International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 2 , Pages 374-381 , 1 February 2006

Preliminary results of radiation dose escalation for locally advanced nasopharyngeal carcinoma

  • Dora L.W. Kwong (F.R.C.R.)

      Affiliations

    • Department of Clinical Oncology, the University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    • Corresponding Author InformationReprint requests to: Dora L.W. Kwong, F.R.C.R., Department of Clinical Oncology, The University of Hong Kong, 1/F, Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong. Tel: (+852) 28554521; Fax: (+852) 28726426
    • ,
  • Jonathan S.T. Sham (F.R.C.R.)

      Affiliations

    • Department of Clinical Oncology, the University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    • ,
  • Lucullus H.T. Leung, Ph.D.

      Affiliations

    • Department of Clinical Oncology, the University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    • ,
  • Ashley C.K. Cheng (F.R.C.R.)

      Affiliations

    • Department of Clinical Oncology, the University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    • ,
  • W.M. Ng (F.R.C.S.)

      Affiliations

    • Department of Surgery, the University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    • ,
  • Philip W.K. Kwong (F.R.C.R.)

      Affiliations

    • Department of Clinical Oncology, the University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    • ,
  • W.M. Lui (F.R.C.S.)

      Affiliations

    • Department of Surgery, the University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    • ,
  • C.C. Yau (F.R.C.R.)

      Affiliations

    • Department of Clinical Oncology, the University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    • ,
  • P.M. Wu, Ph.D.

      Affiliations

    • Department of Clinical Oncology, the University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    • ,
  • William Wei (F.R.C.S.)

      Affiliations

    • Department of Surgery, the University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    • ,
  • Gordon Au (F.R.C.R.)

      Affiliations

    • Department of Clinical Oncology, the University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong

Received 8 June 2005 ,Revised 14 July 2005 ,Accepted 17 July 2005.

References 

  1. Teo P , Yu P , Lee WY , et al.   Significant prognosticators after primary radiotherapy in non-disseminated nasopharyngeal carcinoma evaluated by computer tomography . Int J Radiat Oncol Biol Phys . 1996;36:291–304
  2. Sanguineti G , Geara F , Garden A , et al.   Carcinoma of the nasopharynx treated by radiotherapy alone (Determinants of local and regional control) . Int J Radiat Oncol Biol Phys . 1997;37:985–996
  3. Lee AW , Au JS , Teo PM , et al.   Staging of nasopharyngeal carcinoma (Suggestions for improving the current UICC/AJCC staging system) . Clin Oncol . 2004;16:269–276
  4. Kwong D , Sham J , Choy D . The effect of loco-regional control on distant metastatic dissemination in carcinoma of the nasopharynx (An analysis of 1301 patients) . Int J Radiat Oncol Biol Phys . 1994;30:1029–1036
  5. Lee AW , Sze WM , Au JS , et al.   Treatment results for nasopharyngeal carcinoma in the modern era (The Hong Kong experience) . Int J Radiat Oncol Biol Phys . 2005;61:1107–1116
  6. Marks JE , Bedwinek JM , Lee F , et al.   Dose-response analysis for nasopharyngeal carcinoma (An historical perspective) . Cancer . 1982;50:1042–1050
  7. Teo PM , Leung SF , Lee WY , et al.   Intracavitary brachytherapy significantly enhances local control of early T-stage nasopharyngeal carcinoma (The existence of a dose-tumor-control relationship above conventional tumoricidal dose) . Int J Radiat Oncol Biol Phys . 2000;46:445–458
  8. Le QT , Tate D , Koong A , et al.   Improved local control with stereotactic radiosurgical boost in patients with nasopharyngeal carcinoma . Int J Radiat Oncol Biol Phys . 2003;56:1046–1054
  9. Wolden SL , Zelefsky MJ , Hunt MA , et al.   Failure of a 3D conformal boost to improve radiotherapy for nasopharyngeal carcinoma . Int J Radiat Oncol Biol Phys . 2001;49:1229–1234
  10. Tate DJ , Adler JR , Chang SD , et al.   Stereotactic radiosurgical boost following radiotherapy in primary nasopharyngeal carcinoma (Impact on local control) . Int J Radiat Oncol Biol Phys . 1999;45:915–921
  11. Levendag PC , Lagerwaard FJ , de Pan C , et al.   High-dose, high-precision treatment options for boosting cancer of the nasopharynx . Radiother Oncol . 2002;63:67–74
  12. Jen YM , Lin YS , Su WF , et al.   Dose escalation using twice-daily radiotherapy for nasopharyngeal carcinoma (Does heavier dosing result in a happier ending?) . Int J Radiat Oncol Biol Phys . 2002;54:14–22
  13. Teo PM , Leung SF , Chan AT , et al.   Final report of a randomized trial on altered-fractionated radiotherapy in nasopharyngeal carcinoma prematurely terminated by significant increase in neurologic complications . Int J Radiat Oncol Biol Phys . 2000;48:1311–1322
  14. Lee AW , Sze WM , Yau TK , et al.   Retrospective analysis on treating nasopharyngeal carcinoma with accelerated fractionation (6 fractions per week) in comparison with conventional fractionation (5 fractions per week) (Report on 3-year tumor control and normal tissue toxicity) . Radiother Oncol . 2001;58:121–130
  15. Al-Sarraf M , LeBlanc M , Giri PG , et al.   Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer (Phase III randomized Intergroup study 0099) . J Clin Oncol . 1998;16:1310–1317
  16. Lin JC , Jan JS , Hsu CY , et al.   Phase III study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma (Positive effect on overall and progression-free survival) . J Clin Oncol . 2003;21:631–637
  17. Chan AT , Leung SF , Ngan RK , et al.   Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma . J Natl Cancer Inst . 2005;97:536–539
  18. Kwong DL , Sham JS , Au GK , et al.   Concurrent and adjuvant chemotherapy for nasopharyngeal carcinoma (A factorial study) . J Clin Oncol . 2004;22:2643–2653
  19. Butler EB , Teh BS , Grant WH , et al.   SMART (simultaneous modulated accelerated radiation therapy) boost (A new accelerated fractionation schedule for the treatment of head and neck cancer with intensity modulated radiotherapy) . Int J Radiat Oncol Biol Phys . 1999;45:21–32
  20. Gregoire V , Coche E , Cosnard G , et al.   Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy (Proposal for standardizing terminology and procedure based on the surgical experience) . Radiother Oncol . 2000;56:135–150
  21. Curran B . Conformal radiation therapy using a multileaf intensity modulating collimator . In:  Sternick ES editors. The theory and practice of internsity modulated radiation therapy. Proceedings of the 1st NOMOS IMRT workshop, Durango, Colorado . Madison: Advanced Medical Publishing; 1997;p. 75–90
  22. Lauve A , Morris M , Schmidt-Ullrich R , et al.   Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas (II–clinical results) . Int J Radiat Oncol Biol Phys . 2004;60:374–387
  23. Chao KS , Low DA , Perez CA , et al.   Intensity-modulated radiation therapy in head and neck cancers (The Mallinckrodt experience) . Int J Cancer . 2000;90:92–103
  24. Lee N , Xia P , Fischbein NJ , et al.   Intensity-modulated radiation therapy for head-and-neck cancer (The UCSF experience focusing on target volume delineation) . Int J Radiat Oncol Biol Phys . 2003;57:49–60
  25. Kam MK , Teo PM , Chau RM , et al.   Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy (The Hong Kong experience) . Int J Radiat Oncol Biol Phys . 2004;60:1440–1450
  26. Wolden SL , Chen WC , Pfister DG , et al.   Intensity-modulated radiation therapy (IMRT) for nasopharynx cancer (Update of the Memorial Sloan-Kettering experience) . Int J Radiat Oncol Biol Phys . 2005; in press
  27. Cheng KM , Chan CM , Cheung YL , et al.   Endovascular treatment of radiation-induced petrous internal carotid artery aneurysm presenting with acute haemorrhage (A report of two cases) . Acta Neurochir (Wien) . 2001;143:351–355
  28. Ang KK , Peters LJ , Weber RS , et al.   Concomitant boost radiotherapy schedules in the treatment of carcinoma of the oropharynx and nasopharynx . Int J Radiat Oncol Biol Phys . 1990;19:1339–1345
  29. Silverberg GD , Britt RH , Goffinet DR . Radiation-induced carotid artery disease . Cancer . 1978;41:130–137
  30. Murros KE , Toole JF . The effect of radiation on carotid arteries (A review article) . Arch Neurol . 1989;46:449–455

 This study was supported by grants from the University of Hong Kong (CRCG Grant number: 10202651/25065/21600/323/01, 10203969/25065/21600/301/01, 10204855/25065/21600/302/01).

PII: S0360-3016(05)02217-0

doi: 10.1016/j.ijrobp.2005.07.968

International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 2 , Pages 374-381 , 1 February 2006

Article Tools

* Image Usage & Resolution