International Journal of Radiation Oncology * Biology * Physics
Volume 67, Issue 5 , Pages 1291-1298 , 1 April 2007

Prospective Trial of Accelerated Partial Breast Intensity-Modulated Radiotherapy

Presented at the Poster Discussion Session, Forty Seventh Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), October 16–20, 2005, Denver, CO, and at the International Breast Symposium, Paris, France.

  • Charles Leonard, M.D.

      Affiliations

    • Department of Radiation Oncology, Rocky Mountain Cancer Center, Littleton, CO
    • Corresponding Author InformationReprint requests to: Charles E. Leonard, M.D., Department of Radiation Oncology, Rocky Mountain Cancer Center, 22 West Dry Circle, Littleton, CO 80210. Tel: (303) 730-4700; Fax: (303) 930-8053;
  • ,
  • Dennis Carter, M.D.

      Affiliations

    • Department of Radiation Oncology, Sky Ridge Medical Center, Lone Tree, CO
  • ,
  • Jane Kercher, M.D.

      Affiliations

    • Arapahoe Surgical Associates, Littleton, CO
  • ,
  • Kathryn Howell, M.D.

      Affiliations

    • Department of Radiation Oncology, Rocky Mountain Cancer Center, Littleton, CO
  • ,
  • Phyllis Henkenberns, O.C.N.

      Affiliations

    • Department of Radiation Oncology, Rocky Mountain Cancer Center, Littleton, CO
  • ,
  • Michael Tallhamer, M.S.

      Affiliations

    • Department of Radiation Oncology, Rocky Mountain Cancer Center, Littleton, CO
  • ,
  • Patricia Cornish, C.M.D.

      Affiliations

    • Department of Radiation Oncology, Rocky Mountain Cancer Center, Littleton, CO
  • ,
  • Kari Hunter, C.M.D.

      Affiliations

    • Department of Radiation Oncology, Rocky Mountain Cancer Center, Littleton, CO
  • ,
  • Janis Kondrat, R.T.T.

      Affiliations

    • Department of Diagnostic Radiology, Sally Jobe Breast Network, Greenwood Village, CO

Received 27 July 2006 ,Revised 23 October 2006 ,Accepted 6 November 2006.

References 

  1. Fisher B, Dignam J, Wolmark N, et al. Lumpectomy and radiation therapy for the treatment of intraductal breast cancer (Findings from National Surgical Adjuvant Breast and Bowel Project B-17). J Clin Oncol. 1998;16:441–452
  2. Julien JP, Bijker N, Fentiman IS, et al. EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group Radiotherapy in breast-conserving treatment for ductal carcinoma in situ: First results of the EORTC randomised phase III trial 10853. Lancet. 2000;355:528–533
  3. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Eng J Med. 2002;347:1233–1241
  4. Veronisi U, Cascinelli N, Mariani L, Greco M, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Eng J Med. 2002;347:1227–1232
  5. Fourquet A, Campana F, Zafrani B, et al. Prognostic factors of breast recurrence in the conservative management of early breast cancer: A 25-year follow-up. Int J Radiat Oncol Biol Phys. 1989;17:719–725
  6. Boyages J, Recht A, Connolly J, et al. Early breast cancer: Predictors of breast recurrence for patients treated with conservative surgery and radiation therapy. Radiother Oncol. 1990;19:29–41
  7. Kurtz JM, Spitalier JM, Amalric R, et al. The prognostic significance of late local recurrence after breast-conserving therapy. Int J Radiat Oncol Biol Phys. 1990;18:87–93
  8. Fowble B, Solin LJ, Schultz DJ, et al. Breast recurrence following conservative surgery and radiation: Pattern of failure, prognosis, and pathologic findings from mastectomy specimens with implications for treatment. Int Radiat Oncol Biol Phys. 1990;19:833–842
  9. Clark R, McCulloch P, Levine M, et al. Randomized clinical trial to assess the effectiveness of breast irradiation following lumpectomy and axillary dissection for node negative breast cancer. J Natl Cancer Inst. 1992;84:683–689
  10. Gage I, Recht A, Gelman R, et al. Long-term outcome following breast-conserving surgery and radiation therapy. Int J Radiat Oncol Biol Phys. 1995;33:245–251
  11. Liljegren G, Holmberg L, Bergh J, et al. 10-Year results after sector resection with or without postoperative radiotherapy for stage I breast cancer: A randomized trial. J Clin Oncol. 1999;17:2326–2333
  12. Touboul E, Buffat L, Belkacemi Y, et al. Local recurrences and distant metastases after breast-conserving surgery and radiation therapy for early breast cancer. Int J Radiat Oncol Biol Phys. 1999;43:25–38
  13. Smith TE, Lee D, Turner BC, et al. True recurrence vs new primary ipsilateral breast tumor relapse: An analysis of clinical and pathologic differences and their implications in natural history, prognosis, and therapeutic management. Int J Radiat Oncol Biol Phys. 2000;48:1281–1289
  14. Veronisi U, Marubini E, Mariani L, et al. Radiotherapy after breast-conserving surgery in small breast carcinoma: Long-term results of randomized trial. Ann Oncol. 2001;12:997–1003
  15. Huang E, Bucholz TA, Meric F, et al. Classifying local disease recurrences after breast conservation therapy based on location and histology: New primary tumors have more favorable outcomes than true local disease recurrences. Cancer. 2002;95:2059–2067
  16. King TA, Bolton JS, Kuske RR, et al. Long-term results of wide-field brachytherapy as the sole method of radiation therapy after segmental mastectomy for T (is,1,2) breast cancer. Am J Surg. 2000;180:299–304
  17. Fentiman IS, Poole C, Tong D, et al. Inadequacy of iridium implant as sole radiation treatment for operable breast cancer. Eur J Cancer. 1996;32A:608–611
  18. Fentiman IS, Poole C, Tong D, et al. Iridium implant treatment without external radiotherapy for operable breast cancer: A pilot study. Eur J Cancer. 1991;27:447–450
  19. Cionini L, Pacini P, Marzano S. Exclusive brachytherapy after conservative surgery in cancer of the breast. [Abstract] Lyon Chir. 1993;89:128
  20. Krishnan L, Jewell WR, Tawfik OW, et al. Breast conservation therapy with tumor bed irradiation alone in a selected group of patients with stage I breast cancer. Breast J. 2001;7:91–96
  21. Vicini FA, Baglan KL, Kestin LL, et al. Accelerated treatment of breast cancer. J Clin Oncol. 2001;19:1993–2001
  22. Arthur DW, Koo D, Zwicker RD, et al. Partial breast brachytherapy after lumpectomy: Low-dose-rate and high-dose-rate experience. Int J Radiat Oncol Biol Phys. 2003;56:681–689
  23. Polgar C, Sulyok Z, Fodor J, et al. Sole brachytherapy of the tumor bed after conservative surgery for T1 breast cancer: Five-year results of a Phase I-II study and initial findings of a randomized Phase III trial. J Surg Oncol. 2002;80:121–128
  24. Perera F, Engel J, Holliday R, et al. Local resection and brachytherapy confined to the lumpectomy site for early breast cancer: A pilot study. J Surg Oncol. 1997;565:263–267
  25. Perera F, Chisela F, Engel J, et al. Method of localization and implantation of the lumpectomy site for high dose rate brachytherapy after conservative surgery for T1 and T2 breast cancer. Int J Radiat Oncol Biol Phys. 1995;31:959–965
  26. Baglan KL, Martinez AA, Frazier RC, et al. The use of high-dose-rate brachytherapy alone after lumpectomy in patients with early stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2001;50:1003–1011
  27. Wazer DE, Berle L, Graham R, et al. Preliminary results of a Phase I/II study of HDR brachytherapy alone for T1/T2 breast cancer. Int J Radiat Oncol Biol Phys. 2002;53:889–897
  28. Fentiman IS, Deshmane V, Tong D, et al. Caesium (137) implant as sole radiation therapy for operable breast cancer: A phase II trial. Radiother Oncol. 2004;71:281–285
  29. Veronisi U, Orecchia R, Luini A, et al. A preliminary report of intraoperative radiotherapy (IORT) in limited-stage breast cancers that are conservatively treated. Eur J Cancer. 2001;37:2178–2183
  30. Vaidya JS, Baum M, Tobias JS, et al. Targeted intra-operative (Targit): An innovative method of treatment for early breast cancer. Ann Oncol. 2001;12:1075–1080
  31. Ribeiro GG, Magee B, Swindell R, et al. The Christie Hospital breast conservation trial: An update at 8 years from inception. Clin Oncol (R Coll Radiol). 1993;5:278–283
  32. Magee B, Swindell R, Harris M, et al. Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy: Results from a randomised trial. Radiother Oncol. 1996;39:302–311
  33. Formenti SC, Rosenstein B, Skinner KA, et al. T1 stage breast cancer: Adjuvant hypofractionated conformal radiation therapy to tumor bed in selected postmenopausal breast cancer patients—Pilot feasibility study. Radiology. 2002;222:171–178
  34. Formenti SC, Truong MT, Goldberg JD, et al. Prone accelerated partial breast irradiation after breast-conserving surgery: Preliminary clinical results and dose-volume histogram analysis. Int J Radiol Oncol Biol Phys. 2004;60:493–504
  35. Baglan KL, Sharpe MB, Jaffray D, et al. Accelerated partial breast irradiation using 3D conformal radiation therapy (3D-CRT). Int J Radiat Oncol Biol Phys. 2003;55:302–311
  36. Vicini F, Remouchamps M, Wallace M, et al. Ongoing clinical experience utilizing 3D conformal external beam radiotherapy to deliver partial breast irradiation in patients with early stage breast cancer treated with breast conserving therapy (Presented at the American Society of Radiology and Oncology 47th Annual Meeting). Proc Am Soc Radiol Oncol. 2003;57:364
  37. Arthur W, Vicini FA. Accelerated partial breast irradiation as a part of breast conservation therapy. J Clin Oncol. 2003;23:1726–1735

 Conflict of interest: none.

PII: S0360-3016(06)03498-5

doi: 10.1016/j.ijrobp.2006.11.016

International Journal of Radiation Oncology * Biology * Physics
Volume 67, Issue 5 , Pages 1291-1298 , 1 April 2007