affiliations

    • Department of Surgery, William Beaumont Hospital, Royal Oak, Michigan, USA
    • ,
  • Neal S Goldstein, M.D.

      Affiliations

    • Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan, USA
    • ,
  • John Wong, Ph.D.

      Affiliations

    • Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA

Received 27 March 2003 ,Revised 23 May 2003 ,Accepted 30 May 2003.

References 

  1. Veronesi U, Cascinelli N, Mariani L, et al.  Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347(16):1227–1232
  2. Fisher B, Anderson S, Bryant J, et al.  Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347(16):1233–1241
  3. Rosen PP, Fracchia AA, Urban JA, et al.  “Residual” mammary carcinoma following simulated partial mastectomy. Cancer. 1975;35(3):739–747
  4. Keisch M, Vicini F, Kuske RR, et al.  Initial clinical experience with the MammoSite breast brachytherapy applicator in women with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2003;55(2):289–293
  5. Baglan KL, Sharpe MB, Jaffray D, et al.  Accelerated partial breast irradiation using 3D conformal radiation therapy (3D-CRT). Int J Radiat Oncol Biol Phys. 2003;55(2):302–311
  6. Dale RG. The application of the linear-quadratic dose-effect equation to fractionated and protracted radiotherapy. Br J Radiol. 1985;58(690):515–528
  7. Moon WK, Noh DY, Im JG. Multifocal, multicentric, and contralateral breast cancers (Bilateral whole-breast US in the preoperative evaluation of patients). Radiology. 2002;224(2):569–576
  8. Orel SG, Schnall MD, Powell CM, et al.  Staging of suspected breast cancer (Effect of MR imaging and MR-guided biopsy). Radiology. 1995;196(1):115–122
  9. Smith TE, Lee D, Turner BC, et al.  True recurrence vs. new primary ipsilateral breast tumor relapse (An analysis of clinical and pathologic differences and their implications in natural history, prognoses, and therapeutic management). Int J Radiat Oncol Biol Phys. 2000;48(5):1281–1289
  10. Morrow M. Rational local therapy for breast cancer. N Engl J Med. 2002;347(16):1270–1271
  11. King TA, Bolton JS, Kuske RR, et al.  Long-term results of wide-field brachytherapy as the sole method of radiation therapy after segmental mastectomy for T(is, 1, 2) breast cancer. Am J Surg. 2000;180(4):299–304
  12. Polgar C, Sulyok Z, Fodor J, et al.  Sole brachytherapy of the tumor bed after conservative surgery for T1 breast cancer (Five-year results of a phase I-II study and initial findings of a randomized phase III trial). J Surg Oncol. 2002;80(3):121–128
  13. Vicini FA, Baglan KL, Kestin LL, et al.  Accelerated treatment of breast cancer. J Clin Oncol. 2001;19(7):1993–2001
  14. Veronesi U, Orecchia R, Luini A, et al.  A preliminary report of intraoperative radiotherapy (IORT) in limited-stage breast cancers that are conservatively treated. Eur J Cancer. 2001;37(17):2178–2183
  15. Vaidya JS, Baum M, Tobias JS, et al.  Targeted intra-operative radiotherapy (Targit) (An innovative method of treatment for early breast cancer). Ann Oncol. 2001;12(8):1075–1080
  16. Baglan KL, Martinez AA, Frazier RC, et al.  The use of high-dose-rate brachytherapy alone after lumpectomy in patients with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2001;50(4):1003–1011
  17. Fentiman IS, Poole C, Tong D, et al.  Iridium implant treatment without external radiotherapy for operable breast cancer (A pilot study). Eur J Cancer. 1991;27(4):447–450
  18. Fentiman IS, Poole C, Tong D, et al. Inadequacy of iridium implant as sole radiation treatment for operable breast cancer. Eur J Cancer 1996;32A(4):608–611
  19. Kuske RR. Breast brachytherapy. Hematol Oncol Clin North Am 1999;13(3):543–vii
  20. Wazer DE, Lowther D, Boyle T, et al.  Clinically evident fat necrosis in women treated with high-dose-rate brachytherapy alone for early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2001;50(1):107–111
  21. Cionini L, Pacini P, Marzano S. Exclusive brachytherapy after conservative surgery in cancer of the breast. Lyon Chir. 1993;89:128
  22. Krishnan L, Jewell WR, Tawfik OW, et al.  Breast conservation therapy with tumor bed irradiation alone in a selected group of patients with stage I breast cancer. Breast J. 2001;7(2):91–96
  23. Wazer DE, Berle L, Graham R, et al.  Preliminary results of a phase I/II study of HDR brachytherapy alone for T1/T2 breast cancer. Int J Radiat Oncol Biol Phys. 2002;53(4):889–897
  24. Formenti SC, Rosenstein B, Skinner KA, et al.  T1 stage breast cancer (Adjuvant hypofractionated conformal radiation therapy to tumor bed in selected postmenopausal breast cancer patients—pilot feasibility study). Radiology. 2002;222(1):171–178
  25. Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: An overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group. Lancet 2000;355(9217):1757–1770

☆ The authors thank the William Beaumont Hospital Foundation and the Alfred Berkowitz Foundation for their generous support of this research.

PII: S0360-3016(03)01573-6

doi: 10.1016/S0360-3016(03)01573-6

International Journal of Radiation Oncology * Biology * Physics
Volume 57, Issue 5 , Pages 1247-1253 , 1 December 2003

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