International Journal of Radiation Oncology * Biology * Physics
Volume 67, Issue 3 , Pages 799-811 , 1 March 2007

Reduced late rectal mucosal changes after prostate three-dimensional conformal radiotherapy with endorectal balloon as observed in repeated endoscopy

  • Emile N.J.Th. van Lin, M.D.

      Affiliations

    • Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • Corresponding Author InformationReprint requests to: Emile N.J.Th. van Lin, M.D., Radboud University Nijmegen Medical Centre, Department of Radiation Oncology (874), P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Tel: (+31) 24-3614515; Fax: (+31) 24-3610792
    • ,
  • Jón Kristinsson, M.D.

      Affiliations

    • Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • Mariëlle E.P. Philippens, M.D.

      Affiliations

    • Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • Dirk J. de Jong, M.D., Ph.D.

      Affiliations

    • Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • Lisette P. van der Vight, B.Sc.

      Affiliations

    • Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • Johannes H.A.M. Kaanders, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • Jan Willem Leer, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • Andries G. Visser, Ph.D.

      Affiliations

    • Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Received 4 July 2006 ,Revised 31 August 2006 ,Accepted 19 September 2006.

References 

  1. Peeters ST, Lebesque JV, Heemsbergen WD. Localized volume effects for late rectal and anal toxicity after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2006;64:1151–1161
  2. Kupelian PA, Thakkar VV, Khuntia D, et al. Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Long-term outcomes. Int J Radiat Oncol Biol Phys. 2005;63:1463–1468
  3. Huang EH, Pollack A, Levy L, et al. Late rectal toxicity: Dose-volume effects of conformal radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2002;54:1314–1321
  4. Storey MR, Pollack A, Zagars G, et al. Complications from radiotherapy dose escalation in prostate cancer: Preliminary results of a randomized trial. Int J Radiat Oncol Biol Phys. 2000;48:635–642
  5. Tucker SL, Zhang M, Dong L, et al. Cluster model analysis of late rectal bleeding after IMRT of prostate cancer: A case-control study. Int J Radiat Oncol Biol Phys. 2006;64:1255–1264
  6. Tucker SL, Dong L, Cheung R, et al. Comparison of rectal dose-wall histogram versus dose-volume histogram for modeling the incidence of late rectal bleeding after radiotherapy. Int J Radiat Oncol Biol Phys. 2004;60:1589–1601
  7. Jackson A, Skwarchuk MW, Zelefsky MJ, et al. Late rectal bleeding after conformal radiotherapy of prostate cancer. II. Volume effects and dose-volume histograms. Int J Radiat Oncol Biol Phys. 2001;49:685–698
  8. Skwarchuk MW, Jackson A, Zelefsky MJ, et al. Late rectal toxicity after conformal radiotherapy of prostate cancer (I): Multivariate analysis and dose-response. Int J Radiat Oncol Biol Phys. 2000;47:103–113
  9. D’Amico AV, Manola J, McMahon E, et al. A prospective evaluation of rectal bleeding after dose-escalated three-dimensional conformal radiation therapy using an intrarectal balloon for prostate gland localization and immobilization. Urology. 2006;67:780–784
  10. Bastasch MD, Teh BS, Mai WY, et al. Tolerance of endorectal balloon in 396 patients treated with intensity-modulated radiation therapy (IMRT) for prostate cancer. Am J Clin Oncol. 2006;29:8–11
  11. Ronson BB, Yonemoto LT, Rossi CJ, et al. Patient tolerance of rectal balloons in conformal radiation treatment of prostate cancer. Int J Radiat Oncol Biol Phys. 2006;64:1367–1370
  12. Teh BS, Dong L, McGary JE, et al. Rectal wall sparing by dosimetric effect of rectal balloon used during intensity-modulated radiation therapy (IMRT) for prostate cancer. Med Dosim. 2005;30:25–30
  13. Woel R, Beard C, Chen MH, et al. Acute gastrointestinal, genitourinary, and dermatological toxicity during dose-escalated 3D-conformal radiation therapy (3DCRT) using an intrarectal balloon for prostate gland localization and immobilization. Int J Radiat Oncol Biol Phys. 2005;62:392–396
  14. van Lin EN, Hoffmann AL, van Kollenburg P, et al. Rectal wall sparing effect of three different endorectal balloons in 3D conformal and IMRT prostate radiotherapy. Int J Radiat Oncol Biol Phys. 2005;63:565–576
  15. Patel RR, Orton N, Tome WA, et al. Rectal dose sparing with a balloon catheter and ultrasound localization in conformal radiation therapy for prostate cancer. Radiother Oncol. 2003;67:285–294
  16. Wachter S, Gerstner N, Dorner D, et al. The influence of a rectal balloon tube as internal immobilization device on variations of volumes and dose-volume histograms during treatment course of conformal radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2002;52:91–100
  17. Teh BS, Mai WY, Uhl BM, et al. Intensity-modulated radiation therapy (IMRT) for prostate cancer with the use of a rectal balloon for prostate immobilization: Acute toxicity and dose-volume analysis. Int J Radiat Oncol Biol Phys. 2001;49:705–712
  18. O’Brien PC. Radiation injury of the rectum. Radiother Oncol. 2001;60:1–14
  19. O’Brien PC, Hamilton CS, Denham JW, et al. Spontaneous improvement in late rectal mucosal changes after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2004;58:75–80
  20. Wachter S, Gerstner N, Goldner G, et al. Endoscopic scoring of late rectal mucosal damage after conformal radiotherapy for prostatic carcinoma. Radiother Oncol. 2000;54:11–19
  21. van Lin EN, van der Vight LP, Witjes JA, et al. The effect of an endorectal balloon and off-line correction on the interfraction systematic and random prostate position variations: A comparative study. Int J Radiat Oncol Biol Phys. 2005;61:278–288
  22. D’Amico AV, Manola J, Loffredo M, et al. A practical method to achieve prostate gland immobilization and target verification for daily treatment. Int J Radiat Oncol Biol Phys. 2001;51:1431–1436
  23. Wu Q, Mohan R, Niemierko A, et al. Optimization of intensity-modulated radiotherapy plans based on the equivalent uniform dose. Int J Radiat Oncol Biol Phys. 2002;52:224–235
  24. Denham JW, O’Brien PC, Dunstan RH, et al. Is there more than one late radiation proctitis syndrome?. Radiother Oncol. 1999;51:43–53
  25. van Lin EN, Futterer JJ, Heijmink SW, et al. IMRT boost dose planning on dominant intraprostatic lesions: Gold marker-based three-dimensional fusion of CT with dynamic contrast-enhanced and 1H-spectroscopic MRI. Int J Radiat Oncol Biol Phys. 2006;65:291–303
  26. Andreyev HJ, Vlavianos P, Blake P, et al. Gastrointestinal symptoms after pelvic radiotherapy: Role for the gastroenterologist?. Int J Radiat Oncol Biol Phys. 2005;62:1464–1471
  27. Zelefsky MJ, Cowen D, Fuks Z, et al. Long term tolerance of high dose three-dimensional conformal radiotherapy in patients with localized prostate carcinoma. Cancer. 1999;85:2460–2468
  28. Teshima T, Hanks GE, Hanlon AL, et al. Rectal bleeding after conformal 3D treatment of prostate cancer: Time to occurrence, response to treatment and duration of morbidity. Int J Radiat Oncol Biol Phys. 1997;39:77–83
  29. Feigenberg SJ, Hanlon AL, Horwitz EM, et al. Long-term androgen deprivation increases Grade 2 and higher late morbidity in prostate cancer patients treated with three-dimensional conformal radiation therapy. Int J Radiat Oncol Biol Phys. 2005;62:397–405
  30. Cho KH, Lee CK, Levitt SH. Proctitis after conventional external radiation therapy for prostate cancer: Importance of minimizing posterior rectal dose. Radiology. 1995;195:699–703
  31. Lee WR, Hanks GE, Hanlon AL, et al. Lateral rectal shielding reduces late rectal morbidity following high dose three-dimensional conformal radiation therapy for clinically localized prostate cancer: Further evidence for a significant dose effect. Int J Radiat Oncol Biol Phys. 1996;35:251–257

 Conflict of interest: none.

PII: S0360-3016(06)03123-3

doi: 10.1016/j.ijrobp.2006.09.034

International Journal of Radiation Oncology * Biology * Physics
Volume 67, Issue 3 , Pages 799-811 , 1 March 2007

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