International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 3 , Pages 687-690 , 1 November 2006

The effect of timing of radiotherapy after breast-conserving surgery in patients with positive or close resection margins, young age, and node-negative disease, with long term follow-up

  • Olga Vujovic, M.D.

      Affiliations

    • Department of Radiation Oncology, London Regional Cancer Program, London, Ontario, Canada
    • Corresponding Author InformationReprint requests to: Olga Vujovic, M.D., Department of Radiation Oncology, London Regional Cancer Program, 790 Commissioners Road East, London, ON, Canada, N6A 4L6. Tel: (519) 685-8650; Fax: (519) 685-8736
    • ,
  • Anil Cherian, M.B.B.S., M.R.C.S. (Glasg)

      Affiliations

    • Department of Medical Oncology, London Regional Cancer Program, London, Ontario, Canada
    • ,
  • Edward Yu, M.D.

      Affiliations

    • Department of Radiation Oncology, London Regional Cancer Program, London, Ontario, Canada
    • ,
  • A. Rashid Dar, M.D.

      Affiliations

    • Department of Radiation Oncology, London Regional Cancer Program, London, Ontario, Canada
    • ,
  • Larry Stitt, M.Sc.

      Affiliations

    • Clinical Research Unit, London Regional Cancer Program, London, Ontario, Canada
    • ,
  • Francisco Perera, M.D.

      Affiliations

    • Department of Radiation Oncology, London Regional Cancer Program, London, Ontario, Canada

Received 28 February 2006 ,Revised 5 May 2006 ,Accepted 24 May 2006.

References 

  1. Fourquet A , Campana F , Zafrani B , et al.   Prognostic factors of breast recurrence in the conservative management of early breast cancer . Int J Radiat Oncol Biol Phys . 1989;17:719–725
  2. Schnitt SJ , Abrer A , Gelman R , et al.   The relationship between microscopic margins of resection and the risk of local recurrence in patients with breast cancer treated with breast-conserving surgery and radiation therapy . Cancer . 1994;74:746–1751
  3. Smitt MC , Nowels KW , Zdeblick MJ , et al.   The importance of the lumpectomy surgical margin status in long-term results of breast conservation . Cancer . 1995;76:259–267
  4. Recht A , Connolly JL , Schmitt JJ , et al.   The effect of young age on tumor recurrence in the treated breast after conservative surgery and radiotherapy . Int J Radiat Oncol Biol Phys . 1988;14:3–9
  5. Fowble BL , Shultz DJ , Overmoyer B , et al.   The influence of young age on outcome in early stage breast cancer . Int J Radiat Oncol Biol Phys . 1994;30:23–33
  6. Borger J , Kemperman H , Hart A , et al.   Risk factors in breast-conserving therapy . J Clin Oncol . 1994;12:653–660
  7. Smitt MC , Nowels K , Carlson RW , et al.   Predictors of re-excision findings and recurrence after breast conservation . Int J Radiat Oncol Biol Phys . 2003;57:979–985
  8. Recht A , Come S , Henderson IC , et al.   The sequencing of chemotherapy and radiation therapy after conservative surgery for early breast cancer . N Engl J Med . 1996;334:1356–1361
  9. Freedman G , Fowble B , Hanlon A , et al.   Patients with early stage invasive breast cancer with close or positive margins treated with conservative surgery recurrence that is delayed by adjuvant systemic therapy . Int J Radiat Oncol Biol Physics . 1999;44:1005–1015
  10. Vujovic O , Perera F , Dar AR , et al.   Does delay in breast irradiation following conservative breast surgery in node-negative breast cancer patients have an impact on risk of recurrence? . Int J Radiat Oncol Biol Phys . 1998;40:869–874
  11. Bloom HJG , Richardson WW . Histological grading and prognosis in breast cancer . Br J Cancer . 1957;11:359–377
  12. Lu ET . In: Statistical methods for survival data analysis . 2nd ed. New York: John Wiley & Sons; 1992;
  13. In: AJCC cancer staging handbook . 6th ed.. New York: Springer-Verlog; 2002;
  14. Froud PJ , Mates D , Jackson JJ , et al.   Effect of time interval between breast-conserving surgery and radiation therapy on ipsilateral breast recurrence . Int J Radiat Oncol Biol Phys . 2000;46:363–372
  15. Bartelink H , Horiot JC , Poortmans P , et al.   Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation . N Engl J Med . 2001;345:1378–1387

PII: S0360-3016(06)00978-3

doi: 10.1016/j.ijrobp.2006.05.051

International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 3 , Pages 687-690 , 1 November 2006

Article Tools

* Image Usage & Resolution