International Journal of Radiation Oncology * Biology * Physics
Volume 69, Issue 1 , Pages 230-239 , 1 September 2007

Principal Component Analysis-Based Pattern Analysis of Dose–Volume Histograms and Influence on Rectal Toxicity

  • Matthias Söhn, Dipl.Phys.

      Affiliations

    • Section of Biomedical Physics, University Hospital for Radiation Oncology, Tübingen, Germany
    • Corresponding Author InformationReprint requests to: Matthias Söhn, Dipl.Phys., Section of Biomedical Physics, University Hospital for Radiation Oncology, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany. Tel: (++49) 7071-2986061; Fax: (++49) 7071-295920
    • ,
  • Markus Alber, Ph.D.

      Affiliations

    • Section of Biomedical Physics, University Hospital for Radiation Oncology, Tübingen, Germany
    • ,
  • Di Yan, D.Sc.

      Affiliations

    • Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI

Received 20 September 2006 ,Revised 14 February 2007 ,Accepted 14 April 2007.

References 

  1. Boersma LJ, van den Brink M, Bruce AM, et al. Estimation of the incidence of late bladder and rectum complications after high-dose (70–78 Gy) conformal radiotherapy for prostate cancer, using dose–volume histograms. Int J Radiat Oncol Biol Phys. 1998;41:83–92
  2. Jackson A, Skwarchuk MW, Zelefsky MJ, et al. Late rectal bleeding after conformal radiotherapy of prostate cancer (II): Volume effects and dose–volume histograms. Int J Radiat Oncol Biol Phys. 2001;49:685–698
  3. Rancati T, Fiorino C, Gagliardi G, et al. Fitting late rectal bleeding data using different NTCP models: Results from an Italian multi-centric study (AIROPROS0101). Radiother Oncol. 2004;73:21–32
  4. Söhn M, Yan D, Liang J, et al. Incidence of late rectal bleeding in high-dose conformal radiotherapy of prostate cancer using equivalent uniform dose-based and dose-volume-based normal tissue complication probability models. Int J Radiat Oncol Biol Phys 2007;67:1066–1073.
  5. Skwarchuk MW, Jackson A, Zelefsky MJ, et al. Late rectal toxicity after conformal radiotherapy of prostate cancer (I): Multivariate analysis and dose-response. Int J Radiat Oncol Biol Phys. 2000;47:103–113
  6. Tucker SL, Cheung R, Dong L, et al. Dose–volume response analysis of late rectal bleeding after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2004;59:353–365
  7. Vargas C, Martinez A, Kestin LL, et al. Dose–volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapy. Int J Radiat Oncol Biol Phys. 2005;62:1297–1308
  8. Zapatero A, García-Vicente F, Modolell I, et al. Impact of mean rectal dose on late rectal bleeding after conformal radiotherapy for prostate cancer: Dose–volume effect. Int J Radiat Oncol Biol Phys. 2004;59:1343–1351
  9. Kutcher GJ, Burman C. Calculation of complication probability factors for non-uniform normal tissue irradiation: The effective volume method. Int J Radiat Oncol Biol Phys. 1989;16:1623–1630
  10. Haken RKT, Martel MK, Kessler ML, et al. Use of Veff and iso-NTCP in the implementation of dose escalation protocols. Int J Radiat Oncol Biol Phys. 1993;27:689–695
  11. Niemierko A. Reporting and analyzing dose distributions: A concept of equivalent uniform dose. Med Phys. 1997;24:103–110
  12. Niemierko A. A generalized concept of equivalent uniform dose. [Abstract] Med Phys. 1999;26:1100
  13. Dawson LA, Biersack M, Lockwood G, et al. Use of principal component analysis to evaluate the partial organ tolerance of normal tissues to radiation. Int J Radiat Oncol Biol Phys. 2005;62:829–837
  14. Bauer JD, Jackson A, Skwarchuk M, et al. Principal component analysis as applied to volume effects in treatment outcomes for patients with prostate cancer treated with 3D-CRT. [Abstract] Med Phys. 2004;31:1910
  15. Bauer JD, Jackson A, Skwarchuk M, et al. Principal component, Varimax rotation and cost analysis of volume effects in rectal bleeding in patients treated with 3D-CRT for prostate cancer. Phys Med Biol. 2006;51:5105–5123
  16. Vargas C, Yan D, Kestin LL, et al. Phase II dose escalation study of image-guided adaptive radiotherapy for prostate cancer: Use of dose–volume constraints to achieve rectal isotoxicity. Int J Radiat Oncol Biol Phys. 2005;63:141–149
  17. Martinez AA, Yan D, Lockman D, et al. Improvement in dose escalation using the process of adaptive radiotherapy combined with three-dimensional conformal or intensity-modulated beams for prostate cancer. Int J Radiat Oncol Biol Phys. 2001;50:1226–1234
  18. Yan D, Lockman D, Brabbins D, et al. An off-line strategy for constructing a patient-specific planning target volume in adaptive treatment process for prostate cancer. Int J Radiat Oncol Biol Phys. 2000;48:289–302
  19. National Cancer Institute Common Terminology Criteria for Adverse Events v3.0 (CTCAE). Available at http://ctep.cancer.gov/reporting/ctc_v30.html. Accessed January 15, 2007.
  20. Pekar V, McNutt TR, Kaus MR. Automated model-based organ delineation for radiotherapy planning in prostatic region. Int J Radiat Oncol Biol Phys. 2004;60:973–980
  21. Söhn M, Birkner M, Yan D, et al. Modelling individual geometric variation based on dominant eigenmodes of organ deformation: Implementation and evaluation. Phys Med Biol. 2005;50:5893–5908
  22. Cox DR, Snell EJ. Analysis of binary data. 2nd ed.. London: Chapman & Hall; 1989;
  23. Jackson A, Haken RKT, Robertson JM, et al. Analysis of clinical complication data for radiation hepatitis using a parallel architecture model. Int J Radiat Oncol Biol Phys. 1995;31:883–891
  24. Akaike H. Information theory and an extension of the maximum likelihood principle. In:  Petrov BN,  Csaki F editor. Second international symposium on information theory. Budapest: Academiai Kaido; 1973;p. 267–281
  25. Akaike H. A new look at statistical model identification. IEEE Trans Autom Control. 1974;19:716–723
  26. Press WH, Flannery BP, Teukolsky SA, et al. Numerical recipes in C: The art of scientific computing. 2nd ed.. Cambridge: Cambridge University Press; 1992;

 Supported in part by Deutsche Krebshilfe e.V. Grant 106280 and National Institutes of Health Grant RO1 CA091020.Presented in part at the 47th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), Denver, CO, October 16–20, 2005.Conflict of interest: none.

PII: S0360-3016(07)00795-X

doi: 10.1016/j.ijrobp.2007.04.066

International Journal of Radiation Oncology * Biology * Physics
Volume 69, Issue 1 , Pages 230-239 , 1 September 2007

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