International Journal of Radiation Oncology * Biology * Physics
Volume 61, Issue 1 , Pages 5-6 , January 2005

Testing new chemoradiation regimens for head-and-neck cancer

  • Avraham Eisbruch, M.D.

      Affiliations

    • Department of Radiation Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI
    • Corresponding Author InformationReprint requests to: Avraham Eisbruch, M.D., Department of Radiation Oncology, University of Michigan Hospital, UH B2 C440, 1500 E Medical Center Drive, Ann Arbor, MI 48109-0010. Tel: (734) 936-9337; Fax: (734) 763-7370
    • ,
  • Daniel P. Normolle, Ph.D.

      Affiliations

    • Department of Radiation Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI
    • Biostatistics Unit, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI

Received 1 September 2004 ,Accepted 7 September 2004.

References 

  1. Forastiere AA , Goepfert H , Maor M . Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer . N Engl J Med . 2003;349:2091–2098
  2. Pignon JP , Bourhis J , Domenge C , Designe L . Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: Three meta-analyses of updated individual data (MACH-NC Collaborative Group. Meta-analysis of chemotherapy on head and neck cancer) . Lancet . 2000;355:949–955
  3. Cooper JS , Pajak TF , Forastiere AA , et al.  Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck . N Engl J Med . 2004;350:1937–1944
  4. Vokes EE , Kies MS , Haraf DJ , et al.  Concomitant chemoradiotherapy as primary therapy for locoregionally advanced head and neck cancer . J Clin Oncol . 2000;18:1652–1661
  5. Eisbruch A , Shewach DS , Bradford CR , et al.  Gemcitabine concurrent with irradiation for locally advanced head and neck cancer: A phase I trial and intracellular drug incorporation study . J Clin Oncol . 2001;19:792–799
  6. Van den Bogaert W , van der Schueren E , Horiot JC , et al.  The EORTC randomized trial on three fractions per day and misonidazole in advanced head and neck cancer: Long-term results and side effects . Radiother Oncol . 1995;35:91–99
  7. Henke M , Laszig R , Rube C , et al.  Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: Randomised, double-blind, placebo-controlled trial . Lancet . 2003;362:1255–1260
  8. Warde P , O'Sullivan B , Aslanidis J , et al.  A Phase III placebo-controlled trial of oral pilocarpine in patients undergoing radiotherapy for head-and-neck cancer . Int J Radiat Oncol Biol Phys . 2002;54:9–13
  9. Haffty BG, Wilson LD, Son YH, et al. Concurrent chemo-radiotherapy with mitomycin-C compared with porfiromycin in squamous cell cancer of the head and neck: Final results of a randomized clinical trial. Int J Radiat Oncol Biol Phys 2005;61:121–130.
  10. Brizel DM , Albers ME , Fisher SR , et al.  Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer . N Engl J Med . 1998;338:1798–1804

PII: S0360-3016(04)02674-4

doi: 10.1016/j.ijrobp.2004.09.029

International Journal of Radiation Oncology * Biology * Physics
Volume 61, Issue 1 , Pages 5-6 , January 2005

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