International Journal of Radiation Oncology * Biology * Physics
Volume 69, Issue 4 , Pages 1187-1192 , 15 November 2007

A Contribution to Solve the Problem of the Need for Consolidative Radiotherapy after Intensive Chemotherapy in Advanced Stages of Hodgkin's Lymphoma—Analysis of a Quality Control Program Initiated by the Radiotherapy Reference Center of the German Hodgkin Study Group (GHSG)

  • Hans Theodor Eich, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of Cologne, Cologne, Germany
    • Corresponding Author InformationReprint requests to: Hans Theodor Eich, M.D., Ph.D., Department of Radiation Oncology, University of Cologne, Joseph-Stelzmann Str. 9, D-50924 Köln, Germany. Tel: (+49) 221-478-5449; Fax: (+49) 221-478-6158
    • ,
  • Axel Gossmann, M.D.

      Affiliations

    • Department of Radiology, University of Cologne, Cologne, Germany
    • ,
  • Andreas Engert, M.D.

      Affiliations

    • Department of Medical Oncology, University of Cologne, Cologne, Germany
    • ,
  • Jan Kriz, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Cologne, Cologne, Germany
    • ,
  • Henning Bredenfeld, M.D.

      Affiliations

    • Department of Medical Oncology, University of Cologne, Cologne, Germany
    • ,
  • Katja Hansemann, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Cologne, Cologne, Germany
    • ,
  • Roman Skripnitchenko, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Cologne, Cologne, Germany
    • ,
  • Corinne Brillant, Ph.D.

      Affiliations

    • Department of Medical Oncology, University of Cologne, Cologne, Germany
    • ,
  • Beate Pfistner, Ph.D.

      Affiliations

    • Department of Medical Oncology, University of Cologne, Cologne, Germany
    • ,
  • Susanne Staar, M.D.

      Affiliations

    • Department of Radiation Oncology, Klinikum Bremen Mitte, Bremen, Germany
    • ,
  • Volker Diehl, M.D.

      Affiliations

    • Department of Medical Oncology, University of Cologne, Cologne, Germany
    • ,
  • Rolf-Peter Müller, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Cologne, Cologne, Germany

Received 7 March 2007 ,Revised 16 April 2007 ,Accepted 16 April 2007.

References 

  1. Yung L, Linch D. Hodgkin's lymphoma. Lancet. 2003;361:943–951
  2. Canellos GP, Anderson JR, Propert KJ, et al. Chemotherapy of advanced Hodgkin's disease with MOPP, ABVD, or MOPP alternating with ABVD. N Engl J Med. 1992;327:1478–1484
  3. Diehl V, Sieber M, Rüffer U, et al. BEACOPP, a new intensified chemotherapy regimen in advanced Hodgkin's disease. Ann Oncol. 1997;8:143–148
  4. Diehl V, Tesch H, Lathan B, et al. BEACOPP, a new intensified hybrid regimen, is at least equally effective compared with COPP/ABVD in patients with advanced stage Hodgkin's disease. Proc Am Soc Oncol. 1997;16:2a
  5. Diehl V, Franklin J, Pfreundschuh M, et al. Standard and increased-dose BEACOPP chemotherapy compared with COPP-ABVD for advanced Hodgkin's disease. N Engl J Med. 2003;348:2386–2395
  6. Horning S, Hoppe R, Breslin S, et al. Stanford V and radiotherapy for locally extensive and advanced Hodgkin's disease: Mature results of a prospective clinical trial. J Clin Oncol. 2002;20:630–637
  7. Loeffler M, Brosteanu O, Hasenclever D, et al. Meta-analysis of chemotherapy versus combined modality treatment trials in Hodgkin's disease. J Clin Oncol. 1998;16:818–829
  8. Aleman BMP, Raemaekers J, Tirelli U, et al. Involved-field radiotherapy for advanced Hodgkin's lymphoma. N Engl J Med. 2003;348:2396–2406
  9. Eich HT, Staar S, Gossmann A, et al. The HD12 Panel of the German Hodgkin Lymphoma Study Group (GHSG)–a quality assurance program based on a multidisciplinary panel reviewing all patients' imaging. Am J Clin Oncol. 2004;27:279–284
  10. Carbone PP, Kaplan HS, Musshoff K, et al. Report of the committee of Hodgkin's disease staging classification. Cancer Res. 1971;31:1860–1861
  11. Lister TA, Crowther D, Sutcliffe SB, et al. Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin's disease. Cotswolds Meeting. J Clin Oncol. 1989;7:1630–1636
  12. Eich HT, Müller R-P, Schneeweiss A, et al. Initiation of a teleradiotherapeutic network for patients in German lymphoma studies. Int J Radiat Oncol Biol Phys. 2004;58:805–808
  13. Bundesärztekammer . Leitlinien der Bundesärztekammer zur Qualitätssicherung in der Computertomographie. Dt Ärztebl. 1992;89:3–11
  14. Bundesausschuss der Ärzte und Krankenkassen . Richtlinien des Bundesausschusses der Ärzte und Krankenkassen über Kriterien zur Qualitätsbeurteilung in der radiologischen Diagnostik gemäss § 136 SGB V in der Fassung vom 17. 6. 1992, zuletzt geändert am 17.12.1996. Dt Ärztebl. 1997;94:581–588
  15. Longo D, Young R, Wesles M, et al. Twenty years of MOPP chemotherapy for Hodgkin's disease. J Clin Oncol. 1986;4:1295–1306
  16. van Leeuwen F, Klokman W, Veer M, et al. Long-term risk of second malignancy in survivors of Hodgkin's disease treated during adolescence or young adulthood. J Clin Oncol. 2000;18:487–497
  17. Eich HT, Staar S, Gossmann A, et al. Centralized radiation oncological review of cross-sectional imaging of Hodgkin's disease leads to significant changes of the required involved field—results of a quality assurance program of the German Hodgkin Study Group (GHSG). Int J Radiat Oncol Biol Phys. 2004;58:1121–1127
  18. Dühmke E, Franklin J, Pfreundschuh M, et al. Low-dose radiation is sufficient for the noninvolved extended field treatment in favorable early-stage Hodgkin's disease: Long-term results of a randomized trial of radiotherapy alone. J Clin Oncol. 2001;19:2905–2914
  19. Aleman BMP, Girinsky T, van Der Maazen RWM, et al. Quality control of involved-field radiotherapy in patients with advanced Hodgkin's lymphoma (EORTC 20884). Int J Radiat Oncol Biol Phys. 2005;63:1184–1190

 Presented at the 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), Philadelphia, PA, Nov 5–9, 2006.

 Supported by the “Competence Network Malignant Lymphoma” Federal German Ministry of Education and Research and the “Deutsche Krebshilfe.”

 Conflict of interest: none.

PII: S0360-3016(07)00702-X

doi: 10.1016/j.ijrobp.2007.04.035

International Journal of Radiation Oncology * Biology * Physics
Volume 69, Issue 4 , Pages 1187-1192 , 15 November 2007

Article Tools

* Image Usage & Resolution