International Journal of Radiation Oncology * Biology * Physics
Volume 69, Issue 2 , Pages 475-482 , 1 October 2007

Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head and Neck Cancer

  • Leena Kankaanranta, M.D.

      Affiliations

    • Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Tiina Seppälä, Ph.D.

      Affiliations

    • Department of Physical Sciences, University of Helsinki, Helsinki, Finland
    • Boneca Corporation Ltd, Finland
    • ,
  • Hanna Koivunoro, M.Sci.

      Affiliations

    • Department of Physical Sciences, University of Helsinki, Helsinki, Finland
    • Boneca Corporation Ltd, Finland
    • ,
  • Kauko Saarilahti, M.D.

      Affiliations

    • Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Timo Atula, M.D.

      Affiliations

    • Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Juhani Collan, M.D.

      Affiliations

    • Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Eero Salli, Ph.D.

      Affiliations

    • HUS Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Mika Kortesniemi, Ph.D.

      Affiliations

    • HUS Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Jouni Uusi-Simola, M.Sci.

      Affiliations

    • Department of Physical Sciences, University of Helsinki, Helsinki, Finland
    • HUS Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Antti Mäkitie, M.D.

      Affiliations

    • Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Marko Seppänen, M.D.

      Affiliations

    • Turku PET Centre, Turku University Hospital, Turku, Finland
    • ,
  • Heikki Minn, M.D.

      Affiliations

    • Department of Oncology, Turku University Hospital, Turku, Finland
    • ,
  • Petri Kotiluoto, M.Sci.

      Affiliations

    • VTT Technical Research Centre of Finland, Espoo, Finland
    • ,
  • Iiro Auterinen, M.Sci.

      Affiliations

    • VTT Technical Research Centre of Finland, Espoo, Finland
    • ,
  • Sauli Savolainen, Ph.D.

      Affiliations

    • Department of Physical Sciences, University of Helsinki, Helsinki, Finland
    • HUS Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Mauri Kouri, M.D.

      Affiliations

    • Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Heikki Joensuu, M.D.

      Affiliations

    • Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
    • Corresponding Author InformationReprint requests to: Heikki Joensuu, M.D., Department of Oncology, Helsinki University Central Hospital, Haartmaninkatu 4, FIN-00029 Helsinki, Finland. Tel: (+358) 9-471-73208; Fax: (+358) 9-471-74202

Received 7 January 2007 ,Revised 10 March 2007 ,Accepted 12 March 2007.

References 

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  10. ICRU. ICRU report 46, photon, electron, proton, and neutron interaction data for body tissues, International Committee on Radiation Units and Measurements: Bethesda, MD; 1992.
  11. Coderre JA, Morris GM. Review: The radiation biology of boron neutron capture therapy. Rad Res. 1999;151:1–18
  12. Wheeler FJ, Nigg DW, Capala J, et al. Boron neutron capture therapy (BNCT): Implications of neutron beam and boron compound characteristics. Med Phys. 1999;26:1237–1244
  13. Ryynänen PM, Kortesniemi M, Coderre JA, et al. Models for estimation of the (10)B concentration after BPA-fructose complex infusion in patients during epithermal neutron irradiation in BNCT. Int J Radiat Oncol Biol Phys. 2000;48:1145–1154
  14. Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 2000;92:205–216
  15. Milano MT, Vokes EE, Salama JK, et al. Twice-daily reirradiation for recurrent and second primary head-and-neck cancer with gemcitabine, paclitaxel, and 5-fluorouracil chemotherapy. Int J Radiat Oncol Biol Phys. 2005;61:1096–1106
  16. Salama JK, Vokes EE, Chmura SJ, et al. Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2006;64:382–391
  17. Kouri M, Kankaanranta L, Seppälä T, et al. Undifferentiated sinonasal carcinoma may respond to single-fraction boron neutron capture therapy. Radiother Oncol. 2004;72:83–85
  18. Aihara T, Hiratsuka J, Morita N, et al. First clinical case of boron neutron capture therapy for head and neck malignant. Head and Neck. 2006;28:850–855
  19. Kato I, Ono K, Sakurai Y, et al. Effectiveness of BNCT for recurrent head and neck malignancies. Appl Radiat Isot. 2004;61:1069–1073
  20. Aihara T, Hiratsuka J, Nishiike S, et al. Using BPA alone for boron neutron capture therapy of recurrent head and neck malignancies. In: Nagakawa Y, Kobayashi T, Fukuda H, editors. Proceedings 12th International Congress on Neutron Capture Therapy, Takamatsu, Japan, October 9–12, 2006. p. 5–6.
  21. Ariyoshi Y, Shimahara M, Kimura Y, et al. Boron neutron capture therapy for advanced and/or recurrent cancers in the oral cavity. In: Nagakawa Y, Kobayashi T, Fukuda H, editors. Proceedings 12th International Congress on Neutron Capture Therapy, Takamatsu, Japan. October 9–12, 2006. p. 10–13.
  22. Chadha M, Capala J, Coderre JA, et al. Boron neutron-capture therapy (BNCT) for glioblastoma multiforme (GBM) using the epithermal neutron beam at the Brookhaven National Laboratory. Int J Radiat Oncol Biol Phys. 1998;40:829–834

 Presented at the 12th International Congress on Neutron Capture Therapy, Takamatsu, Kagawa, Japan, October 9–13, 2006.

 Supported by grants from the Academy of Finland and Helsinki University Central Hospital research funds. L.K., T.S., H.K., J.C., M. Kortesniemi, J.U.-S., S.S., and M. Kouri have received financial compensation from Boneca Corporation Ltd for the work done to treat BNCT patients. H.J. has received financial compensation from Boneca Corporation Ltd for consultations. H.K. is an employee of Boneca Corporation Ltd.

PII: S0360-3016(07)00555-X

doi: 10.1016/j.ijrobp.2007.03.039

International Journal of Radiation Oncology * Biology * Physics
Volume 69, Issue 2 , Pages 475-482 , 1 October 2007

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