International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 1 , Pages 57-62 , 1 January 2006

Intensity-modulated radiation therapy (IMRT) for nasopharynx cancer: Update of the Memorial Sloan-Kettering experience

Presented in part at the 41st Annual Meeting of the American Society of Clinical Oncology (ASCO), May 14, 2005, Orlando, Florida.

  • Suzanne L. Wolden, M.D.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY USA
    • Corresponding Author InformationReprint requests to: Suzanne L. Wolden, M.D., Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., SM07, NY, NY 10021. Tel: (212) 639-5148
    • ,
  • William C. Chen, B.S.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY USA
    • ,
  • David G. Pfister, M.D.

      Affiliations

    • Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY USA
    • ,
  • Dennis H. Kraus, M.D.

      Affiliations

    • Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY
    • ,
  • Sean L. Berry, B.S.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY USA
    • ,
  • Michael J. Zelefsky, M.D.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY USA

Received 24 February 2005 ,Revised 24 March 2005 ,Accepted 24 March 2005.

References 

  1. Hoppe RT , Goffinet DR , Bagshaw MA . Carcinoma of the nasopharynx (Eighteen years’ experience with megavoltage radiation therapy) . Cancer . 1976;37:2605–2612
  2. Vikram B , Mishra UB , Strong EW , et al.   Patterns of failure in carcinoma of the nasopharynx: I. Failure at the primary site . Int J Radiat Oncol Biol Phys . 1985;11:1455–1459
  3. Perez CA , Devineni VR , Marcial-Vega V , et al.   Carcinoma of the nasopharynx (Factors affecting prognosis) . Int J Radiat Oncol Biol Phys . 1992;23:271–280
  4. Sanguineti G , Geara FB , Garden AS , et al.   Carcinoma of the nasopharynx treated by radiotherapy alone (Determinants of local and regional control) . Int J Radiat Oncol Biol Phys . 1997;37:985–996
  5. Lee AW , Law SC , Foo W , et al.   Nasopharyngeal carcinoma (Local control by megavoltage irradiation) . Br J Radiol . 1993;66:528–536
  6. Wolden SL , Zelefsky MJ , Hunt MA , et al.   Failure of a 3D conformal boost to improve radiotherapy for nasopharyngeal carcinoma . Int J Radiat Oncol Biol Phys . 2001;49:1229–1234
  7. Wolden SL , Pfister DG , Zelefsky MJ , et al.   Intensity modulated radiation therapy improves locoregional control for nasopharyngeal carcinoma . [Abstract] J Clin Oncol . 2002;20:956
  8. Fleming ID , Cooper J , Henson DE , et al.   In: AJCC cancer staging manual . 5th ed.. Philadelphia: Lippincott-Raven Publishers; 1997;p. 31–39
  9. Hunt MA , Zelefsky MJ , Wolden SL , et al.   Treatment planning and delivery of intensity modulated radiation therapy for primary nasopharynx cancer . Int J Radiat Oncol Biol Phys . 2001;49:623–632
  10. Wolden SL , Zelefsky MJ , Kraus DH , et al.   Accelerated concomitant boost radiotherapy and chemotherapy for advanced nasopharyngeal carcinoma . J Clin Oncol . 2001;19:1105–1110
  11. Fu KK , Pajak TF , Trotti A , et al.   A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas (First report of RTOG 9003) . Int J Radiat Oncol Biol Phys . 2000;48:7–16
  12. Ang K , Peters LJ , Weber RS , et al.   Concomitant boost radiotherapy schedules in the treatment of carcinoma of the oropharynx and nasopharynx . Int J Radiat Oncol Biol Phys . 1990;19:1339–1345
  13. Al-Sarraf M , LeBlanc M , Giri PG , et al.   Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer (Phase III randomized Intergroup study 0099) . J Clin Oncol . 1998;16:1310–1317
  14. Williams J , Chen Y , Rubin P , et al.   The biological basis of a comprehensive grading system for adverse effects of cancer treatment . Semin Radiat Oncol . 2003;13:182–188
  15. Kaplan EL , Meier P . Nonparametric estimation from incomplete observations . J Am Stat Assoc . 1958;53:457–481
  16. Mantel N . Evaluation of survival data and two rank order statistics arising in its consideration . Cancer Chemo Reports . 1974;50:163–170
  17. International histological classification of tumors. Histological typing of upper respiratory tract tumors . World Health Organization . 1978;19:32
  18. Xia P , Fu KK , Wong GW , et al.   Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma . Int J Radiat Oncol Biol Phys . 2000;48:329–337
  19. Lee N , Xia P , Quivey JM , et al.   Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma (An update of the UCSF experience) . Int J Radiat Oncol Biol Phys . 2002;53:12–22
  20. Chong Z . Improved local control with intensity modulated radiation therapy in patients with nasopharyngeal carcinoma . [Abstract] Int J Radiat Oncol Biol Phys . 2004;60:317
  21. Bucci M , Xia P , Lee N , et al.   Intensity modulated radiation therapy for carcinoma of the nasopharynx (An update of the UCSF experience) . [Abstract] Int J Radiat Oncol Biol Phys . 2004;60:317–318
  22. Butler EB , Teh BS , Grant WH , et al.   SMART (simultaneous modulated accelerated radiation therapy) boost (A new accelerated fractionation schedule for the treatment of head and neck cancer with intensity modulated radiotherapy) . Int J Radiat Oncol Biol Phys . 1999;45:21–32
  23. Lauve A , Morris M , Schmidt-Ullrich R , et al.   Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas (II-clinical results) . Int J Radiat Oncol Biol Phys . 2004;60:374–387
  24. Chao KS , Bosch WR , Mutic S , et al.   A prospective study on tumor hypoxia kinetics to implement hypoxic imaging-guided IMRT . [Abstract] Int J Radiat Oncol Biol Phys . 2001;51:83
  25. Faivre S , François J , Armand JP . Optimal management of nasopharyngeal carcinoma . Curr Opin Oncol . 2004;16:231–235
  26. Ho WK , Wei WI , Kwong DL , et al.   Long-term sensorineural hearing deficit following radiotherapy in patients suffering from nasopharyngeal carcinoma (A prospective study) . Head Neck . 1999;21:547–553

 This work was supported by a grant from the Tomorrow Foundation, Inc.

PII: S0360-3016(05)00592-4

doi: 10.1016/j.ijrobp.2005.03.057

International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 1 , Pages 57-62 , 1 January 2006

Article Tools

* Image Usage & Resolution