International Journal of Radiation Oncology * Biology * Physics
Volume 65, Issue 1 , Pages 25-32 , 1 May 2006

Prospective multicenter study of combined treatment with chemotherapy and radiotherapy in breast cancer women with the rare clinical scenario of ipsilateral supraclavicular node recurrence without distant metastases

  • Stefano Pergolizzi, M.D.

      Affiliations

    • Department of Radiological Science, University of Messina, Messina, Italy
    • Operative Unit of Radiation Oncology, Presidio Ospedaliero “S. Vincenzo,” Taormina, Italy
    • Corresponding Author InformationReprint requests to: Stefano Pergolizzi, M.D., Via Salita Ogliastri 16, 98100 Messina, Italy. Tel: (+39) 90-2212930; Fax: (+39) 90-2213192
  • ,
  • Vincenzo Adamo, M.D.

      Affiliations

    • Department of Medical Oncology, University of Messina, Messina, Italy
  • ,
  • Elvio Russi, M.D.

      Affiliations

    • Department of Radiation Oncology, Azienda “S. Croce e Carle,” Cuneo, Italy
  • ,
  • Anna Santacaterina, M.D.

      Affiliations

    • Operative Unit of Radiation Oncology, Presidio Ospedaliero “S. Vincenzo,” Taormina, Italy
  • ,
  • Roberto Maisano, M.D.

      Affiliations

    • Department of Medical Oncology, Ospedali Riuniti, Reggio Calabria, Italy
  • ,
  • Gianmauro Numico, M.D.

      Affiliations

    • Department of Medical Oncology, Azienda “S. Croce e Carle,” Cuneo, Italy
  • ,
  • Carmela Palazzolo, M.D.

      Affiliations

    • Operative Unit of Radiation Oncology, Presidio Ospedaliero “S. Vincenzo,” Taormina, Italy
  • ,
  • Francesco Ferraù, M.D.

      Affiliations

    • Department of Medical Oncology, Presidio Ospedaliero “S. Vincenzo,” Taormina, Italy
  • ,
  • Nicola Settineri, Ph.D.

      Affiliations

    • Department of Radiological Science, University of Messina, Messina, Italy
  • ,
  • Giuseppe Altavilla, M.D.

      Affiliations

    • Department of Medical Oncology, University of Messina, Messina, Italy
  • ,
  • Andrea Girlando, M.D.

      Affiliations

    • Department of Radiation Oncology, Centro Catanese di Oncologia, Catania, Italy
  • ,
  • Pietro Spadaro, M.D.

      Affiliations

    • Operative Unit of Medical Oncology, Casa di Cura Villa Salus, Messina, Italy
  • ,
  • Stefano Cascinu, M.D.

      Affiliations

    • Department of Medical Oncolgy, University of Ancona, Ancona, Italy

Received 6 September 2005 ,Revised 16 November 2005 ,Accepted 17 November 2005.

References 

  1. Recht A , Pierce SM , Abner A , et al.   Regional nodal failure after conservative surgery and radiotherapy for early-stage breast carcinoma . J Clin Oncol . 1991;9:988–996
  2. Fentiman IS , Lavelle MA , Caplan D , et al.   The significance of supraclavicular fossa node recurrence after radical mastectomy . Cancer . 1986;57:908–910
  3. Kiricuta IC , Willner J , Kolbl O , et al.   The prognostic significance of the supraclavicular lymph node metastases in breast cancer patients . Int J Radiat Oncol Biol Phys . 1994;28:387–393
  4. van der Sangen MJC , Coebergh J-WW , Roumen RMH , et al.   Detection, treatment, and outcome of isolated supraclavicular recurrence in 42 patients with invasive breast carcinoma . Cancer . 2003;98:11–17
  5. Schmoor C , Sauerbrei W , Bastert G , et al.   Role of isolated locoregional recurrence of breast cancer (Results of four prospective studies) . J Clin Oncol . 2000;18:1696–1708
  6. Haylock BJ , Coppin CML , Jackson J , et al.   Locoregional first recurrence after mastectomy (Prospective cohort studies with and without immediate chemotherapy) . Int J Radiat Oncol Biol Phys . 2000;46:355–362
  7. Recht A , Gray R , Davidson NE , et al.   Locoregional failure 10 years after mastectomy and adjuvant chemotherapy with or without tamoxifen without irradiation (Experience of the Eastern Cooperative Oncology Group) . J Clin Oncol . 1999;17:1689–1700
  8. Debois JM . The significance of a supraclavicular node metastasis in patients with breast cancer. A literature review . Strahlenther Onkol . 1997;173:1–12
  9. Hermanek P , Sobin LH . TNM classification of malignant tumours. International Union Against Cancer . 4th ed.. New York: Springer; 1987;
  10. Brito RA , Valero V , Buzdar AU , et al.   Long-term results of combined-modality therapy for locally advanced breast cancer with ipsilateral supraclavicular metastases (The University of Texas M.D. Anderson Cancer Center experience) . J Clin Oncol . 2001;19:628–633
  11. Singletary SE , Allred C , Ashley P , et al.   Revision of the American Joint Committee on Cancer staging system for breast cancer . J Clin Oncol . 2002;20:3628–3636
  12. Clemons M , Hamilton T , Mansi J , et al.   Management of recurrent locoregional breast cancer (Oncologist survey) . Breast . 2003;12:328–337
  13. Pergolizzi S , Settineri N , Santacaterina A , et al.   Ipsilateral supraclavicular lymph nodes metastases from breast cancer as only site of disseminated disease. Chemotherapy alone vs. induction chemotherapy to radical radiation therapy . Ann Oncol . 2001;12:1091–1095
  14. Abraham R , Nagy T , Goss PE , et al.   High dose chemotherapy and autologous blood stem cell support in women with breast carcinoma and isolated supraclavicular lymph node metastases . Cancer . 2000;88:790–795
  15. Pergolizzi S , Settineri N , Russi EG , et al.   Supraclavicular lymph node metastases from breast cancer as only site of metastatic disease. Has radiotherapy any role? . Anticancer Res . 1997;17:2303–2308
  16. Halverson KJ , Perez CA , Kuske RR , et al.   Locoregional recurrence of breast cancer (A retrospective comparison of irradiation alone versus irradiation and systemic therapy) . Am J Clin Oncol . 1992;15:93–101
  17. Janjan NA , McNeese MD , Buzdar AU . Loco-regional recurrent breast cancer treated with radiation or a combination of radiation and chemotherapy . Int J Radiat Oncol Biol Phys . 1985;11:152–153
  18. Schuck A , Konemann S , Matthees B , et al.   Radiotherapy in the treatment of locoregional relapses of breast cancer . Br J Radiol . 2002;75:663–669
  19. Olivotto IA , Chua B , Allan SJ , et al.   Long-term survival of patients with supraclavicular metastases at diagnosis of breast cancer . J Clin Oncol . 2003;21:851–854
  20. Ampil FL , Caldito G , Li BD , et al.   Supraclavicular nodal relapse of breast cancer (Prevalence, palliation, and prognosis) . Eur J Gynaecol Oncol . 2003;24:233–235
  21. Clemons M , Hamilton T , Goss P . Does treatment at the time of locoregional failure of breast cancer alter prognosis? . Cancer Treat Rev . 2001;27:83–97
  22. Goldhirsch A, Glick JH, Meeting highlights (International consensus panel on the treatment of primary breast cancer) . J Clin Oncol . 2001;19:3817–3827

PII: S0360-3016(05)02972-X

doi: 10.1016/j.ijrobp.2005.11.010

International Journal of Radiation Oncology * Biology * Physics
Volume 65, Issue 1 , Pages 25-32 , 1 May 2006