International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 2 , Pages 392-395 , 1 February 2006

Tetracaine oral gel in patients treated with radiotherapy for head-and-neck cancer: Final results of a phase II study

  • Daniela Alterio, M.D.

      Affiliations

    • Department of Radiation Therapy of the European Institute of Oncology, Milan, Italy
    • Corresponding Author InformationReprint requests to: Daniela Alterio, M.D., European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy. Tel: (+39) 02-57489037; Fax: (+39) 02-57489036
    • ,
  • Barbara Alicja Jereczek-Fossa, M.D., Ph.D.

      Affiliations

    • Department of Radiation Therapy of the European Institute of Oncology, Milan, Italy
    • ,
  • Gabriele Fulvio Zuccotti, Pharm.D.

      Affiliations

    • Pharmacy Service of the European Institute of Oncology, Milan, Italy
    • ,
  • Maria Elena Leon, Sc.D.

      Affiliations

    • Division of Epidemiology of the European Institute of Oncology, Milan, Italy
    • ,
  • Emanuela Omodeo Sale, Pharm.D.

      Affiliations

    • Pharmacy Service of the European Institute of Oncology, Milan, Italy
    • ,
  • Marcella Pasetti, M.D.

      Affiliations

    • Department of Radiation Therapy of the European Institute of Oncology, Milan, Italy
    • ,
  • Tiziana Modena, Pharm.D.

      Affiliations

    • Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy
    • ,
  • Paola Perugini (Prof.)

      Affiliations

    • Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy
    • ,
  • Luigi Mariani, M.D., Ph.D.

      Affiliations

    • Division of Epidemiology of the European Institute of Oncology, Milan, Italy
    • Istituto Nazionale Tumori, Milan, Italy
    • ,
  • Roberto Orecchia, Prof.

      Affiliations

    • Department of Radiation Therapy of the European Institute of Oncology, Milan, Italy
    • Faculty of Medicine, University of Milan, Milan, Italy

Received 12 May 2005 ,Revised 7 July 2005 ,Accepted 7 July 2005.

References 

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  2. Cox JD , Stets J , Pajak TF . Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) . Int J Radiat Oncol Biol Phys . 1995;31:1341–1346
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  5. Dodd MJ , Dibble SL , Miaskowski C , et al.   Randomized clinical trial of the effectiveness of 3 commonly used mouthwashes to treat chemotherapy-induced mucositis . Oral Surg Oral Med Oral Pathol Oral Radiol Endod . 2000;90:39–476
  6. LeVeque FG , Parzuchowski JB , Farinacci GC . Clinical evaluation of MGI 209, an anesthetic, film-forming agent for relief from painful oral ulcers associated with chemotherapy . J Clin Oncol . 1992;10:1963–1968
  7. Redding SW , Haveman CW . Treating the discomfort of oral ulceration resulting from cancer chemotherapy . Compend Contin Educ Dent . 1999;20:389–392 394
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  9. Cerchietti LC , Navigante AH , Bonomi MR , et al.   Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma . Cancer . 2002;95:2230–2236
  10. Cerchietti LC , Navigante AH , Korte MW , et al.   Potential utility of the peripheral analgesic properties of morphine in stomatitis-related pain (A pilot study) . Pain . 2003;105(1–2):265–273
  11. Slatkin NE , Rhiner M . Topical ketamine in the treatment of mucositis pain . Pain Med . 2003;4:298–303
  12. Turhal NS , Erdal S , Karacay S . Efficacy of treatment to relieve mucositis-induced discomfort . Support Care Cancer . 2000;8:55–58
  13. Epstein JB , Truelove EL , Oien H , et al.   Oral topical doxepin rinse (Analgesic effect in patients with oral mucosal pain due to cancer or cancer therapy) . Oral Oncol . 2001;37:632–637

PII: S0360-3016(05)01173-9

doi: 10.1016/j.ijrobp.2005.07.301

International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 2 , Pages 392-395 , 1 February 2006

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