International Journal of Radiation Oncology * Biology * Physics
Volume 65, Issue 5 , Pages 1300-1306 , 1 August 2006

Improvement of survival after addition of induction chemotherapy to radiotherapy in patients with early-stage nasopharyngeal carcinoma: Subgroup analysis of two Phase III trials

Presented in part at the Thirteenth European Cancer Congress, Paris, France, November 1, 2005.

  • Daniel T.T. Chua, F.R.C.R.

      Affiliations

    • Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    • Corresponding Author InformationReprint requests to: Daniel T.T. Chua, F.R.C.R., Department of Clinical Oncology, PB-115, Queen Mary Hospital, Pokfulam, Hong Kong. Tel: (+852) 2855-4223; Fax: (+852) 2872-6426
    • ,
  • Jun Ma, M.D.

      Affiliations

    • Department of Radiation Oncology, Cancer Center and State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, Guangzhou, China
    • ,
  • Jonathan S.T. Sham, M.D.

      Affiliations

    • Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    • ,
  • Hai-Qiang Mai, M.D.

      Affiliations

    • Department of Nasopharyngeal Carcinoma, Cancer Center and State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, Guangzhou, China
    • ,
  • Damon T.K. Choy, F.R.C.R.

      Affiliations

    • Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    • ,
  • Ming-Huang Hong, M.D.

      Affiliations

    • Department of Nasopharyngeal Carcinoma, Cancer Center and State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, Guangzhou, China
    • ,
  • Tai-Xiang Lu, M.D.

      Affiliations

    • Department of Radiation Oncology, Cancer Center and State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, Guangzhou, China
    • ,
  • Gordon K.H. Au, F.R.C.R.

      Affiliations

    • Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    • ,
  • Hua-Qing Min, M.D.

      Affiliations

    • Department of Nasopharyngeal Carcinoma, Cancer Center and State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, Guangzhou, China

Received 23 November 2005 ,Revised 20 February 2006 ,Accepted 21 February 2006.

References 

  1. Al-Sarraf M , LeBlanc M , Giri PG , et al.   Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer (Phase III randomized Intergroup study 0099) . J Clin Oncol . 1998;16:1310–1317
  2. Lin JC , Jan JS , Hsu CY , et al.   Phase III study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma (Positive effect on overall and progression-free survival) . J Clin Oncol . 2003;21:631–637
  3. Chan AT , Leung SF , Ngan RK , et al.   Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma . J Natl Cancer Inst . 2005;97:536–539
  4. Wee J , Tan EH , Tai BC , et al.   Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union Against Cancer Stage III and IV nasopharyngeal cancer of the endemic variety . J Clin Oncol . 2005;23:6730–6738
  5. International Nasopharynx Cancer Study Group . VUMCA I trial: Preliminary results of a randomized trial comparing neoadjuvant chemotherapy (cisplatin, epirubicin, bleomycin) plus radiotherapy vs. radiotherapy alone in Stage IV (≥N2, M0) undifferentiated nasopharyngeal carcinoma: A positive effect on progression-free survival . Int J Radiat Oncol Biol Phys . 1996;35:463–469
  6. Chua DTT , Sham JST , Choy D , et al.   Preliminary report of the Asian-Oceanian Clinical Oncology Association randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with locoregionally advanced nasopharyngeal carcinoma . Cancer . 1998;83:2270–2283
  7. Ma J , Mai H , Hong M , et al.   Results of a prospective randomized trial comparing neoadjuvant chemotherapy plus radiotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma . J Clin Oncol . 2001;19:1350–1357
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  10. Chua DT , Ma J , Sham JS , et al.   Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma (A pooled data analysis of two phase III trials) . J Clin Oncol . 2005;23:1118–1124
  11. American Joint Committee on Cancer . Manual for staging of cancer . 5th ed.. Philadelphia: JB Lippincott; 1997;
  12. Chua DT , Sham JS , Wei WI , et al.   The predictive value of the 1997 American Joint Committee on Cancer Stage Classification in determining failure patterns in nasopharyngeal carcinoma . Cancer . 2001;92:2845–2855
  13. Chan AT , Teo PM , Leung TW , et al.   A prospective randomized study of chemotherapy adjunctive to definitive radiotherapy in advanced nasopharyngeal carcinoma . Int J Radiat Oncol Biol Phys . 1995;33:569–577
  14. Lee AW , Sze WM , Au JS , et al.   Treatment results for nasopharyngeal carcinoma in the modern era (The Hong Kong experience) . Int J Radiat Oncol Biol Phys . 2005;61:1107–1116
  15. Lee AW , Poon YF , Foo W , et al.   Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976–1985 (Overall survival and patterns of failure) . Int J Radiat Oncol Biol Phys . 1992;23:261–270
  16. Chua DT , Sham JS , Kwong D , et al.   Treatment outcome after radiotherapy alone for patients with stage I-II nasopharyngeal carcinoma . Cancer . 2003;98:74–80
  17. Leung TW , Tung SY , Sze WK , et al.   Treatment results of 1070 patients with nasopharyngeal carcinoma (An analysis of survival and failure patterns) . Head Neck . 2005;27:555–565
  18. Lee AW , Lau WH , Tung SY , et al.   Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma (NPC-9901 trial by the Hong Kong Nasopharyngeal Cancer Study Group) . J Clin Oncol . 2005;23:6966–6975
  19. Cheng SH , Tsai SY , Yen KL , et al.   Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma . J Clin Oncol . 2000;18:2040–2045
  20. Leung SF , Chan ATC , Zee B , et al.   Pretherapy quantitative measurement of circulating Epstein-Barr virus DNA is predictive of posttherapy distant failure in patients with early-stage nasopharyngeal carcinoma of undifferentiated type . Cancer . 2003;98:288–291

 Supported in part by a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (HKU 7237/01M).

PII: S0360-3016(06)00374-9

doi: 10.1016/j.ijrobp.2006.02.016

International Journal of Radiation Oncology * Biology * Physics
Volume 65, Issue 5 , Pages 1300-1306 , 1 August 2006

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