International Journal of Radiation Oncology * Biology * Physics
Volume 62, Issue 2 , Pages 606-613 , 1 June 2005

Initial clinical results of an in vivo dosimeter during external beam radiation therapy

  • Charles W. Scarantino, M.D., Ph.D.

      Affiliations

    • Sicel Technologies Inc., Morrisville, NC, USA
    • Radiation Oncology, Rex Cancer Center, Raleigh, NC, USA
    • Corresponding Author InformationReprint requests to: Charles W. Scarantino, M.D., Ph.D., Sicel Technologies Inc., 3800 Gateway Centre Boulevard, Suite 308, Morrisville, NC 27560. Tel: (919) 465-2236 ext. 235; Fax: (919) 465-0153
  • ,
  • Christopher J. Rini, M.S.

      Affiliations

    • Sicel Technologies Inc., Morrisville, NC, USA
  • ,
  • Migdalia Aquino, B.S.

      Affiliations

    • Sicel Technologies Inc., Morrisville, NC, USA
  • ,
  • Tammy B. Carrea, B.S.

      Affiliations

    • Sicel Technologies Inc., Morrisville, NC, USA
  • ,
  • Robert D. Ornitz, M.D.

      Affiliations

    • Radiation Oncology, Rex Cancer Center, Raleigh, NC, USA
  • ,
  • Mitchell S. Anscher, M.D.

      Affiliations

    • Radiation Oncology, Duke University Medical Center, Durham, NC
  • ,
  • Robert D. Black, Ph.D.

      Affiliations

    • Sicel Technologies Inc., Morrisville, NC, USA

Received 29 April 2004 ,Revised 16 September 2004 ,Accepted 22 September 2004.

References 

  1. Bartelink H , Breur K , Hart G . Radiotherapy of lymph node metastases in patients with squamous cell carcinoma of the head-and-neck region . Int J Radiat Oncol Biol Phys . 1982;8:983–989
  2. Emami B , Lyman J , Brown A , et al.   Tolerance of normal tissue to therapeutic irradiation . Int J Radiat Oncol Biol Phys . 1991;21:109–122
  3. Fischer JJ , Moulder JE . The steepness of the dose-response curve in radiation therapy . Radiology . 1975;117:179–184
  4. Weber DC , Alouet P , Kurtz JM , Allal AS . Assessment of target dose delivery in anal cancer during in-vivo thermoluminescent dosimeter . Radiother Oncol . 2001;59:39–43
  5. Essers M , Mijnheer BJ . In vivo dosimetery during external photon beam radiotherapy . Int J Radiat Oncol Biol Phys . 1999;43:245–259
  6. Boellaard R , Essers M , van Herk M , et al.   A new method to obtain the midplane dose using portal in vivo dosimetry . Int J Radiat Oncol Biol Phys . 1998;41:465–474
  7. Heukelom S , Lanson JH , Mijnheer BJ . In vivo dosimetry during pelvic treatment . Radiother Oncol . 1992;25:111–120
  8. Leunens G , Van Dam J , Dutreix A , et al.   Quality assurance in radiotherapy by in vivo dosimetry. 2. Determination of the target absorbed dose . Radiother Oncol . 1990;19:73–87
  9. Terron JA , Sanchez-Doblado F , Arrans R , et al.   Midline dose algorithm for in vivo dosimetry . Med Dosim . 1994;19:263–267
  10. Scarantino CW , Russlander D , Rini CJ , Mann GG , Nagle HT , Black RD . An implantable radiation dosimeter for use in external beam radiation therapy . Med Phys . 2004;31:2658–2671
  11. Sontag MR , Cunningham JR . The equivalent tissue-air ratio for making absorbed dose calculations in a heterogeneous medium . Radiology . 1978;129:787–794
  12. Batho HF . Lung corrections in cobalt 60 beam therapy . J Can Assoc Radiol . 1964;15:79–83
  13. Wang L , Yorke E , Desobry G , Chui CS . Dosimetric advantage of using 6 MV or 15 MV photons in conformal therapy of lung cancer (Monte Carlo studies in patient geometries) . J Appl Clin Med Phys . 2002;3:51–59
  14. De Jaeger K , Hoogeman MS , Enlegsman M , et al.   Incorporating an improved dose calculation algorithm in conformal radiotherapy of lung cancer (Re-evaluation of dose in normal lung tissue) . Radiother Oncol . 2003;69:1–10
  15. Klein EE , Morrison A , Purdy JA , Graham MV , Matthews J . A volumetric study of measurements and calculations of lung density corrections for 6 and 18 MV photons . Int J Radiat Oncol Biol Phys . 1997;37:1163–1170
  16. Klein EE , Chin LM , Rice RK , Minjheer BJ . The influence of air cavities on interface doses for photon beams . Int J Radiat Oncol Biol Phys . 1993;27:419–427
  17. Frank SJ , Forster KM , Stevens CW , et al.   Treatment planning for lung cancer (Traditional homogeneous point-dose prescription compared with heterogeneity corrected dose-volume prescription) . Int J Radiat Oncol Biol Phys . 2003;56:1308–1318
  18. Kuriyama K , Onishi H , Sano N , et al.   A new irradiation unit constructed of self-moving gantry-CT and linac . Int J Radiat Oncol Biol Phys . 2003;55:428–435
  19. Goitein M . Organ and tumor and motion (an overview) . Sem Radiat Oncol . 2004;14:2–9
  20. Muren LP , Smaaland R , Dahl O . Organ motion, set-up variation and treatment margins, in radical radiotherapy of urinary bladder cancer . Radiother Oncol . 2003;69:291–304
  21. Van Herk M , Bruce A , Kroes APG , et al.   Quantification of organ motion during conformal radiotherapy of the prostate by three-dimensional image registration . Int J Radiat Oncol Biol Phys . 1995;33:1311–1320
  22. Roeske JC , Forman J , Mesina CF , et al.   Evaluation of changes in the size and location of the prostate, seminal vesicles, bladder, and rectum during a course of external beam radiation therapy . Int J Radiat Oncol Biol Phys . 1995;33:1321–1329
  23. Roach M , Faillace-Akazawa P , Malfatti C . Prostate volumes and organ movements defined by serial computerized tomographic scans during three-dimensional conformal radiotherapy . Radiat Oncol Invest . 1997;5:187–194
  24. Balter JM , Lam KL , McGinn CJ , et al.   Improvement of CT-based treatment-planning models of abdominal targets using static-exhale imaging . Int J Radiat Oncol Biol Phys . 1998;41:939–943
  25. Hanley J , Debois MM , Mah D , et al.   Deep inspiration breath hold technique for lung tumors (The potential value of target immobilization and reduced lung density in dose escalation) . Int J Radiat Oncol Biol Phys . 1999;45:603–611

 This work was supported in part by National Cancer Institute R21 CA97859.

PII: S0360-3016(04)02693-8

doi: 10.1016/j.ijrobp.2004.09.041

International Journal of Radiation Oncology * Biology * Physics
Volume 62, Issue 2 , Pages 606-613 , 1 June 2005