International Journal of Radiation Oncology * Biology * Physics
Volume 61, Issue 4 , Pages 993-1002 , 15 March 2005

Dose–response characteristics of low- and intermediate-risk prostate cancer treated with external beam radiotherapy

Presented at the 46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), October 3–7, 2004, Atlanta, GA.

  • Rex Cheung, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • Corresponding Author InformationReprint requests to: Rex Cheung, M.D., Ph.D., Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 97, Houston, TX 77030-4009. Tel: (713) 563-2339; Fax: (713) 563-2366
    • ,
  • Susan L. Tucker, Ph.D.

      Affiliations

    • Department of Biostatistics and Applied Mathematics, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Andrew K. Lee, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Renaud de Crevoisier, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Lei Dong, Ph.D.

      Affiliations

    • Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Ashish Kamat, M.D.

      Affiliations

    • Department of Urology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Louis Pisters, M.D.

      Affiliations

    • Department of Urology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Deborah Kuban, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Received 23 March 2004 ,Revised 19 July 2004 ,Accepted 23 July 2004.

References 

  1. Hanks GE , Teshima T , Pajak TF . 20 years of progress in radiation oncology: Prostate cancer . Semin Radiat Oncol . 1997;7:114–120
  2. Zelefsky MJ , Fuks Z , Hunt M , et al.  High dose radiation delivered by intensity modulated conformal radiotherapy improves the outcome of localized prostate cancer . J Urol . 2001;166:876–881
  3. Pollack A , Zagars GK , Starkschall G , et al.  Prostate cancer radiation dose response: Results of the M (D. Anderson phase III randomized trial) . Int J Radiat Oncol Biol Phys . 2002;53:1097–1105
  4. Levegrun S , Jackson A , Zelefsky MJ , et al.  Risk group dependence of dose-response for biopsy outcome after three-dimensional conformal radiation therapy of prostate cancer . Radiother Oncol . 2002;63:11–26
  5. Pollack A , Smith LG , von Eschenbach AC . External beam radiotherapy dose response characteristics of 1127 men with prostate cancer treated in the PSA era . Int J Radiat Oncol Biol Phys . 2000;48:507–512
  6. Lyons JA , Kupelian PA , Mohan DS , et al.  Importance of high radiation doses (72 Gy or greater) in the treatment of stage T1-T3 adenocarcinoma of the prostate . Urology . 2000;55:85–90
  7. Hurwitz MD , Schnieder L , Manola J , et al.  Lack of radiation dose response for patients with low-risk clinically localized prostate cancer: A retrospective analysis . Int J Radiat Oncol Biol Phys . 2002;53:1106–1110
  8. Pollack A , Hanlon AL , Horwitz EM , et al.  Prostate cancer radiotherapy dose response: An update of the Fox Chase experience . J Urol . 2004;171:1132–1136
  9. Thames H , Kuban D , Levy L , et al.  Comparison of alternative biochemical failure definitions based on clinical outcome in 4839 prostate cancer patients treated by external beam radiotherapy between 1986 and 1995 . Int J Radiat Oncol Biol Phys . 2003;57:929–943
  10. Pollack A , Zagars GK . External beam radiotherapy dose response of prostate cancer . Int J Radiat Oncol Biol Phys . 1997;39:1011–1018
  11. Cheung R , Tucker SL , Dong L , et al.  Dose-response for biochemical control among high-risk prostate cancer patients after external beam radiotherapy . Int J Radiat Oncol Biol Phys . 2003;56:1234–1240
  12. American Society for Therapeutic Radiology and Oncology Consensus Panel . Consensus statement: Guidelines for PSA following radiation therapy . Int J Radiat Oncol Biol Phys . 1997;37:1035–1041
  13. Kuban DA , Thames HD , Levy LB , et al.  Long-term multi-institutional analysis of stage T1-T2 prostate cancer treated with radiotherapy in the PSA era . Int J Radiat Oncol Biol Phys . 2003;57:915–928
  14. Kaplan EL , Meier P . Nonparametric estimation of incomplete observations . J Am Stat Assoc . 1958;53:457–481
  15. Carmelli D , Halpern J , Swan GE , et al.  27-year mortality in the Western Collaborative Group study: Construction of risk groups by recursive partitioning . J Clin Epidemiol . 1991;44:1341–1351
  16. Cheung R, Tucker SL, Lee AK, et al. Assessing the impact of an alternative biochemical failure definition on radiation dose response for high-risk prostate cancer treated with external beam radiotherapy. Int J Radiat Oncol Biol Phys 2005;61:14–19.
  17. Lyons JA , Kupelian PA , Mohan DS , et al.  Importance of high radiation doses (72 Gy or greater) in the treatment of stage T1-T3 adenocarcinoma of the prostate . Urology . 2000;55:85–90
  18. Basaria S , Lieb J , Tang AM , et al.  Long-term effects of androgen deprivation therapy in prostate cancer patients . Clin Endocrinol . 2002;56:779–786
  19. Padula GD , Zelefsky MJ , Venkatraman ES , et al.  Normalization of serum testosterone levels in patients treated with neoadjuvant hormonal therapy and three-dimensional conformal radiotherapy for prostate cancer . Int J Radiat Oncol Biol Phys . 2002;52:439–443
  20. Partin AW , Pound CR , Clemens JQ , et al.  Serum PSA after anatomic radical prostatectomy: The Johns Hopkins experience after 10 years . Urol Clin North Am . 1993;20:713–725
  21. Hanlon AL , Diratzouian H , Hanks GE . Posttreatment prostate-specific antigen nadir highly predictive of distant failure and death from prostate cancer . Int J Radiat Oncol Biol Phys . 2002;53:297–303
  22. Vicini FA , Kestin LL , Martinez AA . The importance of adequate follow-up in defining treatment success after external beam irradiation for prostate cancer . Int J Radiat Oncol Biol Phys . 1999;45:553–561
  23. Kattan MW , Fearn PA , Leibel S , et al.  The definition of biochemical failure in patients treated with definitive radiotherapy . Int J Radiat Oncol Biol Phys . 2000;48:1469–1474
  24. Horwitz EM , Uzzo RG , Hanlon AL , et al.  Modifying the American Society for Therapeutic Radiology and Oncology definition of biochemical failure to minimize the influence of backdating in patients with prostate cancer treated with 3-dimensional conformal radiation therapy alone . J Urol . 2003;169:2153–2157
  25. Takamiya R , Weinberg V , Young CD , et al.  A zero PSA slope in posttreatment prostate-specific antigen supports cure of patients with long-term follow-up after external beam radiotherapy for localized prostate cancer . Int J Radiat Oncol Biol Phys . 2003;56:1073–1078

PII: S0360-3016(04)02129-7

doi: 10.1016/j.ijrobp.2004.07.723

International Journal of Radiation Oncology * Biology * Physics
Volume 61, Issue 4 , Pages 993-1002 , 15 March 2005

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