International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 4 , Pages 966-974 , 15 November 2006

A comparison of intensity-modulated radiation therapy and concomitant boost radiotherapy in the setting of concurrent chemotherapy for locally advanced oropharyngeal carcinoma

  • Nancy Y. Lee, M.D.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY
    • Corresponding Author InformationReprint requests to: Nancy Y. Lee, M.D., Memorial Sloan-Kettering Cancer Center, Department of Radiation Oncology, 1275 York Avenue, Box 22, New York, NY 10021. Tel: (212) 639-3341; Fax: (212) 717-3104
  • ,
  • Fernando F. de Arruda, M.D.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY
    • Dr. de Arruda is currently affiliated with Sirio Libanes Hospital in Sao Paulo, Brazil.
  • ,
  • Dev R. Puri, M.D.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY
  • ,
  • Suzanne L. Wolden, M.D.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY
  • ,
  • Ashwatha Narayana, M.D.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY
  • ,
  • James Mechalakos, Ph.D.

      Affiliations

    • Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY
  • ,
  • Ennapadam S. Venkatraman, M.D.

      Affiliations

    • Department of Biostatics, Memorial Sloan-Kettering Cancer Center, New York, NY
  • ,
  • Dennis Kraus, M.D.

      Affiliations

    • Department of Surgery, Division of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY
  • ,
  • Ashok Shaha, M.D.

      Affiliations

    • Department of Surgery, Division of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY
  • ,
  • Jatin P. Shah, M.D.

      Affiliations

    • Department of Surgery, Division of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY
  • ,
  • David G. Pfister, M.D.

      Affiliations

    • Department of Medicine, Division of Head and Neck Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY
  • ,
  • Michael J. Zelefsky, M.D.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY

Received 1 May 2006 ,Revised 3 June 2006 ,Accepted 6 June 2006.

References 

  1. Lindberg R. Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer. 1972;29:1446–1449
  2. Bernier J, Domenge C, Ozsahin M, et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 2004;350:1945–1952
  3. Cooper JS, Pajak TF, Forastiere AA, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004;350:1937–1944
  4. Pignon JP, Bourhis J, Domenge C, et al. MACH-NC Collaborative Group Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data (Meta-Analysis of Chemotherapy on Head and Neck Cancer). Lancet. 2000;355:949–955
  5. Adelstein DJ, Lavertu P, Saxton JP, et al. Mature results of a phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with stage III and IV squamous cell carcinoma of the head and neck. Cancer. 2000;88:876–883
  6. Denis F, Garaud P, Bardet E, et al. Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma. J Clin Oncol. 2004;22:69–76
  7. Bourhis J, Amand C, Pignon JP. Update of MACH-NC (Meta-Anlysis of Chemotherapy in Head and Neck Cancer) database focused on concomitant chemoradiotherapy. [Abstract] Proc Am Soc Clin Oncol. 2005;23:489s
  8. Adelstein DJ, Li Y, Adams GL, et al. An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol. 2003;21:92–98
  9. Staar S, Rudat V, Stuetzer H, et al. Intensified hyperfractionated accelerated radiotherapy limits the additional benefit of simultaneous chemotherapy—results of a multicentric randomized German trial in advanced head-and-neck cancer. [see comment] [erratum appears in Int J Radiat Oncol Biol Phys 2001;51:569] Int J Radiat Oncol Biol Phys. 2001;50:1161–1171
  10. Denis F, Garaud P, Bardet E, et al. Late toxicity results of the GORTEC 94-01 randomized trial comparing radiotherapy with concomitant radiochemotherapy for advanced-stage oropharynx carcinoma: comparison of LENT/SOMA, RTOG/EORTC, and NCI-CTC scoring systems. Int J Radiat Oncol Biol Phys. 2003;55:93–98
  11. Fu KK, Pajak TF, Trotti A. A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. Int J Radiat Oncol Biol Phys. 2000;48:7–16
  12. Nutting C, Dearnaley DP, Webb S. Intensity modulated radiation therapy: a clinical review. Br J Radiol. 2000;73:459–469
  13. Xia P, Fu KK, Wong GW, et al. Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 2000;48:329–337
  14. Hunt MA, Zelefsky MJ, Wolden S, et al. Treatment planning and delivery of intensity-modulated radiation therapy for primary nasopharynx cancer. Int J Radiat Oncol Biol Phys. 2001;49:623–632
  15. Eisbruch A, Dawson LA, Kim HM, et al. Conformal and intensity modulated irradiation of head and neck cancer: the potential for improved target irradiation, salivary gland function, and quality of life. Acta Oto-Rhino-Laryngol Belgica. 1999;53:271–275
  16. Chui CS, Chan MF, Yorke E, et al. Delivery of intensity-modulated radiation therapy with a conventional multileaf collimator: comparison of dynamic and segmental methods. Med Phys. 2001;28:2441–2449
  17. Eisbruch A, Kim HM, Terrell JE, et al. Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001;50:695–704
  18. Chao KS, Majhail N, Huang CJ, et al. Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques. Radiother Oncol. 2001;61:275–280
  19. Kam MK, Leung SF, Zee B, et al. Impact of Intenstiy-modulated radiotherapy (IMRT) on salivary gland function in early-stage nasopharyngeal carcinoma (NPC) patients. [Abstract] Proc Am Soc Clin Oncol. 2005;23:500s
  20. Chui CS, Spirou SV. Inverse planning algorithms for external beam radiation therapy. Med Dosim. 2001;26:189–197
  21. Harrison LB, Pfister DG, Fass DE, et al. Concomitant chemotherapy-radiation therapy followed by hyperfractionated radiation therapy for advanced unresectable head and neck cancer. Intl J Radiat Oncol Biol Phys. 1991;21:703–708
  22. de Arruda FF, Puri DR, Zhung J, et al. Intensity-modulated radiation therapy (IMRT) for advanced oropharyngeal carcinoma: the MSKCC experience. Int J Radiat Oncol Biol Phys. 2006;64:363–373
  23. Adelstein DJ, Saxton JP, Lavertu P, et al. Maximizing local control and organ preservation in stage IV squamous cell head and neck cancer with hyperfractionated radiation and concurrent chemotherapy. J Clin Oncol. 2002;20:1405–1410
  24. Vokes EE, Pajak TF. Enhancing the therapeutic index of concomitant chemoradiotherapy for head and neck cancer. Ann Oncol. 1998;9:471–473
  25. Kies MS, Bennett CL, Vokes EE. Locally advanced head and neck cancer. Curr Treatment Options Oncol. 2001;2:7–13
  26. Garden AS, Harris J, Jones C, et al. Concomitant boost radiation and concurrent cisplatin for advanced head and neck carcinomas: update of a phase III trial of the RTOG (99-14). [Abstract] Int J Radiat Oncol Biol Phys. 2005;63:S71–S72
  27. Trotti A, Fu KK, Pajak TF, et al. Long term outcomes of RTOG 90-03: a comparison of hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2005;63:S70–S71
  28. Thames HD, Whithers H, Peters LJ. Changes in early and late radiation responses with altered dose per fraction: implications for dose-survival relationships. Int J Radiat Oncol Biol Phys. 1982;8:219–226
  29. Brizel DM, Albers ME, Fisher SR, et al. Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. N Engl J Med. 1998;338:1798–1804
  30. Budach V, Stuschke M, Budach W, et al. Hyperfractionated accelerated chemoradiation with concurrent fluorouracil-mitomycin is more effective than dose-escalated hyperfractionated accelerated radiation therapy alone in locally advanced head and neck cancer: final results of the radiotherapy cooperative clinical trials group of the German Cancer Society 95-06 Prospective Randomized Trial. J Clin Oncol. 2005;23:1125–1135
  31. Lamont EB, Vokes EE. Chemotherapy in the management of squamous-cell carcinoma of the head and neck. Lancet Oncol. 2001;2:261–269
  32. Leibel SA, Fuks Z, Zelefsky MJ, et al. Intensity-modulated radiotherapy. Cancer J. 2002;8:164–176
  33. Chao KS. Protection of salivary function by intensity-modulated radiation therapy in patients with head and neck cancer. Semin Radiat Oncol. 2002;12:20–25
  34. Eisbruch A, Ship JA, Dawson LA, et al. Salivary gland sparing and improved target irradiation by conformal and intensity modulated irradiation of head and neck cancer. World J Surg. 2003;27:832–837
  35. Gregoire V, Maingon P. Intensity-modulated radiation therapy in head and neck squamous cell carcinoma: an adaptation of 2-dimensional concepts or a reconsideration of current clinical practice. Semin Radiat Oncol. 2004;110–120
  36. Chao KS, Low DA, Perez CA, et al. Intensity-modulated radiation therapy in head and neck cancers: the Mallinckrodt experience. Int J Cancer. 2000;90:92–103
  37. Pacholke HD, Amdur RJ, Morris CM. Late xerostomia after intensity-modulated radiation therapy versus conventional radiotherapy. Am J Clin Oncol. 2005;28:351–358
  38. Lee N, Xia P, Quivey JM, et al. Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience. Int J Radiat Oncol Biol Phys. 2002;53:12–22
  39. Huang E, Teh BS, Strother DR. Intensity-modulated radiation therapy for pediatric medulloblastoma: early report on the reduction of ototoxicity. Int J Radiat Oncol Biol Phys. 2002;52:599–605
  40. Wolden S, Chen CW, Pfister DG. Intensity-modulated radiation therapy (IMRT) for nasopharynx cancer: update of the Memorial Sloan-kettering experience. Int J Radiat Oncol Biol Phys. 2006;64:57–62
  41. Eisbruch A, Marsh LH, Dawson LA, et al. Recurrences near base of skull after IMRT for head-and-neck cancer: implications for target delineation in high neck and for parotid gland sparing. Int J Radiat Oncol Biol Phys. 2004;59:28–42
  42. Chao KS, Ozyigit G, Blanco AI, et al. Intensity-modulated radiation therapy for oropharyngeal carcinoma: impact of tumor volume. Int J Radiat Oncol Biol Phys. 2004;59:43–50

PII: S0360-3016(06)01127-8

doi: 10.1016/j.ijrobp.2006.06.040

International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 4 , Pages 966-974 , 15 November 2006