International Journal of Radiation Oncology * Biology * Physics
Volume 65, Issue 5 , Pages 1345-1352 , 1 August 2006

The impact of young age on locoregional recurrence after doxorubicin-based breast conservation therapy in patients 40 years old or younger: How young is “young”?

Presented at the Forty-fifth Annual Meeting of the American Society of Therapeutic Radiology and Oncology (ASTRO), Salt Lake City, UT, October 19–23, 2004.

  • Julia L. Oh, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    • Corresponding Author InformationReprint requests to: Julia L. Oh, M.D., Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1202, Houston, TX 77030. Tel: (713) 563-2300; Fax: (713) 563-6940
  • ,
  • Mark Bonnen, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
  • ,
  • Elesyia D. Outlaw, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
  • ,
  • Naomi R. Schechter, M.D.

      Affiliations

    • Department of Radiation Oncology, University of California–San Francisco Mt. Zion Comprehensive Cancer Center, San Francisco, CA
  • ,
  • George H. Perkins, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
  • ,
  • Eric A. Strom, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
  • ,
  • Gildy Babiera, M.D.

      Affiliations

    • Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
  • ,
  • Mary Jane Oswald, B.S.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
  • ,
  • Pamela K. Allen, Ph.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
  • ,
  • Howard D. Thames, Ph.D.

      Affiliations

    • Department of Biostatistics and Applied Mathematics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
  • ,
  • Thomas A. Buchholz, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

Received 22 August 2005 ,Revised 21 March 2006 ,Accepted 21 March 2006.

References 

  1. American Cancer Society . Breast Cancer Facts and Figures, 2003–2004 . In: Surveillance Research . 2003;p. 3
  2. Nixon AJ , Neuberg D , Hayes DF , et al.   Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer . J Clin Oncol . 1994;12:888–894
  3. Albain KS , Allred DC , Clark GM . Breast cancer outcome and predictors of outcome (Are there age differentials?) . J Natl Cancer Inst Monogr . 1994;16:35–42
  4. Colleoni M , Rotmensz N , Robertson C , et al.   Very young women (<35 years) with operable breast cancer (Features of disease at presentation) . Ann Oncol . 2002;13:273–279
  5. Hankey BF , Miller B , Curtis R , et al.   Trends in breast cancer in younger women in contrast to older women . J Natl Cancer Inst Monogr . 1994;16:7–14
  6. Morrow M , Hassett C . Breast cancer in young women (Issues in local therapy) . J Natl Cancer Inst Monogr . 1994;16:79–84
  7. Borger J , Kemperman H , Hart A , et al.   Risk factors in breast-conservation therapy . J Clin Oncol . 1994;12:653–660
  8. Foxcroft LM , Evans EB , Porter AJ . The diagnosis of breast cancer in women younger than 40 . Breast . 2004;13:297–306
  9. Kim SH , Simkovich-Heerdt A , Tran KN , et al.   Women 35 years of age or younger have higher local-regional relapse rates after undergoing breast conservation therapy . J Am Coll Surg . 1988;187:1–8
  10. Elkhuizen PH , van de Vijver MJ , Hermans J , et al.   Local recurrence after breast-conserving therapy for invasive breast cancer (High incidence in young patients and association with poor survival) . Int J Radiat Oncol Biol Phys . 1998;40:859–867
  11. Lawless JF . Statistical models and methods for lifetime data . New York: John Wiley and Sons; 1982;
  12. Zhou P , Recht A . Young age and outcome for women with early-stage invasive breast carcinoma . Cancer . 2004;101:1264–1274
  13. de la Rochefordiere A , Asselain B , Campana F , et al.   Age as prognostic factor in premenopausal breast carcinoma . Lancet . 1993;341:1039–1043
  14. Fisher B , Jeong JH , Anderson S , et al.   Twenty-five year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation . N Engl J Med . 2004;347:567–575
  15. Veronesi U , Salvadori B , Luini A , et al.   Conservative treatment of early breast cancer. Long-term results of 1232 cases treated with quadrantectomy, axillary dissection, and radiotherapy . Ann Surg . 1990;211:250–259
  16. Solin LJ , Fowble B , Schultz DJ , et al.   Age as a prognostic factor for patients treated with definitive irradiation for early stage breast cancer . Int J Radiat Oncol Biol Phys . 1989;16:373–381
  17. Kurtz JM , Jacquemier J , Luini A , et al.   Risk factors for breast recurrence in premenopausal and postmenopausal patients with ductal cancers treated by conservation therapy . Cancer . 1990;65:1867–1878
  18. Matthews RH , McNeese MD , Montague ED , et al.   Prognostic implications of age in breast cancer patients treated with tumorectomy and irradiation or with mastectomy . Int J Radiat Oncol Biol Phys . 1998;12:659–663
  19. Early Breast Cancer Trialists’ Collaborative Group . Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival (An overview of the randomised trials) . Lancet . 2005;365:1687–1717
  20. Nolvadex (Tamoxifen Citrate) brochure by AstraZeneca. Available at: www.astrazeneca-us.com/pi/Nolvadex.pdf.
  21. Goldhirsch A , Gelber RD , Yothers G , et al.   Adjuvant therapy for very young women with breast cancer (Need for tailored treatments) . J Natl Cancer Inst Monogr . 2001;30:44–51
  22. Dellapasqua S , Colleoni M , Gelber R , et al.   Adjuvant endocrine therapy for premenopausal women with early breast cancer . J Clin Oncol . 2005;23:1736–1750

PII: S0360-3016(06)00529-3

doi: 10.1016/j.ijrobp.2006.03.028

International Journal of Radiation Oncology * Biology * Physics
Volume 65, Issue 5 , Pages 1345-1352 , 1 August 2006