International Journal of Radiation Oncology * Biology * Physics
Volume 61, Issue 1 , Pages 7-9 , January 2005

Concomitant chemotherapy and radiation therapy certainly improves local control

  • Jay S. Cooper, M.D.

      Affiliations

    • Maimonides Medical Center, Brooklyn, NY
    • Corresponding Author InformationCorrespondence to: Jay S. Cooper, 425 Riverside Drive, New York, NY 10025
    • ,
  • K. Kian Ang, M.D., Ph.D.

      Affiliations

    • The University of Texas, M.D Anderson Cancer Center, Houston, TX

Received 30 August 2004 ,Accepted 7 September 2004.

References 

  1. Adelstein DJ , Li Y , Adams GL , et al.  An Intergroup Phase III comparison of standard radiation therapy and two schedules of concurrent chemotherapy in patients with unresectable squamous cell head and neck cancer . J Clin Oncol . 2003;21:92–98
  2. Bachaud JM , Cohen-Jonathan E , Alzieu C , David JM , Serrano E , Daly-Schveitzer N . Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced head and neck carcinoma: Final report of a randomized trial . Int J Radiat Oncol Biol Phys . 1996;36:999–1004
  3. Bernier J, Domenge C, Eschwege F, et al. Chemo-radiotherapy, as compared to radiotherapy alone, significantly increases disease-free and overall survival in head and neck cancer patients after surgery: Results of EORTC phase III trial 22931. [Abstract] Int J Radiat Oncol Biol Phys 2001;51(Suppl.):1.
  4. Brizel DM , Albers ME , Fisher SR , et al.  Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer . N Engl J Med . 1998;338:1798–1804
  5. Calais G , Alfonsi M , Bardet E , et al.  Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma . J Natl Cancer Inst . 1999;91:2081–2086
  6. Cooper JS , Pajak TF , Forastiere AA , et al.  Postoperative concurrent radiation therapy and chemotherapy in high-risk squamous cell carcinoma of the head & neck: The RTOG 9501/Intergroup Phase III Trial . N Engl J Med . 2004;350:1937–1944
  7. Forastiere AA , Goepfert H , Maor M , et al.  Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer . N Engl J Med . 2003;349:2091–2098
  8. Jeremic B , Shibamoto Y , Milicic B , et al.  Hyperfractionated radiation therapy with or without concurrent low-dose daily cisplatin in locally advanced squamous cell carcinoma of the head and neck: A prospective randomized trial . J Clin Oncol . 2000;18:1458–1464
  9. Smid L , Budihna M , Zakotnik B , et al.  Postoperative concomitant irradiation and chemotherapy with mitomycin C And bleomycin for advanced head-and-neck carcinoma . Int J Radiat Oncol Biol Phys . 2003;56:1055–1062
  10. Wendt TG , Grabenbauer GG , Rodel CM , et al.  Simultaneous radiochemotherapy versus radiotherapy alone in advanced head and neck cancer: A randomized multicenter study . J Clin Oncol . 1998;16:1318–1324
  11. Bernier J , Bentzen SM . Altered fractionation and combined radio-chemotherapy approaches: Pioneering new opportunities in head and neck oncology . Eur J Cancer . 2003;39:560–571

PII: S0360-3016(04)02686-0

doi: 10.1016/j.ijrobp.2004.09.034

International Journal of Radiation Oncology * Biology * Physics
Volume 61, Issue 1 , Pages 7-9 , January 2005

Article Tools