International Journal of Radiation Oncology * Biology * Physics
Volume 67, Issue 3 , Pages 828-833 , 1 March 2007

The predictive value of 2-year posttreatment biopsy after prostate cancer radiotherapy for eventual biochemical outcome

This study was presented in part at the ASTRO 2005 Annual Meeting, Denver, CO.

  • Waseet Vance, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Susan L. Tucker, Ph.D.

      Affiliations

    • Department of Biostatistics and Applied Mathematics, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Renaud de Crevoisier, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Deborah A. Kuban, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • M. Rex Cheung, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • Corresponding Author InformationReprint requests to: M. Rex Cheung, M.D., Ph.D., Department of Radiation Oncology, 1515 Holcombe Boulevard, Houston, TX 77030. Tel: (713) 563-2339; Fax: (713) 563-6940

Received 11 May 2006 ,Revised 18 September 2006 ,Accepted 18 September 2006.

References 

  1. Cox JD, Gallagher MJ, Hammond EH, et al. American Society for Therapeutic Radiology and Oncology Consensus Panel Consensus statements on radiation therapy of prostate cancer: Guidelines for prostate re-biopsy after radiation and for radiation therapy with rising prostate-specific antigen levels after radical prostatectomy. J Clin Oncol. 1999;17:1155
  2. Rosser CJ, Kuban DA, Levy LB, et al. Prostate specific antigen bounce phenomenon after external beam radiation for clinically localized prostate cancer. J Urol. 2002;168:2001–2005
  3. Cox JD, Kline RW. The lack of prognostic significance of biopsies after radiotherapy for prostatic cancer. Semin Urol. 1983;1:237–242
  4. Kuban DA, el-Mahdi AM, Schellhammer P. The significance of post-irradiation prostate biopsy with long-term follow-up. Int J Radiat Oncol Biol Phys. 1992;24:409–414
  5. Crook J, Malone S, Perry G, et al. Postradiotherapy prostate biopsies: What do they really mean? (Results for 498 patients). Int J Radiat Oncol Biol Phys. 2000;48:355–367
  6. Pollack A, Zagars GK, Antolak JA, et al. Prostate biopsy status and PSA nadir level as early surrogates for treatment failure: Analysis of a prostate cancer randomized radiation dose escalation trial. Int J Radiat Oncol Biol Phys. 2002;54:677–685
  7. Pollack A, Zagars GK, Starkschall G, et al. Prostate cancer radiation dose response: Results of the M. D. Anderson Phase III Randomized trial. Int J Radiat Oncol Biol Phys. 2002;53:1097–1105
  8. Cheung R, Tucker SL, Lee AK, et al. Dose-response characteristics of low- and intermediate-risk prostate cancer treated with external beam radiotherapy. Int J Radiat Oncol Biol Phys. 2005;61:993–1002
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  11. Roach M, Hanks G, Thames HJ, et al. Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: Recommendations of the RTOG-ASTRO Phoenix Consensus Conference. Int J Radiat Oncol Biol Phys. 2006;65:965–974
  12. Pickles T. BCCAPCO: Prostate-specific antigen (PSA) bounce and other fluctuations: Which biochemical relapse definition is least prone to PSA false calls? (An analysis of 2,030 men treated for prostate cancer with external beam or brachytherapy with or without adjuvant androgen deprivation therapy). Int J Radiat Oncol Biol Phys. 2006;64:1355–1359
  13. Levegrun S, Jackson A, Zelefsky MJ, et al. Fitting tumor control probability models to biopsy outcome after three-dimensional conformal radiation therapy of prostate cancer: Pitfalls in deducing radiobiologic parameters for tumors from clinical data. Int J Radiat Oncol Biol Phys. 2001;51:1064–1080
  14. Kestin LL, Goldstein NS, Vicini FA, et al. Pathologic evidence of dose-response and dose-volume relationships for prostate cancer treated with combined external beam radiotherapy and high-dose-rate brachytherapy. Int J Radiat Oncol Biol Phys. 2002;54:107–118
  15. Magi-Galluzzi C, Sanderson H, Epstein JI. Atypia in nonneoplastic prostate glands after radiotherapy for prostate cancer: Duration of atypia and relation to type of radiotherapy. Am J Surg Pathol. 2003;27:206–212
  16. Bostwick DG, Egbert BM, Fajardo LF. Radiation injury of the normal and neoplastic prostate. Am J Surg Pathol. 1982;6:541–551
  17. Freiha FS, Bagshaw MA. Carcinoma of the prostate: Results of post-irradiation biopsy. Prostate. 1984;5:19–25
  18. Scardino PT, Frankel JM, Wheeler TM, et al. The prognostic significance of post-irradiation biopsy results in patients with prostatic cancer. J Urol. 1986;135:510–516
  19. Shipley WU, Desilvio M, Pilepich MV, et al. Early initiation of salvage hormone therapy influences survival in patients who failed initial radiation for locally advanced prostate cancer: A secondary analysis of RTOG protocol 86–10. Int J Radiat Oncol Biol Phys. 2006;64:1162–1167
  20. Zhou P, Chen MH, McLeod D, et al. Predictors of prostate cancer-specific mortality after radical prostatectomy or radiation therapy. J Clin Oncol. 2005;23:6992–6998
  21. Pickett B, Kurhanewicz J, Coakley F, et al. Use of MRI and spectroscopy in evaluation of external beam radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2004;60:1047–1055

 Conflict of interest: none.

PII: S0360-3016(06)03048-3

doi: 10.1016/j.ijrobp.2006.09.027

International Journal of Radiation Oncology * Biology * Physics
Volume 67, Issue 3 , Pages 828-833 , 1 March 2007

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