International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 3 , Pages 647-653 , 1 November 2006

Whole-pelvis, “mini-pelvis,” or prostate-only external beam radiotherapy after neoadjuvant and concurrent hormonal therapy in patients treated in the Radiation Therapy Oncology Group 9413 trial

  • Mack Roach III, M.D., F.A.C.R.

      Affiliations

    • University of California San Francisco, San Francisco, CA
    • Corresponding Author InformationReprint requests to: Mack Roach III, M.D., University of California San Francisco, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143-1708. Tel: (415) 353-7175; Fax: (415) 353-9883;
    • ,
  • Michelle DeSilvio, Ph.D.

      Affiliations

    • RTOG Statistical Headquarters, Philadelphia, PA
    • ,
  • Richard Valicenti, M.D.

      Affiliations

    • Thomas Jefferson University, Philadelphia, PA
    • ,
  • David Grignon, M.D.

      Affiliations

    • Wayne State University, Detroit, MI
    • ,
  • Sucha O. Asbell, M.D.

      Affiliations

    • Albert Einstein Medical Center, Philadelphia, PA
    • ,
  • Colleen Lawton, M.D.

      Affiliations

    • Medical College of Wisconsin, Milwaukee, WI
    • ,
  • Charles R. Thomas Jr., M.D.

      Affiliations

    • Oregon Health and Sciences University, Portland OR
    • ,
  • William U. Shipley, M.D.

      Affiliations

    • Massachusetts General Hospital, Boston, MA

Received 27 April 2006 ,Revised 29 May 2006 ,Accepted 31 May 2006.

References 

  1. Pilepich MV , Krall JM , Al-Sarraf M , et al.   Androgen deprivation with radiation therapy compared with radiation therapy alone for locally advanced prostatic carcinoma: a randomized comparative trial of the Radiation Therapy Oncology Group . Urology . 1995;45:616–623
  2. Laverdiere J , Gomez JL , Cusan L , et al.   Beneficial effect of combination hormonal therapy administered prior and following external beam radiation therapy in localized prostate cancer . Int J Radiat Oncol Biol Phys . 1997;37:247–252
  3. D’Amico AV , Manola J , Loffredo M , et al.   6-Month androgen suppression plus radiation therapy vs radiation therapy alone for patients with clinically localized prostate cancer: a randomized controlled trial . Jama . 2004;292:821–827
  4. Denham JW , Steigler A , Lamb DS , et al.   Short-term androgen deprivation and radiotherapy for locally advanced prostate cancer: results from the Trans-Tasman Radiation Oncology Group 96.01 randomised controlled trial . Lancet Oncol . 2005;6:841–850
  5. Roach M , DeSilvio M , Lawton C , et al.  Radiation Therapy Oncology Group 9413   Phase III trial comparing whole-pelvic versus prostate-only radiotherapy and neoadjuvant versus adjuvant combined androgen suppression . J Clin Oncol . 2003;21:1904–1911
  6. Ennis RD . Uncertainties regarding pelvic radiotherapy for prostate cancer . J Clin Oncol . 2004;22:2254–2255
  7. Roach M . Hormonal therapy and radiotherapy for localized prostate cancer: who, where and how long? . J Urol . 2003;170:S35–S40 discussion S40–S31
  8. Thames H , Kuban D , Levy L , et al.   Comparison of alternative biochemical failure definitions based on clinical outcome in 4839 prostate cancer patients treated by external beam radiotherapy between 1986 and 1995 . Int J Radiat Oncol Biol Phys . 2003;57:929–943
  9. Pickles T , Kim-Sing C , Morris WJ , et al.   Evaluation of the Houston biochemical relapse definition in men treated with prolonged neoadjuvant and adjuvant androgen ablation and assessment of follow-up lead-time bias . Int J Radiat Oncol Biol Phys . 2003;57:11–18
  10. Jacob R , Hanlon AL , Horwitz EM , et al.   Role of prostate dose escalation in patients with greater than 15% risk of pelvic lymph node involvement . Int J Radiat Oncol Biol Phys . 2005;61:695–701
  11. Foley CL , Bott SR , Thomas K , et al.   A large prostate at radical retropubic prostatectomy does not adversely affect cancer control, continence or potency rates . BJU Int . 2003;92:370–374
  12. Lehrer S , Stone NN , Stock RG . Prostate cancer in a large prostate is associated with a decreased prostate specific antigen failure rate after brachytherapy . J Urol . 2005;173:79–81
  13. Freedland SJ , Isaacs WB , Platz EA , et al.   Prostate size and risk of high-grade, advanced prostate cancer and biochemical progression after radical prostatectomy: a search database study . J Clin Oncol . 2005;23:7546–7554
  14. Hanks GE , Hanlon AL , Epstein B , et al.   Dose response in prostate cancer with 8–12 years’ follow-up . Int J Radiat Oncol Biol Phys . 2002;54:427–435
  15. Zelefsky MJ , Fuks Z , Happersett L , et al.   Clinical experience with intensity modulated radiation therapy (IMRT) in prostate cancer . Radiother Oncol . 2000;55:241–249
  16. Wang-Cheseboro A , Xia P , Coleman J , Akazawa C , Roach M . Intensity-modulated radiotherapy improves lymph node coverage and dose to critical structures compared with three-dimensional conformal radiation therapy in clinically localized prostate cancer . Int J Radiat Oncol Biol Phys . 2006;66:654–662

 The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute.Supported by Grants No. RTOG U10 CA21661, CCOP U10 CA37422, Stat U10 CA32115 from the National Cancer Institute, National Institutes of Health, Bethesda, MD.

PII: S0360-3016(06)01120-5

doi: 10.1016/j.ijrobp.2006.05.074

International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 3 , Pages 647-653 , 1 November 2006

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