International Journal of Radiation Oncology * Biology * Physics
Volume 61, Issue 1 , Pages 10-13 , January 2005

Novel use of zebrafish as a vertebrate model to screen radiation protectors and sensitizers

Presented at AACR 95th annual meeting.

  • Mary Frances McAleer, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA
    • Corresponding Author InformationReprint requests to: Adam Paul Dicker, M.D., Ph.D., Department of Radiation Oncology, Thomas Jefferson University, Bodine Center for Cancer Treatment, 111 South 11th Street, Philadelphia, PA 19107. Tel: (215) 955-6527; Fax: (215) 955-0412
  • ,
  • Christian Davidson, B.S.

      Affiliations

    • Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA
  • ,
  • William Robert Davidson, M.S.

      Affiliations

    • Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA
  • ,
  • Brad Yentzer, B.S.

      Affiliations

    • Department of Dermatology, Thomas Jefferson University, Philadelphia, PA
  • ,
  • Steven A. Farber, Ph.D.

      Affiliations

    • Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA
  • ,
  • Ulrich Rodeck, M.D.

      Affiliations

    • Department of Dermatology, Thomas Jefferson University, Philadelphia, PA
  • ,
  • Adam P. Dicker, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA

Received 21 May 2004 ,Revised 8 September 2004 ,Accepted 10 September 2004.

References 

  1. Stern HM , Zon LI . Cancer genetics and drug discovery in the zebrafish . Nat Rev Cancer . 2003;3:533–539
  2. Walker C , Streisinger G . Induction of mutations by γ-rays in pregonial germ cells of zebrafish embryos . Genetics . 1983;103:125–136
  3. Kimmel CB , Ballard WW , Kimmel SR , et al.  Stages of embryonic development of the zebrafish . Development Dyn . 1995;203:253–310
  4. Andreassen CN , Grau C , Lindegaard JC . Chemical radioprotection: A critical review of amifostine as a cytoprotector in radiotherapy . Semin Radiat Oncol . 2003;13:62–72
  5. Schmidt-Ullrich RK , Contessa JN , Lammering G , et al.  ErbB receptor tyrosine kinases and cellular radiation responses . Oncogene . 2003;22:5855–5865
  6. Westerfield M . The zebrafish book: A guide for the laboratory use of zebrafish Danio (Brachydanio) rerio . Eugene, OR: University of Oregon Press; 1995;
  7. Haffter P , Granato M , Brand M , et al.  The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio . Development . 1996;123:1–36
  8. Ikegami R , Hunter P , Yager TD . Developmental activation of the capability to undergo checkpoint-induced apoptosis in the early zebrafish embryo . Development Biol . 1999;209:409–433

 Supported by Commonwealth of Pennsylvania Tobacco Settlement Act, R01 CA106633-01, DAMD17-02-1-0216; and NCI/NIH/DHHS R25 CA48010.

PII: S0360-3016(04)02680-X

doi: 10.1016/j.ijrobp.2004.09.046

International Journal of Radiation Oncology * Biology * Physics
Volume 61, Issue 1 , Pages 10-13 , January 2005