International Journal of Radiation Oncology * Biology * Physics
Volume 59, Issue 3 , Pages 834-843 , 1 July 2004

Effect of RSR13, an allosteric hemoglobin modifier, on oxygenation in murine tumors: an in vivo electron paramagnetic resonance oximetry and bold MRI study

Presented in part at the 11th Annual Meeting of the International Society for Magnetic Resonance in Medicine, Toronto, ON, Canada, July 2003, and at the 31st Annual Meeting of the International Society on Oxygen Transport to Tissue, Rochester, NY, August 2003.

  • Huagang Hou, M.D.

      Affiliations

    • Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    • ,
  • Nadeem Khan, Ph.D.

      Affiliations

    • Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    • ,
  • Julia A O'Hara, Ph.D.

      Affiliations

    • Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    • ,
  • Oleg Y Grinberg, Ph.D.

      Affiliations

    • Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    • ,
  • Jeff F Dunn, Ph.D.

      Affiliations

    • Department of Diagnostic Radiology, Biomedical NMR Laboratory, Dartmouth Medical School, Hanover, NH, USA
    • ,
  • Michelle A Abajian, B.S.

      Affiliations

    • Department of Diagnostic Radiology, Biomedical NMR Laboratory, Dartmouth Medical School, Hanover, NH, USA
    • ,
  • Carmen M Wilmot, B.S.

      Affiliations

    • Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    • ,
  • Malek Makki, Ph.D.

      Affiliations

    • Department of Diagnostic Radiology, Biomedical NMR Laboratory, Dartmouth Medical School, Hanover, NH, USA
    • ,
  • Eugene Demidenko, Ph.D.

      Affiliations

    • Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH, USA
    • ,
  • Shiyi Lu, Ph.D.

      Affiliations

    • Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    • ,
  • Robert P Steffen, Ph.D.

      Affiliations

    • Allos Therapeutics, Inc., Westminster, CO, USA
    • ,
  • Harold M Swartz, M.D., Ph.D.

      Affiliations

    • Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    • Corresponding Author InformationReprint requests to: Harold M. Swartz, M.D, Ph.D., Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA. Tel: (603) 650-1955; Fax: (603) 650-1717

Received 24 September 2003 ,Revised 17 February 2004 ,Accepted 18 February 2004.

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☆ This work was supported by Allos Therapeutics, Inc. and NIH (NIBIB) grant P01 EB002180, and used the facilities of the EPR Center for the Study of Viable Systems supported by NIH (NIBIB) Grant P41 EB002032.

PII: S0360-3016(04)00358-X

doi: 10.1016/j.ijrobp.2004.02.039

International Journal of Radiation Oncology * Biology * Physics
Volume 59, Issue 3 , Pages 834-843 , 1 July 2004

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