International Journal of Radiation Oncology * Biology * Physics
Volume 61, Issue 4 , Pages 1011-1018 , 15 March 2005

Gastrointestinal toxicity and its relation to dose distributions in the anorectal region of prostate cancer patients treated with radiotherapy

  • Wilma D. Heemsbergen, M.Sc.

      Affiliations

    • Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    • Corresponding Author InformationReprint requests to: Wilma D. Heemsbergen, M.Sc., Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. Tel: (+31) 20-512-2144; Fax: (+31) 20-669-1101
    • ,
  • Mischa S. Hoogeman, Ph.D.

      Affiliations

    • Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    • ,
  • Guus A.M. Hart, M.Sc.

      Affiliations

    • Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    • ,
  • Joos V. Lebesque, M.D., Ph.D.

      Affiliations

    • Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    • ,
  • Peter C.M. Koper, M.D.

      Affiliations

    • Department of Radiotherapy, Erasmus Medical Center, Rotterdam, The Netherlands

Received 6 April 2004 ,Revised 23 July 2004 ,Accepted 23 July 2004.

References 

  1. Cox J , Stetz J , Pajak TF . Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Cancer Research and Treatment of Cancer (EORTC) . Int J Radiat Oncol Biol Phys . 1995;31:1341–1346
  2. Boersma LJ , van den Brink M , Bruce AM , et al.  Estimation of the incidence of late bladder and rectum complications after high-dose (70–78 Gy) conformal radiotherapy for prostate cancer, using dose–volume histograms . Int J Radiat Oncol Biol Phys . 1998;41:83–92
  3. Fiorino C , Cozzarini C , Vavassori V , et al.  Relationships between DVHs and later rectal bleeding after radiotherapy for prostate cancer: Analysis of a large group of patients pooled from three institutions . Radiother Oncol . 2002;64:1–12
  4. Fiorino C , Sanguineti G , Cozzarini C , et al.  Rectal dose–volume constraints in high-dose radiotherapy of localized prostate cancer . Int J Radiat Oncol Biol Phys . 2003;57:953–962
  5. Skwarchuk MW , Jackson A , Zelefsky MJ , et al.  Late rectal toxicity after conformal radiotherapy of prostate cancer (I): Multivariate analysis and dose-response . Int J Radiat Oncol Biol Phys . 2000;47:103–113
  6. Jackson A , Skwarchuk MW , Zelefsky J , et al.  Late rectal bleeding after conformal radiotherapy of prostate cancer (II): Volume effects and dose–volume histograms . Int J Radiat Oncol Biol Phys . 2001;49:685–698
  7. Greco C , Mazzetta C , Cattani F , et al.  Finding dose-volume constraints to reduce late rectal toxicity following 3D-conformal radiotherapy (3D-CRT) of prostate cancer . Radiother Oncol . 2003;69:215–222
  8. Wachter S , Gerstner N , Goldner G , et al.  Rectal sequelae after conformal radiotherapy of prostate cancer: Dose-volume histograms as predictive factors . Radiother Oncol . 2001;59:65–70
  9. Koper PC , Heemsbergen WD , Hoogeman MS , et al.  Impact of volume and location of irradiated rectum wall on rectal blood loss after radiotherapy of prostate cancer . Int J Radiat Oncol Biol Phys . 2004;58:1072–1082
  10. Huang EH , Pollack A , Levy L , et al.  Late rectal toxicity: Dose–volume effects of conformal radiotherapy for prostate cancer . Int J Radiat Oncol Biol Phys . 2002;54:1314–1321
  11. Vargas C , Kestin LL , Yan D , et al.  Dose–volume analysis of predictors for chronic rectal toxicity following treatment of prostate cancer with high-dose conformal radiotherapy . Int J Radiat Oncol Biol Phys . 2003;57(Suppl.):S398–S399
  12. Fenwick JD , Khoo VS , Nahum AE , et al.  Correlations between dose–surface histograms and the incidence of long-term rectal bleeding following conformal or conventional radiotherapy treatment of prostate cancer . Int J Radiat Oncol Biol Phys . 2001;49:473–480
  13. Hoogeman MS , van Herk M , de Bois J , et al.  Quantification of local rectal wall displacements by virtual rectum unfolding . Radiother Oncol . 2004;70:21–30
  14. Koper PC , Stroom JC , van Putten WL , et al.  Acute morbidity reduction using 3DCRT for prostate carcinoma: A randomized study . Int J Radiat Oncol Biol Phys . 1999;43:727–734
  15. Tait DM , Nahum AE , Meyer LC , et al.  Acute toxicity in pelvic radiotherapy: Randomized trial of conformal versus conventional treatment . Radiother Oncol . 1997;42:121–136
  16. Goldner G , Wachter-Gerstner N , Wachter S , et al.  Acute side effects during 3-D-planned conformal radiotherapy of prostate cancer . Stralenther Onkol . 2003;179:320–327
  17. Meijer GJ , van den Brink M , Hoogeman MS , et al.  Dose–wall histograms and normalized dose-surface histograms for the rectum: A new method to analyze the dose distribution over the rectum in conformal radiotherapy . Int J Radiat Oncol Biol Phys . 1999;45:1073–1080
  18. Collett D . Modelling survival data in medical research . London: Chapman & Hall; 1994; p. 243–246
  19. Dale E , Olsen DR , Fossa SD . Normal tissue complication probabilities correlated with late effects in the rectum after prostate conformal radiotherapy . Int J Radiat Oncol Biol Phys . 1999;43:385–391
  20. Yeoh EEK , Botten R , Russo A , et al.  Chronic effects of therapeutic irradiation for localized prostate carcinoma on anorectal function . Int J Radiat Oncol Biol Phys . 2000;47:915–924
  21. Varma JS , Smith AN , Busuttil A . Function of the anal sphincters after chronic radiation injury . Gut . 1986;27:528–533
  22. Berndtsson I , Lennernas B , Hulten L . Anorectal function after modern conformal radiation therapy for prostate cancer: A pilot study . Tech Coloproctol . 2002;6:101–104
  23. Hayne D , Vaizey CJ , Boulos PB . Anorectal injury following pelvic radiotherapy . Br J Surg . 2001;88:1037–1048
  24. Vordermark D , Schwab M , Ness-Dourdoumas R , et al.  Association of anorectal dose-volume histograms and impaired fecal continence after 3D conformal radiotherapy for carcinoma of the prostate . Radiother Oncol . 2003;69:209–214

 Supported by Grant 98-1830 from the Dutch Cancer Society.

PII: S0360-3016(04)02130-3

doi: 10.1016/j.ijrobp.2004.07.724

International Journal of Radiation Oncology * Biology * Physics
Volume 61, Issue 4 , Pages 1011-1018 , 15 March 2005

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