International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 4 , Pages 992-1003 , 15 November 2006

A prognostic scoring system for locoregional control in nasopharyngeal carcinoma following conformal radiotherapy

  • Skye Hongiun Cheng, M.D.

      Affiliations

    • Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
    • Department of Research, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
    • Department of Radiation Oncology, Duke University, Durham, NC, USA
    • Corresponding Author InformationReprint requests to: Skye H. Cheng, M.D., Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, No. 125, Lih-Der Road, Pei-Tou District, Taipei, Taiwan. Tel: (+886) 2-754-9152, Ext. 310; Fax: (+886) 2-707-9123.
  • ,
  • Stella Y. Tsai, M.D.

      Affiliations

    • Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
    • Department of Radiation Oncology, Duke University, Durham, NC, USA
  • ,
  • Cheng-Fang Horng, M.S.

      Affiliations

    • Department of Research, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
  • ,
  • K. Lawrence Yen, M.D.

      Affiliations

    • Department of Head and Neck Surgery, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
  • ,
  • James J. Jian, M.D.

      Affiliations

    • Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
    • Department of Radiation Oncology, Duke University, Durham, NC, USA
  • ,
  • Kwan-Yee Chan, M.D.

      Affiliations

    • Department of Radiology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
  • ,
  • Ching-Yuan Lin, M.D.

      Affiliations

    • Department of Head and Neck Surgery, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
  • ,
  • Shian-Der Terng, M.D.

      Affiliations

    • Department of Head and Neck Surgery, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
  • ,
  • Mei-Hua Tsou, M.D.

      Affiliations

    • Department of Medical Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
  • ,
  • Nei-Min Chu, M.D.

      Affiliations

    • Department of Pathology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
  • ,
  • Hsin-Hsian Chen, M.D.

      Affiliations

    • Department of Pathology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
  • ,
  • Pei-Lin Chen, B.C.

      Affiliations

    • Department of Research, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
  • ,
  • Y.L. Chung, M.D.

      Affiliations

    • Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
  • ,
  • Cheng-I. Hsieh, M.D.

      Affiliations

    • Department of Pathology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
  • ,
  • Tran-Der Tan, M.D.

      Affiliations

    • Department of Pathology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
  • ,
  • Andrew T. Huang, M.D.

      Affiliations

    • Department of Pathology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
    • Department of Medicine, Duke University, Durham, NC, USA

Received 11 March 2006 ,Revised 6 June 2006 ,Accepted 6 June 2006.

References 

  1. Lee AW, Sze WM, Au JS, et al. Treatment results for nasopharyngeal carcinoma in the modern era: The Hong Kong experience. Int J Radiat Oncol Biol Phys. 2005;61:1107–1116
  2. Lin ZX, Li DR, Chen ZJ, et al. What is the significance of nasal involvement in nasopharyngeal carcinoma?. Int J Radiat Oncol Biol Phys. 1999;45:907–914
  3. Cheng SH, Yen KL, Jian JJ, et al. Examining prognostic factors and patterns of failure in nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy: Impact on future clinical trials. Int J Radiat Oncol Biol Phys. 2001;50:717–726
  4. Chua DT, Sham JS, Kwong DL, et al. Volumetric analysis of tumor extent in nasopharyngeal carcinoma and correlation with treatment outcome. Int J Radiat Oncol Biol Phys. 1997;39:711–719
  5. Sze WM, Lee AW, Yau TK, et al. Primary tumor volume of nasopharyngeal carcinoma: Prognostic significance for local control. Int J Radiat Oncol Biol Phys. 2004;59:21–27
  6. Wei WI, Sham JS. Nasopharyngeal carcinoma. Lancet. 2005;365:2041–2054
  7. Lee N, Xia P, Quivey JM, et al. Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: An update of the UCSF experience. Int J Radiat Oncol Biol Phys. 2002;53:12–22
  8. Kam MK, Teo PM, Chau RM, et al. Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: The Hong Kong experience. Int J Radiat Oncol Biol Phys. 2004;60:1440–1450
  9. Anderberg MR. Cluster analysis for applications. New York: Academic Press; 1973;
  10. Cox D. Regression models and life-tables. J R Stat Soc. 1972;34:187–220
  11. Cheng SH, Tsai SY, Yen KL, et al. Prognostic significance of parapharyngeal space venous plexus and marrow involvement: Potential landmarks of dissemination for stage I-III nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 2005;61:456–465
  12. Jian JJ, Cheng SH, Prosnitz LR, et al. T classification and clivus margin as risk factors for determining locoregional control by radiotherapy of nasopharyngeal carcinoma. Cancer. 1998;82:261–267
  13. Cheng SH, Jian JJ, Tsai SY, et al. Prognostic features and treatment outcome in locoregionally advanced nasopharyngeal carcinoma following concurrent chemotherapy and radiotherapy. Int J Radiat Oncol Biol Phys. 1998;41:755–762
  14. Cheng SH, Tsou MH, Liu MC, et al. Unique features of breast cancer in Taiwan. Breast Cancer Res Treat. 2000;63:213–223
  15. SAS software, v. 8 for Microsoft Windows. Cary, NC: SAS Institute; 1999;
  16. Sakai O, Curtin HD, Romo LV, et al. Lymph node pathology (Benign proliferative, lymphoma, and metastatic disease). Radiol Clin North Am. 2000;38:979–998
  17. Kaplan EL, Meier P. Nonparametric estimation from incomplete observation. J Am Stat Assoc. 1958;53:457–481
  18. Mantel N, Haenszel W. Chi-square test with one degree of freedom: Extensions of the Mantel-Haenszel procedure. J Am Stat Soc. 1963;58:690–700
  19. Farias TP, Dias FL, Lima RA, et al. Prognostic factors and outcome for nasopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 2003;129:794–799
  20. Ozyar E, Gurkaynak M, Yildiz F, et al. Non-metastatic stage IV nasopharyngeal carcinoma patients: Analysis of the pattern of relapse and survival. Radiother Oncol. 2004;72:71–77
  21. A predictive model for aggressive non-Hodgkin’s lymphoma (The International Non-Hodgkin’s Lymphoma Prognostic Factors Project). N Engl J Med. 1993;329:987–994
  22. Shamash J, Oliver RT, Gallagher CJ, et al. Pre-induction LDH as a prognostic factor for outcome of high dose chemotherapy (HDCT) for germ cell tumours relapsing or refractory to conventional chemotherapy. Br J Cancer. 2000;82:2022–2023
  23. Byhardt RW, Hartz A, Libnoch JA, et al. Prognostic influence of TNM staging and LDH levels in small cell carcinoma of the lung (SCCL). Int J Radiat Oncol Biol Phys. 1986;12:771–777
  24. Hong RL, Ting LL, Ko JY, et al. Induction chemotherapy with mitomycin, epirubicin, cisplatin, fluorouracil, and leucovorin followed by radiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma. J Clin Oncol. 2001;19:4305–4313
  25. Lee AW, Lau WH, Tung SY, et al. Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group. J Clin Oncol. 2005;23:6966–6975
  26. Consensus conference (Magnetic resonance imaging). JAMA. 1988;259:2132–2138
  27. van’t Veer LJ, Dai H, van de Vijver MJ, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002;415:530–536
  28. Levendag P, Braaksma M, Coche E, et al. Rotterdam and Brussels CT-based neck nodal delineation compared with the surgical levels as defined by the American Academy of Otolaryngology-Head and Neck Surgery. Int J Radiat Oncol Biol Phys. 2004;58:113–123
  29. Chang CC, Chen MK, Liu MT, et al. The effect of primary tumor volumes in advanced T-staged nasopharyngeal tumors. Head Neck. 2002;24:940–946
  30. Kim JH, Lee JK. Prognostic value of tumor volume in nasopharyngeal carcinoma. Yonsei Med J. 2005;46:221–227
  31. Sakata K, Hareyama M, Tamakawa M, et al. Prognostic factors of nasopharynx tumors investigated by MR imaging and the value of MR imaging in the newly published TNM staging. Int J Radiat Oncol Biol Phys. 1999;43:273–278
  32. Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors (European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada). J Natl Cancer Inst. 2000;92:205–216
  33. Lin JC, Chen KY, Wang WY, et al. Detection of Epstein-Barr virus DNA the peripheral-blood cells of patients with nasopharyngeal carcinoma: Relationship to distant metastasis and survival. J Clin Oncol. 2001;19:2607–2615
  34. Hunt MA, Zelefsky MJ, Wolden S, et al. Treatment planning and delivery of intensity-modulated radiation therapy for primary nasopharynx cancer. Int J Radiat Oncol Biol Phys. 2001;49:623–632

 This study was supported by a grant from the National Health Research Institutes of Taiwan (NHRI-EX94-9216BI) and research fund of Koo Foundation Sun Yat-Sen Cancer Center.

PII: S0360-3016(06)00992-8

doi: 10.1016/j.ijrobp.2006.06.006

International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 4 , Pages 992-1003 , 15 November 2006