International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 4 , Pages 1004-1010 , 15 November 2006

Treatment of Stage IV(A–B) nasopharyngeal carcinoma by induction-concurrent chemoradiotherapy and accelerated fractionation: Impact of chemotherapy schemes

Received 28 April 2006 ,Revised 6 June 2006 ,Accepted 6 June 2006.

References 

  1. Lee AWM, Sze WM, Au JS, et al. Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience. Int J Radiat Oncol Biol Phys. 2005;61:1107–1116
  2. Al-Sarraf M, LeBlanc M, Giri PGS, et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: Phase III randomized Intergroup Study 0099. J Clin Oncol. 1998;16:1310–1317
  3. Wee J, Tan EH, Tai BC, et al. Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety. J Clin Oncol. 2005;23:6730–6738
  4. Lee AWM, Lau WH, Tung SY, et al. Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group. J Clin Oncol. 2005;23:6966–6975
  5. Langendijk JA, Leemans Ch R, Buter J, et al. The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: A meta-analyses of the published literature. J Clin Oncol. 2004;22:4604–4612
  6. Baujat B, Audry H, Bourhis J, et al. Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patients. Int J Radiat Oncol Biol Phys. 2006;64:47–56
  7. Chan AT, Ma BB, Lo YM, et al. Phase II study of neoadjuvant carboplatin and paclitaxel followed by radiotherapy and concurrent cisplatin in patients with locoregionally advanced nasopharyngeal carcinoma: Therapeutic monitoring with plasma Epstein-Barr virus DNA. J Clin Oncol. 2004;22:3053–3060
  8. Johnson FM, Garden A, Palmer JL, et al. A Phase II study of docetaxel and carboplatin as neoadjuvant therapy for nasopharyngeal carcinoma with early T status and advanced N status. Cancer. 2004;100:991–998
  9. Lee AWM, Yau TK, Wong HM, et al. Treatment of Stage IV(A–B) Nasopharyngeal carcinoma by induction-concurrent chemoradiotherapy and accelerated fractionation. Int J Radiat Oncol Biol Phys. 2005;63:1331–1338
  10. Yau TK, Lee AWM, Wong DHM, et al. Induction chemotherapy with cisplatin and gemcitabine followed by accelerated radiotherapy and concurrent cisplatin in patients with stage IV(A–B) nasopharyngeal carcinoma. Head Neck. 2006;28:880–887
  11. Schwartz DL, Montgomery RB, Yueh B, et al. Phase I and initial phase II results from a trial investigating weekly docetaxel and carboplatin given neoadjuvantly and then concurrently with concomitant boost radiotherapy for locally advanced squamous cell carcinoma of the head and neck. Cancer. 2005;103:2534–2543
  12. Belani CP, Choy H, Bonomi P, et al. Combined chemoradiotherapy regimens of paclitaxel and carboplatin for locally advanced non-small-cell lung cancer: A randomized phase II locally advanced multi-modality protocol. J Clin Oncol. 2005;23:5883–5891
  13. Dubay RA, Rose PG, O’Malley DM, et al. Evaluation of concurrent and adjuvant carboplatin with radiation therapy for locally advanced cervical cancer. Gynecol Oncol. 2004;94:121–124
  14. Fleming ID, Cooper JS, Henson DE, et al. American Joint Committee on Cancer: AJCC Cancer Staging Manual. 5th ed.. Philadelphia: Lippincott-Raven; 1997;
  15. Sobin LH, Wittekind C. International Union Against Cancer (UICC): TNM classification of malignant tumors. 5th ed.. New York: Wiley-Liss; 1997;
  16. Cvitkovic E, Eschwege F, Rahal M, et al. Preliminary results of trial comparing neoadjuvant chemotherapy (cisplatin, epirubicin, bleomycin) plus radiotherapy vs radiotherapy alone in stage IV (≥N2, M0) undifferentiated nasopharyngeal carcinoma: A positive effect on progression free survival. Int J Radiat Oncol Biol Phys. 1996;35:463–469
  17. Chua DT, Sham JS, Choy D, et al. Preliminary report of the Asian-Oceanian Clinical Oncology Association randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with locoregionally advanced nasopharyngeal carcinoma. Cancer. 1998;83:2270–2283
  18. De Andres L, Brunet J, Lopez-Pousa A, et al. Randomised trial of neoadjuvant cisplatin and fluorouracil versus carboplatin and fluorouracil in patients with stage IV-M0 head and neck cancer. J Clin Oncol. 1995;13:1493–1500
  19. Welkoborsky HJ, Bleier R, Wissen-Siegert I. Antineoplastic effectiveness and unwanted side effects of polychemotherapy of extensive oro- and hypopharyngeal cancers: Results of a prospective therapy study with 5-FU/cisplatin versus 5-FU/carboplatin. Laryngol Rhinol Otol. 1992;71:261–266
  20. Douple EB, Richmond RC, O’Hara JA, et al. Carboplatin as a potentiator of radiation therapy. Cancer Treat Rev. 1985;12:111–124
  21. Parliament M, Jha N, Rapp E, et al. Concurrent weekly carboplatin and radiotherapy for nasopharyngeal carcinoma: Report of a joint phase II study. Radiother Oncol. 2001;58:131–136
  22. McDermott DF, Galindo A, Sherman RL, et al. Inadequacy of predicted creatinine clearance as guide to chemotherapy. Cancer Treat Rep. 1987;71:1067–1069
  23. Chang GC, Yang TY, Shih CM, et al. Serial-measured versus estimated creatinine clearance in patients with non-small cell lung cnacer receiving cisplatin-based chemotherapy. J Formos Med Assoc. 2003;102:257–261
  24. Martin L, Chatelut E, Boneu A, et al. Improvement of the Cockcroft-Gault equation for predicting glomerular filtration in cancer patients. Bull Cancer. 1998;85:631–636

 This study is supported in part by grants from the Hong Kong Cancer Fund.

PII: S0360-3016(06)01040-6

doi: 10.1016/j.ijrobp.2006.06.016

International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 4 , Pages 1004-1010 , 15 November 2006

Article Tools

* Image Usage & Resolution