International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 1 , Pages 3-5 , 1 January 2006

Radiation-enhanced immune response to cancer: Workshop, Anaheim, CA, April 17, 2005

  • Robert M. Sutherland, Ph.D.

      Affiliations

    • Corresponding Author InformationReprint requests to: Robert M. Sutherland, Ph.D., Varian Medical Systems, Varian Biosynergy, 2599 Garcia Ave, Mountain View, CA 94043. Tel: (650) 623-1209; Fax: (650) 623-1297

Received 13 June 2005 ,Revised 10 August 2005 ,Accepted 17 August 2005.

References 

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  2. Demaria S , Ng B , Devitt ML , et al.   Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated . Int J Radiat Oncol Biol Phys . 2004;58:862–870
  3. Chakraborty M , Abrams SI , Coleman CN , et al.   External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing . Cancer Res . 2004;64:4328–4337
  4. Garnett CT , Palena C , Chakarborty M , et al.   Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes . Cancer Res . 2004;64:7985–7994
  5. Demaria S , Kawashima N , Yang AM , et al.   Immune-mediated inhibition of metastases following treatment with local radiation and CTLA-4-blockade in a mouse model of breast cancer . Clin Cancer Res . 2005;11:1–7
  6. Milas L , Mason KA , Ariga H , et al.   CpG oligodeoxynucleotide enhances tumor response to radiation . Cancer Res . 2004;64:5074–5077
  7. Mason KA , Ariga H , Neal R , et al.   Targeting toll-like receptor 9 with CpG oligodeoxynucleotides enhances tumor response to fractionated radiotherapy . Clin Cancer Res . 2005;11:361–369
  8. MacEwen EG , Kurzman ID , Vail DM , et al.   Adjuvant therapy for melanoma in dogs (Clinical trials using surgery, liposome-encapsulated muramyl tripeptide and granulocyte macrophage colony-stimulating factor) . Clin Cancer Res . 1999;5:4249–4258
  9. Kudo-Saito C , Schlom J , Hodge JW . Induction of an antigen cascade by diversified subcutaneous/intratumoral vaccination is associated with antitumor responses . Clin Cancer Res . 2005;11:2416–2426
  10. Lugade AA , Moran JP , Gerber SA , et al.   Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor . J Immunol . 2005;174:7516–7523
  11. Liao YP , Wang CC , Butterfield LH , et al.   Ionizing radiation affects human MART-1 melanoma antigen processing and presentation by dendritic cells . J Immunol . 2004;173:2462–2469

 Workshop participants: Silvia Formenti (New York University), Chandan Guha (Einstein/Montefiore), Jeffrey Schlom (National Cancer Institute [NCI]), William McBride (University of California-Los Angeles), Howard Streicher (NCI), Luka Milas (M. D. Anderson Cancer Center), Douglas Thamm (Colorado State University [CSU]), Richard Morse (Varian Medical Systems), David Vail (CSU), Robert Sutherland (Varian Biosynergy), and Dennis Panical (Therion Biologics).

PII: S0360-3016(05)02581-2

doi: 10.1016/j.ijrobp.2005.08.036

International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 1 , Pages 3-5 , 1 January 2006