« Previous
Next »
International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 1
, Pages 38-46
, 1 January 2006
Molecular strategies targeting the host component of cancer to enhance tumor response to radiation therapy
References
-
.
In: 6th ed..
Cancer. Principles and practice of oncology
. Vol 1:
Philadelphia: Lippincott Williams & Wilkins; 2001;
- Effects of extracellular matrix on the response of endothelial cells to radiation in vitro . Eur J Cancer . 1992;28A:725–731
- Tumor response to radiotherapy regulated by endothelial cell apoptosis . Science . 2003;300:1155–1159
- Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice . Science . 2001;293:293–297
- . Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents (Exploring mechanisms of interaction) . Clin Cancer Res . 2003;9:1957–1971
- . Improving tumor response to radiotherapy by targeting angiogenesis signaling pathways . Hematol Oncol Clin North Am . 2004;18:1039–1057 viii
- Combined effects of angiostatin and ionizing radiation in antitumour therapy . Nature . 1998;394:287–291
- Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation . Cancer Res . 1999;59:3374–3378
- . Growth factor-independent activation of protein kinase B contributes to the inherent resistance of vascular endothelium to radiation-induced apoptotic response . Cancer Res . 2003;63:7663–7667
- Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation . Cancer Res . 2002;62:4671–4677
- Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy . Cancer Res . 2001;61:2413–2419
- A specific antagonist of the p110delta catalytic component of phosphatidylinositol 3′-kinase, IC486068, enhances radiation-induced tumor vascular destruction . Cancer Res . 2004;64:4893–4899
- SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models . Cancer Res . 2003;63:4009–4016
- Akt is a direct target of the phosphatidylinositol 3-kinase (Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells) . J Biol Chem . 1996;271:30835–30839
- . The PI3K-PDK1 connection (More than just a road to PKB) . Biochem J . 2000;346:561–576
- Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha . Curr Biol . 1997;7:261–269
- Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells . Oncogene . 2002;21:4032–4041
- . Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment . Endocr Relat Cancer . 2001;8:237–248
- Phosphatidylinositol 3-kinase (Structure and expression of the 110 kd catalytic subunit) . Cell . 1992;70:419–429
- A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo . Mol Cell Biol . 1993;13:5560–5566
- The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity . Mol Cell Biol . 1994;14:2675–2685
- . Tyrosine kinase signalling in breast cancer (ErbB family receptor tyrosine kinases) . Breast Cancer Res . 2000;2:176–183
- Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells . Oncogene . 2000;19:1647–1656
- . Heregulin-stimulated acetylcholine receptor gene expression in muscle (Requirement for MAP kinase and evidence for a parallel inhibitory pathway independent of electrical activity) . Embo J . 1997;16:717–725
- . Lipid-regulated kinases (Some common themes at last) . Science . 1998;279:673–674
- Mechanism of activation of protein kinase B by insulin and IGF-1 . Embo J . 1996;15:6541–6551
- . Structure and function of phosphoinositide 3-kinases . Biochim Biophys Acta . 1998;1436:127–150
- . The phosphatidylinositol 3-kinase AKT pathway in human cancer . Nat Rev Cancer . 2002;2:489–501
- Regulation of neuronal survival by the serine-threonine protein kinase Akt . Science . 1997;275:661–665
- Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery . Cell . 1997;91:231–241
- Differential activation of the phosphatidylinositol 3′-kinase/Akt survival pathway by ionizing radiation in tumor and primary endothelial cells . Cancer Res . 2004;64:5398–5406
- . Receptor tyrosine kinase inhibitors as anti-angiogenic agents . Curr Opin Investig Drugs . 2004;5:597–604
- Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors . Cancer Res . 1999;59:5209–5218
- . Growth factors in glioma angiogenesis (FGFs, PDGF, EGF, and TGFs) . J Neurooncol . 2000;50:121–137
- Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo . Cancer Res . 1994;54:2582–2590
- Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries (An autocrine mechanism contributing to angiogenesis) . J Cell Biol . 1998;141:1659–1673
- . Vascular endothelial growth factor in human glioma cell lines (Induced secretion by EGF, PDGF-BB, and bFGF) . J Neurosurg . 1995;82:864–873
- Effects of irradiation on the release of growth factors from cultured bovine, porcine, and human endothelial cells . Cancer Res . 1989;49:5066–5072
- . Cell signaling by receptor tyrosine kinases . Cell . 2000;103:211–225
- . Signal transduction by the PDGF receptors . Prog Growth Factor Res . 1994;5:37–54
- . Platelet-derived growth factor receptor signals . J Biol Chem . 1994;269:32023–32026
- . Potential role for epidermal growth factor receptor inhibitors in combined-modality therapy for non-small-cell lung cancer . Int J Radiat Oncol Biol Phys . 2004;59:11–20
- Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts . Cancer Res . 2001;61:39–44
- SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro . Cancer Res . 2003;63:3755–3763
- Triple combination of irradiation, chemotherapy (pemetrexed), and VEGFR inhibition (SU5416) in human endothelial and tumor cells . Int J Radiat Oncol Biol Phys . 2004;60:1220–1232
- Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer . N Engl J Med . 2004;350:2335–2342
- RhuMab VEGF (Bevacizumab) with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer (An active, well tolerated regimen) . Int J Radiat Oncol Biol Phys . 2004;60(Suppl. 1):S149
- PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration . Cancer Res . 2000;60:2178–2189
- Effect of VEGF receptor inhibitor PTK787/ZK222584 combined with ionizing radiation on endothelial cells and tumour growth . Br J Cancer . 2001;85:2010–2016
-
SU6668 inhibits Flk-1/KDR and PDGFRbeta in vivo, resulting in rapid apoptosis of tumor vasculature and tumor regression in mice
.
Faseb J
. 2002;16:681–690
- SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors . Cancer Res . 2000;60:4152–4160
- Simultaneous inhibition of the receptor kinase activity of vascular endothelial, fibroblast, and platelet-derived growth factors suppresses tumor growth and enhances tumor radiation response . Cancer Res . 2002;62:1702–1706
- Broad spectrum receptor tyrosine kinase inhibitor, SU6668, sensitizes radiation via targeting survival pathway of vascular endothelium . Int J Radiat Oncol Biol Phys . 2004;58:844–850
- In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors (Determination of a pharmacokinetic/pharmacodynamic relationship) . Clin Cancer Res . 2003;9:327–337
- Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002 . Int J Radiat Oncol Biol Phys . 2003;56:846–853
- Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin . Cancer Res . 1998;58:4375–4382
- Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay . Clin Cancer Res . 1997;3:1149–1156
- . The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage . Cancer Res . 1996;56:246–250
-
Sadhu C, Dick K, Treiberg J. Inhibitors of human phosphatidylinositol 3-kinase delta. US Patent Application 20020161014 2002;WO 01/81346.
- . Targeting the mammalian target of rapamycin (mTOR) (A new approach to treating cancer) . Br J Cancer . 2004;91:1420–1424
- Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance . Nature . 1997;390:404–407
- . Chemotherapy targeted to tumor vasculature . Curr Opin Oncol . 1998;10:560–565
- . Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model . Science . 1998;279:377–380
- . Alpha v integrins as receptors for tumor targeting by circulating ligands . Nat Biotechnol . 1997;15:542–546
-
Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels
.
Cancer Cell
. 2003;3:63–74
- Targeting drug delivery to radiation-induced neoantigens in tumor microvasculature . J Control Release . 2001;74:183–191
- Radiation abscopal antitumor effect is mediated through p53 . Cancer Res . 2003;63:1990–1993
- Radiation-guided drug delivery to tumor blood vessels results in improved tumor growth delay . J Control Release . 2004;99:369–381
PII: S0360-3016(05)00292-0
doi: 10.1016/j.ijrobp.2005.02.008
© 2006 Elsevier Inc. All rights reserved.
« Previous
Next »
International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 1
, Pages 38-46
, 1 January 2006
