International Journal of Radiation Oncology * Biology * Physics
Volume 67, Issue 1 , Pages 164-170 , 1 January 2007

Intensity modulated radiation-therapy for preoperative posterior abdominal wall irradiation of retroperitoneal liposarcomas

Presented in part at the Forty-Seventh Annual Meeting of the American Society for Therapeutic Radiation Oncology (ASTRO), October 16–20, 2005, Denver, CO.

  • Alberto Bossi, M.D.

      Affiliations

    • Department of Radiation Oncology, University Hospitals Gasthuisberg, Leuven, Belgium
    • Corresponding Author InformationReprint requests to: Alberto Bossi, M.D., Department of Radiation Therapy, University Hospitals Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium. Tel: (+32) 16-346900
  • ,
  • Ivo De Wever, M.D., Ph.D.

      Affiliations

    • Department of Surgical Oncology, University Hospitals Gasthuisberg, Leuven, Belgium
  • ,
  • Erik Van Limbergen, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, University Hospitals Gasthuisberg, Leuven, Belgium
  • ,
  • Bianca Vanstraelen

      Affiliations

    • Department of Medical Physics, University Hospitals Gasthuisberg, Leuven, Belgium

Received 13 June 2006 ,Revised 25 July 2006 ,Accepted 16 August 2006.

References 

  1. Pisters PWT, O’Sullivan B. Retroperitoneal sarcomas: Combined modality treatment approaches. Curr Opin Oncol. 2002;14:400–405
  2. Mc Ginn CJ. The role of radiation therapy in resectable retroperitoneal sarcomas. Surg Oncol. 2000;9:61–65
  3. Porter GA, Baxter NN, Pisters PWT. Retroperitoneal sarcoma: A population based analysis of epidemiology, surgery and radiotherapy. Cancer. 2006;106:1610–1616
  4. Kilkenny J, Bland KJ, Copeland EM. Retroperitoneal sarcoma: The University of Florida experience. J Am Col Surg. 1996;182:329–339
  5. Lewis JJ, Leung D, Woodruff JM, et al. Retroperitoneal soft-tissue sarcoma: Analysis of 500 patients treated and followed at a single institution. Ann Surg. 1998;228:355–365
  6. Catton CN, O’Sullivan B, Kotwall C, et al. Outcome and prognosis in retroperitoneal soft-tissue sarcoma. Int J Radiat Oncol Biol Phys. 1994;29:1005–1010
  7. Grobmyer SR, Brennan MF. Predictive variables detailing the recurrence rate of soft tissue sarcomas. Curr Opin Oncol. 2003;15:319–326
  8. Mendenhall WM, Zlotecki RA, Hochwald SN, et al. Retroperitoneal soft tissue sarcoma. Cancer. 2005;104:669–675
  9. O’Sullivan B, Wunder J, Pisters PWT. Target description for radiotherapy of soft tissue sarcoma. In:  Gregoire V,  Scalliet P,  Ang KK editor. Clinical target volumes in conformal and intensity modulated radiation therapy. Berlin-Heidelberg: Springer-Verlag; 2004;p. 222–223
  10. Hong L, Alektiar K, Chui C, et al. IMRT of large fields: Whole-abdomen irradiation. Int J Radiat Oncol Biol Phys. 2002;54:278–289
  11. ICRU. International Commission on Radiation Units and Measurements, Prescribing, Recording and Reporting Photon Beam Therapy, ICRU Report 62 (Supplement to ICRU Report 50). 1999;
  12. Koshy M, Landry JC, Lawson JD, et al. Intensity modulated radiation therapy for retroperitoneal sarcoma: A case for dose escalation and organs at risk toxicity reduction. Sarcoma. 2003;7:137–148
  13. Scandinavian Sarcoma Group and Oncology Center, Lund, Sweden. SSG XVII Recommendations for the Diagnosis and Treatment of Abdominal, Pelvic and Retroperitoneal Sarcomas. 2002;Available at: www.ssg-org.net, Accessed: May 2006.
  14. Zagars GK, Ballo MT, Pisters PWT, et al. Prognostic factors for patients with localized soft-tissue sarcoma treated with conservative surgery and radiation therapy (An analysis of 1225 patients). Cancer. 2003;97:2530–2543
  15. Zagars GK, Goswitz MS, Pollack A. Liposarcomas: Outcome and prognostic factors following conservation surgery and radiation therapy. Int J Radiat Oncol Biol Phys. 1996;36:311–319
  16. Gilbeau L, Kantor G, Stoeckle E, et al. Surgical resection and radiotherapy for primary retroperitoneal soft tissue sarcomas. Radiother Oncol. 2002;65:137–143
  17. Pirayesh A, Chee Y, Helliwell TR, et al. The management of retroperitoneal soft tissue sarcoma: A single institution experience with a review of the literature. EJSO. 2001;27:491–497
  18. Fein DA, Corn BW, Lanciano RM, et al. Management of retroperitoneal sarcoma: Does dose escalation impact on locoregional control?. Int J Radiat Oncol Biol Phys. 1995;31:129–134
  19. Singer S, Demetri GD, Baldini EH, et al. Management of soft-tissue sarcomas: An overview and update. Lancet Oncol. 2000;1:75–85
  20. Youssef E, Fontanesi J, Mott M, et al. Long-term outcome of combined modality therapy in retroperitoneal and deep trunk soft tissue sarcoma: Analysis of prognostic factors. Int J Radiat Oncol Biol Phys. 2002;54:514–519
  21. Gieschen HL, Spiro IJ, Suit HD, et al. Long-term results of intra-operative electron beam radiotherapy for primary and recurrent retroperitoneal soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 2001;50:127–131
  22. Petersen IA, Haddock MG, Donohue JH, et al. Use of intra-operative electron beam radiotherapy in the management of retroperitoneal soft tissue sarcomas. Int J Radiat Oncol Biol Phys. 2002;52:469–475
  23. Alektiar KM, Hu K, Anderson L, et al. High-dose-rate intraoperative radiation therapy (HDR-IORT) for retroperitoneal sarcomas. Int J Radiat Oncol Biol Phys. 2000;47:157–163
  24. Krempien R, Roeder F, Oertel S, et al. Intraoperative electron-beam therapy for primary and recurrent retroperitoneal soft-tissue sarcoma. Int J Radiat Oncol Biol Phys. 2006;65:773–779
  25. Nielsen OS, O’Sullivan B. Retroperitoneal soft tissue sarcomas: A treatment challenge and a call for randomized trials. Radiother Oncol. 2002;65:133–136
  26. Jones JJ, Catton CN, O’Sullivan B, et al. Initial results of a trial of preoperative external beam radiation therapy and postoperative brachytherapy for retroperitoneal sarcoma. Ann Surg Oncol. 2002;9:346–354
  27. Pawlik TM, Pisters PWT, Mikula L, et al. Long-term results of two prospective trials of preoperative external beam radiotherapy for localized intermediate or high-grade retroperitoneal soft tissue sarcoma. Ann Surg Oncol. 2006;13:508–517
  28. Fiveash JB, Hyatt MD, Caranto J, et al. Preoperative IMRT with dose escalation to tumor subvolumes for retroperitoneal sarcomas: Initial clinical results and potential for future dose escalation [Abstract]. Int J Radiat Oncol Biol Phys. 2002;54(Suppl):140
  29. Brennan MF. Retroperitoneal sarcoma: Time for a national trial?. Ann Surg Oncol. 2002;9:324–325

 Conflict of interest: none.

PII: S0360-3016(06)02785-4

doi: 10.1016/j.ijrobp.2006.08.023

International Journal of Radiation Oncology * Biology * Physics
Volume 67, Issue 1 , Pages 164-170 , 1 January 2007