International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 3 , Pages 680-686 , 1 November 2006

Planning the breast tumor bed boost: Changes in the excision cavity volume and surgical scar location after breast-conserving surgery and whole-breast irradiation

Presented in part at the 46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), Atlanta, GA, October 3–7, 2004.

  • Kevin S. Oh, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI
  • ,
  • Feng-Ming Kong, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI
  • ,
  • Kent A. Griffith, M.P.H., M.S.

      Affiliations

    • Biostatistics Unit of the University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
  • ,
  • Beth Yanke, C.M.D.

      Affiliations

    • Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI
  • ,
  • Lori J. Pierce, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI
    • Corresponding Author InformationReprint requests to: Lori J. Pierce, M.D., Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109. Tel: (734) 936-7810; Fax: (734) 763-7370

Received 3 February 2006 ,Revised 11 April 2006 ,Accepted 16 April 2006.

References 

  1. Romestaing P , Lehingue Y , Carrie C , et al.   Role of a 10-Gy boost in the conservative treatment of early breast cancer: results of a randomized clinical trial in Lyons, France . J Clin Oncol . 1997;15:963–968
  2. Bartelink H , Horiot JC , Poortmans P , et al.   Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation . N Engl J Med . 2001;345:1378–1387
  3. Pierce LJ , Moughan J , White J . 1998–1999 Patterns of Care Study process study of national practice patterns using breast-conserving surgery and radiotherapy in the management of Stage I–II breast cancer . Int J Radiat Oncol Biol Phys . 2005;62:183–192
  4. Benda RK , Yasuda G , Sethi A , et al.   Breast boost: are we missing the target? . Cancer . 2003;97:905–909
  5. Denham JW , Sillar RW , Clarke D . Boost dosage to the excision site following conservative surgery for breast cancer: it’s easy to miss! . Clin Oncol . 1991;3:257–261
  6. Bedwinek J . Breast-conserving surgery and irradiation: the importance of demarcating the excision cavity with surgical clips . Int J Radiat Oncol Biol Phys . 1993;26:675–679
  7. Harrington KJ , Harrison M , Bayle P , et al.   Surgical clips in planning the electron boost in breast cancer: a qualitative and quantitative evaluation . Int J Radiat Oncol Biol Phys . 1996;34:579
  8. Hunter MA , McFall TA , Hehr KA . Breast-conserving surgery for primary breast cancer: necessity for surgical clips to define the tumor bed for radiation planning . Radiology . 1996;200:281
  9. Machtay M , Lanciano R , Hoffman J , et al.   Inaccuracies in using the lumpectomy scar for planning electron boosts in primary breast carcinoma . Int J Radiat Oncol Biol Phys . 1994;30:43–48
  10. Messer PM , Kirikuta IC , Bratengeier K , et al.   CT planning of boost irradiation in radiotherapy of breast cancer after conservative surgery . Radiother Oncol . 1997;42:239
  11. Regine WF , Ayyangar KM , Komarnickyk LT , et al.   Computer-CT planning of the electron boost in definitive breast irradiation . Int J Radiat Oncol Biol Phys . 1991;20:121–125
  12. In:  Greene FL ,  Page DL ,  Fleming ID , et al. editor. AJCC cancer staging manual . 6th ed. New York: Springer-Verlag; 2002; editors
  13. Debiose DA , Horwitz EM , Martinez AA , et al.   The use of ultrasonography in the localization of the lumpectomy cavity for interstitial brachytherapy of the breast . Int J Radiat Oncol Biol Phys . 1997;38:755
  14. Gilligan D , Hendry JA , Yarnold JR . The use of ultrasound to measure breast thickness to select electron energies for breast boost therapy . Radiother Oncol . 1994;32:265
  15. Leonard C , Harlow CL , Coffin C , et al.   Use of ultrasound to guide radiation boost planning following lumpectomy for carcinoma of the breast . Int J Radiat Oncol Biol Phys . 1993;27:1193–1197
  16. Solin LJ , Danoff BF , Schwartz GF , et al.   A practical technique for the localization of the tumour volume in definitive irradiation of the breast . Int J Radiat Oncol Biol Phys . 1985;11:1215–1220
  17. Vicini FA , Kestin LL , Goldstein NS . Defining the clinical target volume for patients with early-stage breast cancer treated with lumpectomy and accelerated partial breast irradiation: a pathologic analysis . Int J Radiat Oncol Biol Phys . 2004;60:722–730
  18. Benda RK , Mendenhall NP , Lind DS , et al.   Breast-conserving therapy (BCT) for early-stage breast cancer . J Surg Oncol . 2004;85:14–27
  19. Weed DW , Yan D , Martinez AA , et al.   The validity of surgical clips as a radiographic surrogate for the lumpectomy cavity in image-guided accelerated partial breast irradiation . Int J Radiat Oncol Biol Phys . 2004;60:484–492
  20. Fein DA , Fowble BL , Hanlon AL , et al.   Does the placement of surgical clips within the excision cavity influence local control for patients treated with breast-conserving surgery and irradiation? . Int J Radiat Oncol Biol Phys . 1996;34:1009–1017

 Note—An online CME test for this article can be taken at www.astro.org under Education and Meetings.

PII: S0360-3016(06)00692-4

doi: 10.1016/j.ijrobp.2006.04.042

International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 3 , Pages 680-686 , 1 November 2006