International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 4 , Pages 1018-1022 , 15 March 2006

Conservation treatment of the eye: Conformal proton reirradiation for recurrent uveal melanoma

Presented as a poster at the Forty-third Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), San Francisco, CA.

  • Laura Marucci, M.D.

      Affiliations

    • Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA
    • Corresponding Author InformationReprint requests to: John E. Munzenrider, M.D., Department of Radiation Oncology, Francis H. Burr Proton Therapy, Massachusetts General Hospital, 30 Fruit St., Boston, MA 02114. Tel: (617) 726-6876; Fax: (617) 724-9532
    • ,
  • Anne M. Lane, M.P.H.

      Affiliations

    • Retina Service, Massachusetts Eye and Ear Infirmary, Boston, MA
    • ,
  • Wenjun Li, M.S.

      Affiliations

    • Biostatistics Unit, New England Medical Center, Boston, MA
    • ,
  • Kathleen M. Egan, Sc.D.

      Affiliations

    • Retina Service, Massachusetts Eye and Ear Infirmary, Boston, MA
    • ,
  • Evangelos S. Gragoudas, M.D.

      Affiliations

    • Retina Service, Massachusetts Eye and Ear Infirmary, Boston, MA
    • ,
  • Judy A. Adams, C.M.D.

      Affiliations

    • Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA
    • ,
  • John M. Collier, Ph.D.

      Affiliations

    • Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA
    • ,
  • John E. Munzenrider, M.D.

      Affiliations

    • Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA

Received 29 October 2003 ,Revised 23 August 2005 ,Accepted 7 September 2005.

References 

  1. Augsburger JJ , Schneider S , Freire J , Brady L . Survival following enucleation versus plaque radiotherapy in statistically matched subgroups of patients with choroidal melanomas (results in patients treated between 1980 and 1987) . Graefes Arch Clin Exp Ophthalmol . 1999;237:558–567
  2. Castro JR , Char DH , Petti PL , et al.   15 years experience with helium ion radiotherapy for uveal melanoma . Int J Radiat Oncol Biol Phys . 1997;39:989–996
  3. Daftari IK , Char DH , Verhey LJ , et al.   Anterior segment sparing to reduce charged particle radiotherapy complications in uveal melanoma . Int J Radiat Oncol Biol Phys . 1997;39:997–1010
  4. Desjardins L , Levy C , d’Hermies F , et al.   Initial results of proton therapy in choroidal melanoma at the d’Orsey center for proton therapy (The first 464 patients) . Cancer Radiother . 1997;1:222–226
  5. Egger E , Schalenbourg A , Zografos L , et al.   Maximizing local tumor control and survival after proton beam radiotherapy of uveal melanoma . Int J Radiat Oncol Biol Phys . 2001;151:138–147
  6. Gragoudas ES , Goitein M , Koehler AM , et al.   Proton irradiation of small choroidal malignant melanomas . Am J Ophthalmol . 1977;83:655–673
  7. Gragoudas ES , Seddon JM , Egan KM , et al.   Long-term results of proton beam irradiated uveal melanomas . Arch Ophthalmol . 1987;94:349–353
  8. Miller DW . A review of proton beam radiotherapy . Med Phys . 1995;22:1943–1954
  9. Wilson MW , Hungerford JL . Comparison of plaque and proton beam radiation therapy for treatment of choroidal melanoma . Ophthalmology . 1999;106:1579–1587
  10. Gunduz K , Shields CL , Shields JA , et al.   Radiation complications and tumor control after plaque radiotherapy of choroidal melanomas with macular involvement . Am J Ophthalmol . 1999;127:579–589
  11. Lommatzsch PK , Werschnik C , Schuster E . Long-term follow-up of Ru-106/Rh-106 brachytherapy for posterior uveal melanoma . Graefes Arch Clin Exp Ophthalmol . 2000;238:129–137
  12. Rotman M , Long RS , Packer S . Radiation therapy of uveal melanomas . Trans Ophthalmol Soc UK . 1977;97:431–435
  13. Seddon JM , Gragoudas ES , Albert DM , et al.   Comparison of survival rates for patients with uveal melanoma after treatment with proton beam irradiation or enucleation . Am J Ophthalmol . 1985;99:290
  14. Seddon JM , Gragoudas ES , Egan KM , et al.   Relative survival rates after alternative therapies for uveal melanoma . Ophthalmology . 1990;97:769–777
  15. Goitein M , Miller T . Planning proton therapy of the eye . Med Phys . 1983;10:275–283
  16. Gragoudas ES , Goitein M , Verhey LJ , et al.   Proton beam irradiation, an alternative to enucleation for intraocular melanoma . Ophthalmology . 1980;87:571–581
  17. Egan KM , Gragoudas ES , Seddon JM , et al.   The risk of enucleation after proton beam irradiation of uveal melanoma . Ophthalmology . 1989;96:1377–1383
  18. Gragoudas ES , Seddon JM , Polivogianis LL , et al.   Prognostic factors for metastasis following proton beam irradiation of uveal melanomas . Ophthalmology . 1986;93:680
  19. Gragoudas ES , Seddon JM , Egan KM , et al.   Metastasis from uveal melanoma after proton beam irradiation . Ophthalmology . 2003;95:992–999
  20. Egan KM , Ryan LM , Gragoudas ES . Survival implications of enucleation after definitive radiotherapy for choroidal melanoma, an example of regression on time-dependent covariates . Arch Ophthalmol . 1998;116:366–370
  21. Seddon JM , Gragoudas ES , Polivogianis LL , et al.   Visual outcome after proton beam irradiation of uveal melanoma . Ophthalmology . 1986;93:674

 Laura Marucci, M.D., is currently at the Department of Radiation Oncology, Research Institute Regina Elena, Rome, Italy.

PII: S0360-3016(05)02703-3

doi: 10.1016/j.ijrobp.2005.09.035

International Journal of Radiation Oncology * Biology * Physics
Volume 64, Issue 4 , Pages 1018-1022 , 15 March 2006

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