International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 3 , Pages 637-646, 1 November 2006

ReVOLT: radiation-enhanced viral oncolytic therapy

  • Sunil J. Advani, M.D.

      Affiliations

    • Department of Radiation and Cellular Oncology, the University of Chicago, Chicago, IL
    • ,
  • James J. Mezhir, M.D.

      Affiliations

    • Department of Surgery, the University of Chicago, Chicago, IL
    • ,
  • Bernard Roizman, Sc.D.

      Affiliations

    • Marjorie B. Kovler Viral Oncology Laboratories, the University of Chicago, Chicago, IL
    • ,
  • Ralph R. Weichselbaum, M.D.

      Affiliations

    • Department of Radiation and Cellular Oncology, the University of Chicago, Chicago, IL
    • Corresponding Author InformationReprint requests to: Ralph R. Weichselbaum, M.D., Department of Radiation and Cellular Oncology, The University of Chicago Hospitals, Center for Advanced Medicine, Room 1329, Mail Code 9006, 5758 South Maryland Avenue, Chicago, IL 60637. Tel: (773) 702-0817; Fax: (773) 834-7233

Received 4 April 2006; received in revised form 15 June 2006; accepted 16 June 2006.

Viral oncolytic therapy has been pursued with renewed interest as the molecular basis of carcinogenesis and viral replication has been elucidated. Genetically engineered, attenuated viruses have been rationally constructed to achieve a therapeutic index in tumor cells compared with surrounding normal tissue. Many of these attenuated mutant viruses have entered clinical trials. Here we review the preclinical literature demonstrating the interaction of oncolytic viruses with ionizing radiation and provides a basis for future clinical trials.

Keywords:  Ionizing radiation , Viral oncolysis , Radiation enhanced viral replication , Cancer

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 Support provided in part by NCI Program Project PO1 CA7193307-08, and a gift from Mr. and Mrs. Vincent W. Foglia

PII: S0360-3016(06)01111-4

doi:10.1016/j.ijrobp.2006.06.034

International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 3 , Pages 637-646, 1 November 2006

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