« Previous
Next »
International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 1
, Pages 26-32
, 1 January 2006
Advances in understanding angiogenesis through molecular studies
References
- . Angiogenic factors . Science . 1987;235:442–447
- . What is the evidence that tumors are angiogenesis dependent? . J Natl Cancer Inst . 1990;82:4–6
- . Angiogenesis in health and disease . Nat Med . 2003;9:653–660
- . Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis . Cell . 1996;86:353–364
- Tumor development under angiogenic signaling (A dynamical theory of tumor growth, treatment response, and postvascular dormancy) . Cancer Res . 1999;59:4770–4775
- . Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors (Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal) . Proc Natl Acad Sci U S A . 1997;94:8761–8766
- . Dormancy of micrometastases (Balanced proliferation and apoptosis in the presence of angiogenesis suppression) . Nat Med . 1995;1:149–153
- Tumor dormancy in vivo by prevention of neovascularization . J Exp Med . 1972;136:261–276
- . Fundamental concepts of the angiogenic process . Curr Mol Med . 2003;3:643–651
-
Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis
.
Cancer Cell
. 2003;3:219–231
-
.
The logic of anti-angiogenic gene therapy
.
In:
Friedmann T
editors.
The development of human gene therapy
. New York: Cold Spring Harbor Laboratory Press; 1999;p. 527–543
- . Molecular targets for anti-angiogenic therapy . Curr Opin Mol Ther . 2004;6:54–70
- . Development of new drugs in angiogenesis . Curr Drug Targets . 2004;5:485–493
- Angiostatin (A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma) . Cell . 1994;79:315–328
- Endostatin (An endogenous inhibitor of angiogenesis and tumor growth) . Cell . 1997;88:277–285
- Targeted antiangiogenic therapy for cancer using Vitaxin (A humanized monoclonal antibody to the integrin alphavbeta3) . Clin Cancer Res . 2000;6:3056–3061
- Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer (Pharmacologic and long-term safety data) . J Clin Oncol . 2001;19:851–856
- . Microarray technology and gene expression analysis for the study of angiogenesis . Expert Opin Biol Ther . 2002;2:545–556
- Microarray gene expression profiling of angiogenesis inhibitors using the rat aortic ring assay . Biotechniques . 2002;33:664–666 668, 670
- Generation and degradation of human endostatin proteins by various proteinases . FEBS Lett . 2000;486:247–251
- Endostatin action and intracellular signaling (Beta-catenin as a potential target?) . Cancer Lett . 2003;196:1–12
- Phase I pharmacokinetic and pharmacodynamic study of recombinant human endostatin in patients with advanced solid tumors . J Clin Oncol . 2003;21:223–231
-
Endostatin’s antiangiogenic signaling network
.
Mol Cell
. 2004;13:649–663
- Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1 . Nat Med . 2000;6:41–48
-
Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors
.
Cancer Cell
. 2003;4:277–289
- Early genetic mechanisms underlying the inhibitory effects of endostatin and fumagillin on human endothelial cells . Genome Res . 2004;14:1585–1593
- Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth . Nature . 1990;348:555–557
- Human EZF, a Kruppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains . J Biol Chem . 1998;273:1026–1031
- Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts . Nature . 1999;401:670–677
- Molecular cloning of differentially expressed genes in human epithelial ovarian cancer . Gynecol Oncol . 1994;52:247–252
- Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer . Genomics . 2000;69:342–347
- Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan sulfate proteoglycan, perlecan, in endothelial cells . Blood . 2004;103:1185–1191
- . Heparan sulfate proteoglycans (Heavy hitters in the angiogenesis arena) . J Clin Invest . 2001;108:349–355
- Evidence for the involvement of SDF-1 and CXCR4 in the disruption of endothelial cell-branching morphogenesis and angiogenesis by TNF-alpha and IFN-gamma . J Leukoc Biol . 2004;76:217–226
- Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1 . Blood . 2002;99:2703–2711
- Prediction of in vivo synergistic activity of antiangiogenic compounds by gene expression profiling . Cancer Res . 2002;62:7143–7148
- . Technology evaluation (ABT-510, Abbott) . Curr Opin Mol Ther . 2004;6:451–457
- Inhibition of tumor growth by systemic treatment with thrombospondin-1 peptide mimetics . Int J Cancer . 2002;98:682–689
- Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells . Oncogene . 2000;19:2138–2146
- Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis . J Clin Invest . 2004;114:898–907
- Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis . J Biol Chem . 2004;279:50537–50554
- . Regulation of the calmodulin-stimulated protein phosphatase, calcineurin . J Biol Chem . 1998;273:13367–13370
-
Altered angiogenesis and survival in human tumor-derived endothelial cells
.
FASEB J
. 2003;17:1159–1161
- . The microenvironment of the tumour-host interface . Nature . 2001;411:375–379
- . Extracellular signaling through the microenvironment (A hypothesis relating carcinogenesis, bystander effects, and genomic instability) . Radiat Res . 2001;156:618–627
- Modulation of tumor-host interactions, angiogenesis, and tumor growth by tissue inhibitor of metalloproteinase 2 via a novel mechanism . Cancer Res . 2004;64:4481–4486
- . TIMP-2 (Identification and characterization of a new member of the metalloproteinase inhibitor family) . Matrix Suppl . 1992;1:299–306
- TIMP-2 mediated inhibition of angiogenesis (An MMP-independent mechanism) . Cell . 2003;114:171–180
- . Protein phosphatases and the regulation of mitogen-activated protein kinase signalling . Curr Opin Cell Biol . 2000;12:186–192
- . Protein phosphatases and the regulation of MAP kinase activity . Semin Cell Dev Biol . 1998;9:143–152
- . MAP kinases and hypoxia in the control of VEGF expression . Cancer Metastasis Rev . 2000;19:139–145
- Signaling angiogenesis via p42/p44 MAP kinase cascade . Ann N Y Acad Sci . 2000;902:187–200
- p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells . Oncogene . 1997;15:2169–2177
- . Roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the signal transduction of basic fibroblast growth factor in endothelial cells during angiogenesis . Jpn J Cancer Res . 1999;90:647–654
- Inhibition of p38 MAPK activation via induction of MKP-1 (Atrial natriuretic peptide reduces TNF-alpha-induced actin polymerization and endothelial permeability) . Circ Res . 2002;90:874–881
- . Layered expression scanning (Rapid molecular profiling of tumor samples) . Cancer Res . 2000;60:1526–1530
- The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase . Proc Natl Acad Sci U S A . 1993;90:5292–5296
- . Cycloheximide-induced cPLA(2) activation is via the MKP-1 down-regulation and ERK activation . Cell Signal . 2000;12:457–461
- . Angiogenesis in cancer and other diseases . Nature . 2000;407:249–257
- . Id proteins in development, cell cycle and cancer . Trends Cell Biol . 2003;13:410–418
- Impaired Fas response and autoimmunity in Pten+/− mice . Science . 1999;285:2122–2125
- Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse . Nat Genet . 2001;27:222–224
- . Cancer without disease . Nature . 2004;427:787
- High serum endostatin levels in Down syndrome (Implications for improved treatment and prevention of solid tumours) . Eur J Hum Genet . 2001;9:811–814
- A polymorphism in endostatin, an angiogenesis inhibitor, predisposes for the development of prostatic adenocarcinoma . Cancer Res . 2001;61:7375–7378
PII: S0360-3016(05)00442-6
doi: 10.1016/j.ijrobp.2005.03.024
© 2006 Elsevier Inc. All rights reserved.
« Previous
Next »
International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 1
, Pages 26-32
, 1 January 2006
