International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 5 , Pages 1335-1338 , 1 December 2006

Targeted intraoperative radiotherapy (TARGIT) yields very low recurrence rates when given as a boost

  • Jayant S. Vaidya, M.B.B.S., M.S., D.N.B., F.R.C.S., Ph.D., F.R.C.S. (GEN)

      Affiliations

    • Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
    • Corresponding Author InformationReprint requests to: Jayant S. Vaidya, M.B.B.S., M.S., D.N.B., F.R.C.S., Ph.D., F.R.C.S. (GEN), Surgery and Molecular Oncology, Level 6, Ninewells Hospital and Medical School, University of Dundee, DD12UY, Dundee, Scotland, United Kingdom. Tel: (+44) 138-266-0111; Fax: (+44) 138-249-6363
    • ,
  • Michael Baum, M.B., F.R.C.S., C.H.M., M.D.(HON), F.R.C.R.(HON)

      Affiliations

    • Department of Surgery and Radiation Oncology, University College London, London, United Kingdom
    • ,
  • Jeffrey S. Tobias, M.D., F.R.C.R.

      Affiliations

    • Department of Surgery and Radiation Oncology, University College London, London, United Kingdom
    • ,
  • Samuele Massarut, M.D.

      Affiliations

    • Mannheim Medical Center, University of Mannheim, Mannheim, Germany
    • ,
  • Frederik Wenz, M.D.

      Affiliations

    • Department of Surgery and Radiation Oncology, Centro di Riferimento Oncologico (CRO), Aviano, Italy
    • ,
  • Olive Murphy, B.Sc.

      Affiliations

    • Department of Surgery and Radiation Oncology, University College London, London, United Kingdom
    • ,
  • Basil Hilaris, M.D.

      Affiliations

    • Department of Radiation Oncology, Our Lady of Mercy, New York Medical College, New York, NY
    • ,
  • Joan Houghton, B.Sc.

      Affiliations

    • Department of Surgery and Radiation Oncology, University College London, London, United Kingdom
    • ,
  • Christobel Saunders, M.D., F.R.C.S.

      Affiliations

    • Department of Radiation Oncology, Sir Charles Gairdner Hospital and School of Surgery and Pathology, University of Western Australia, Perth, Australia
    • ,
  • Tammy Corica, B.Sc.

      Affiliations

    • Department of Radiation Oncology, Sir Charles Gairdner Hospital and School of Surgery and Pathology, University of Western Australia, Perth, Australia
    • ,
  • Mario Roncadin, M.D.

      Affiliations

    • Mannheim Medical Center, University of Mannheim, Mannheim, Germany
    • ,
  • Uta Kraus-Tiefenbacher, M.D.

      Affiliations

    • Department of Surgery and Radiation Oncology, Centro di Riferimento Oncologico (CRO), Aviano, Italy
    • ,
  • Frank Melchaert, M.D.

      Affiliations

    • Department of Surgery and Radiation Oncology, Centro di Riferimento Oncologico (CRO), Aviano, Italy
    • ,
  • Mohammed Keshtgar, F.R.C.S.

      Affiliations

    • Department of Surgery and Radiation Oncology, University College London, London, United Kingdom
    • ,
  • Richard Sainsbury, F.R.C.S.

      Affiliations

    • Department of Surgery and Radiation Oncology, University College London, London, United Kingdom
    • ,
  • Michael Douek, F.R.C.S.

      Affiliations

    • Department of Surgery and Radiation Oncology, University College London, London, United Kingdom
    • ,
  • Elly Harrison, B.Sc.

      Affiliations

    • Department of Surgery and Radiation Oncology, University College London, London, United Kingdom
    • ,
  • Alastair Thompson, M.D., F.R.C.S.

      Affiliations

    • Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
    • ,
  • David Joseph, M.D.

      Affiliations

    • Department of Radiation Oncology, Sir Charles Gairdner Hospital and School of Surgery and Pathology, University of Western Australia, Perth, Australia

Received 11 May 2006 ,Revised 21 July 2006 ,Accepted 27 July 2006.

References 

  1. Vaidya JS, Vyas JJ, Mittra I, et al. Multicentricity and its influence on conservative breast cancer treatment strategy. Hong Kong Int Cancer Congress. 1995;November; Abstract 44.4.
  2. Machtay M, Lanciano R, Hoffman J, et al. Inaccuracies in using the lumpectomy scar for planning electron boosts in primary breast carcinoma. Int J Radiat Oncol Biol Phys. 1994;30:43–48
  3. Sedlmayer F, Rahim HB, Kogelnik HD, et al. Quality assurance in breast cancer brachytherapy: Geographic miss in the interstitial boost treatment of the tumor bed. Int J Radiat Oncol Biol Phys. 1996;34:1133–1139
  4. Benda RK, Yasuda G, Sethi A, et al. Breast boost: Are we missing the target?. Cancer. 2003;97:905–909
  5. Vaidya JS, Baum M, Tobias JS, et al. Targeted intraoperative radiotherapy (TARGIT): An innovative method of treatment for early breast cancer. Ann Oncol. 2001;12:1075–1080
  6. Vaidya JS, Baum M, Tobias JS, et al. The novel technique of delivering targeted intraoperative radiotherapy (TARGIT) for early breast cancer. Eur J Surg Oncol. 2002;28:447–454
  7. Vaidya JS, Baum M, Tobias JS, et al. Targeted Intraoperative Radiothearpy (TARGIT)—trial protocol. Lancet. 1999;online. Available at: http://www.thelancet.com/journals/lancet/misc/protocol/99PRT-47.
  8. Vaidya JS, Joseph D, Hilaris BS, et al. Targeted intraoperative radiotherapy for breast cancer: An international trial. Abstract Book of ESTRO-21 (Prague). 2002;21:135
  9. Kraus-Tiefenbacher U, Scheda A, Steil V, et al. Intraoperative radiotherapy (IORT) for breast cancer using the Intrabeam system. Tumori. 2005;91:339–345
  10. Joseph DJ, Bydder S, Jackson LR, et al. Prospective trial of intraoperative radiation treatment for breast cancer. ANZ J Surg. 2004;74:1043–1048
  11. Vaidya JS. In: A novel approach for local treatment of early breast cancer. University of London; 2002;p. 1–242PhD thesis, May
  12. Vaidya JS, Wilson AJ, Houghton J, et al. Cosmetic outcome after targeted intraoperative radiotherapy (TARGIT) for early breast caner. Breast Cancer Res Treatment. 2003;82:1039
  13. Tobias JS, Vaidya JS, Keshtgar M, et al. Reducing radiotherapy dose in early breast cancer: The concept of conformal intraoperative brachytherapy. Br J Radiol. 2004;77:279–284
  14. Massarut S, Baldassarre G, Belletti B, et al. Intraoperative radiotherapy impairs breast cancer cell motility by surgical wound fluid. [Abstract] J Clin Oncol. 2006;24(18 suppl):10611
  15. Enderling H, Anderson AR, Chaplain MA, et al. Mathematical modelling of radiotherapy strategies for early breast cancer. J Theor Biol. 2006;241:158–171
  16. Bartelink H, Horiot JC, Poortmans P, et al. Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med. 2001;345:1378–1387

 J.S.V., M.B., and J.S.T. conceived the study.J.S.V., M.B., J.S.T., S.M., M.R., B.H., U.K., F.W., D.J., C.S., A.M.T., J.A.D. recruited and treated patients. J.S.V., M.B., J.S.T., S.M, M.R., B.H., U.K., F.W., D.J., C.S., A.M.T., J.A.D., E.H., and J.H. collected the data.M.K., R.S., M.D., and F.M. were involved in later follow-up care.J.S.V., O.M., S.M., U.K.T., T.C., and B.H. analyzed the data.J.S.V. and S.M. wrote the first draft and all other authors contributed to the final manuscript.

PII: S0360-3016(06)02754-4

doi: 10.1016/j.ijrobp.2006.07.1378

International Journal of Radiation Oncology * Biology * Physics
Volume 66, Issue 5 , Pages 1335-1338 , 1 December 2006

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