International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 2 , Pages 363-373 , 1 February 2006

Intensity-modulated radiation therapy for the treatment of oropharyngeal carcinoma: The Memorial Sloan-Kettering Cancer Center experience

Presented at the 4th Takahashi Memorial International Workshop on 3-Dimensional Conformal Radiotherapy, Nagoya, Japan, December 8–12, 2004.

  • Fernando F. de Arruda, M.D.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • ,
  • Dev R. Puri, M.D.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • ,
  • Joanne Zhung, B.A.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • ,
  • Ashwatha Narayana, M.D.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • ,
  • Suzanne Wolden, M.D.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • ,
  • Margie Hunt, M.S.

      Affiliations

    • Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • ,
  • Hilda Stambuk, M.D.

      Affiliations

    • Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • ,
  • David Pfister, M.D.

      Affiliations

    • Department of Medical Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • ,
  • Dennis Kraus, M.D.

      Affiliations

    • Department of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • ,
  • Ashok Shaha, M.D.

      Affiliations

    • Department of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • ,
  • Jatin Shah, M.D.

      Affiliations

    • Department of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • ,
  • Nancy Y. Lee, M.D.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • Corresponding Author InformationReprint requests to: Nancy Y. Lee, M.D., Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10022. Tel: (212) 639-3341; Fax: (212) 639-2417

Received 27 January 2005 ,Revised 4 March 2005 ,Accepted 7 March 2005.

References 

  1. Parsons JT , Mendenhall WM , Stringer SP , et al.   Squamous cell carcinoma of the oropharynx (Surgery, radiation therapy, or both) . Cancer . 2002;94:2967–2980
  2. Calais G , Alfonsi M , Bardet E , et al.   Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma . [see comment] J Natl Cancer Inst . 1999;91:2081–2086
  3. Denis F , Garaud P , Bardet E , et al.   Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma . [see comment] J Clin Oncol . 2004;22:69–76
  4. Lee N , Xia P , Quivey JM , et al.   Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma (An update of the UCSF experience) . Int J Radiat Oncol Biol Phys . 2002;53:12–22
  5. Claus F , Boterberg T , Ost P , et al.   Short term toxicity profile for 32 sinonasal cancer patients treated with IMRT. Can we avoid dry eye syndrome? . Radiother Oncol . 2002;64:205–208
  6. Henson BS , Inglehart MR , Eisbruch A , et al.   Preserved salivary output and xerostomia-related quality of life in head and neck cancer patients receiving parotid-sparing radiotherapy . Oral Oncol . 2001;37:84–93
  7. Chao KS , Majhail N , Huang CJ , et al.   Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma (A comparison with conventional techniques) . Radiother Oncol . 2001;61:275–280
  8. Eisbruch A , Marsh LH , Dawson LA , et al.   Recurrences near base of skull after IMRT for head-and-neck cancer (implications for target delineation in high neck and for parotid gland sparing) . Int J Radiat Oncol Biol Phys . 2004;59:28–42
  9. Huang K , Lee N , Xia P . Intensity-modulated radiotherapy in the treatment of oropharyngeal carcinoma (A single institutional experience) . Int J Radiat Oncol Biol Phys . 2003;57:S302
  10. Fu KK , Pajak TF , Trotti A , et al.   A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas (First report of RTOG 9003) . Int J Radiat Oncol Biol Phys . 2000;48:7–16
  11. Spirou SV , Chui CS . A gradient inverse planning algorithm with dose-volume constraints . Med Phys . 1998;25:321–333
  12. Mohan R , Barest G , Brewster LJ , et al.   A comprehensive three-dimensional radiation treatment planning system . Int J Radiat Oncol Biol Phys . 1988;15:481–495
  13. Spirou SV , Chui CS . Generation of arbitrary intensity profiles by dynamic jaws or multileaf collimators . Med Phys . 1994;21:1031–1041
  14. Cox JD , Stetz J , Pajak TF . Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) . Int J Radiat Oncol Biol Phys . 1995;31:1341–1346
  15. Chao KS , Ozyigit G , Blanco AI , et al.   Intensity-modulated radiation therapy for oropharyngeal carcinoma (Impact of tumor volume) . Int J Radiat Oncol Biol Phys . 2004;59:43–50
  16. Pignon JP , Bourhis J , Domenge C , et al.   Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: Three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-analysis of chemotherapy on head and neck cancer . Lancet . 2000;355:949–955
  17. Garden AS , Morrison W , Rosenthal D , et al.   Intensity modulated radiation therapy (IMRT) for metastatic cervical adenopathy from oropharynx carcinoma . [Abstract] Int J Radiat Oncol Biol Phys . 2004;60:S318
  18. Parliament MB , Scrimger RA , Anderson SG , et al.   Preservation of oral health-related quality of life and salivary flow rates after inverse-planned intensity- modulated radiotherapy (IMRT) for head-and-neck cancer . Int J Radiat Oncol Biol Phys . 2004;58:663–673
  19. Lin A , Kim HM , Terrell JE , et al.   Quality of life after parotid-sparing IMRT for head-and-neck cancer (A prospective longitudinal study) . Int J Radiat Oncol Biol Phys . 2003;57:61–70
  20. Eisbruch A , Dawson LA , Kim HM , et al.   Conformal and intensity modulated irradiation of head and neck cancer (The potential for improved target irradiation, salivary gland function, and quality of life) . Acta Otorhinolaryngol Belg . 1999;271–275
  21. Chao KS , Deasy JO , Markman J , et al.   A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy (Initial results) . Int J Radiat Oncol Biol Phys . 2001;49:907–916
  22. Hunt MA , Jackson A , Narayana A , et al.   The relationship between parotid gland-PTV overlap and the ability to achieve dosimetric sparing of the parotid using intensity modulated radiation therapy . [Abstract] Int J Radiat Oncol Biol Phys . 2004;60:S178–S179
  23. Fisher J , Scott C , Scarantino CW , et al.   Phase III quality-of-life study results (impact on patients’ quality of life to reducing xerostomia after radiotherapy for head-and-neck cancer—RTOG 97-09) . Int J Radiat Oncol Biol Phys . 2003;56:832–836
  24. Brizel DM , Wasserman TH , Henke M , et al.   Phase III randomized trial of amifostine as a radioprotector in head and neck cancer . [see comment]. [Erratum appears in J Clin Oncol 2000;18:4110–4111]. J Clin Oncol . 2000;18:3339–3345
  25. Chao KS , Ozyigit G , Thorsdad WL . Toxicity profile of intensity-modulated radiation therapy for head and neck carcinoma and potential role of amifostine . Semin Oncol . 2003;30:101–108
  26. Johnstone PA , Niemtzow RC , Riffenburgh RH . Acupuncture for xerostomia (clinical update) . Cancer . 2002;94:1151–1156
  27. Eisbruch A , Kim HM , Terrell JE , et al.   Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer . Int J Radiat Oncol Biol Phys . 2001;50:695–704
  28. Sonis S . Oral mucositis in cancer therapy . J Support Oncol . 2004;2:3–8
  29. Adelstein DJ , Li Y , Adams GL , et al.   An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer . [see comment] J Clin Oncol . 2003;21:92–98
  30. Alvarez E , Fey EG , Valax P , et al.   Preclinical characterization of CG53135 (FGF-20) in radiation and concomitant chemotherapy/radiation-induced oral mucositis . Clin Cancer Res . 2003;9:3454–3461
  31. Antonadou D , Pepelassi M , Synodinou M , et al.   Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer . Int J Radiat Oncol Biol Phys . 2002;52:739–747
  32. Bourhis J , De Crevoisier R , Abdulkarim B , et al.   A randomized study of very accelerated radiotherapy with and without amifostine in head and neck squamous cell carcinoma . Int J Radiat Oncol Biol Phys . 2000;46:1105–1108
  33. Staar S , Rudat V , Stuetzer H , et al.   Intensified hyperfractionated accelerated radiotherapy limits the additional benefit of simultaneous chemotherapy—results of a multicentric randomized German trial in advanced head-and-neck cancer . [Erratum appears in Int J Radiat Oncol Biol Phys 2001;51:569] Int J Radiat Oncol Biol Phys . 2001;50:1161–1171
  34. Magne N , Marcy PY , Foa C , et al.   Comparison between nasogastric tube feeding and percutaneous fluoroscopic gastrostomy in advanced head and neck cancer patients . Eur Arch Oto-Rhino-Laryngol . 2001;258:89–92
  35. Anwander T , Berge S , Appel T , et al.   Percutaneous endoscopic gastrostomy for long-term feeding of patients with oropharyngeal tumors . Nutrition Cancer . 2004;50:40–45
  36. Mekhail TM , Adelstein DJ , Rybicki LA , et al.   Enteral nutrition during the treatment of head and neck carcinoma (Is a percutaneous endoscopic gastrostomy tube preferable to a nasogastric tube?) . Cancer . 2001;91:1785–1790
  37. Lee WT , Akst LM , Adelstein DJ , et al.   Risk factors for hypopharyngeal/upper esophageal stricture formation after concurrent chemoradiation . 2004; Proceedings of the Sixth International Conference on Head and Neck Cancer, August 7–11, Washington, D.C.

 Fernando F. de Arruda and Dev R. Puri contributed equally to this study.

PII: S0360-3016(05)00418-9

doi: 10.1016/j.ijrobp.2005.03.006

International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 2 , Pages 363-373 , 1 February 2006

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