Outcomes in Treatment for Intradural Spinal Cord Ependymomas
Received 20 March 2007; received in revised form 24 April 2007; accepted 25 April 2007. published online 07 August 2007.
Purpose
Spinal cord ependymomas are rare tumors, accounting for <2% of all primary central nervous system tumors. This study assessed the treatment outcomes for patients diagnosed with spinal cord ependymomas within the Southern California Kaiser Permanente system.
Methods and Materials
We studied 23 patients treated with surgery with or without external beam radiotherapy (EBRT). The local and distant control rates and overall survival rates were determined.
Results
The overall local control, overall recurrence, and 9-year overall survival rate was 96%, 17.4%, and 63.9%, respectively.
Conclusions
The results of our study indicate that en bloc gross total resection should be the initial treatment, with radiotherapy reserved primarily for postoperative cases with unfavorable characteristics such as residual tumor, anaplastic histologic features, or piecemeal resection. Excellent local control and overall survival rates can be achieved using modern microsurgical techniques, with or without local radiotherapy.
Reprint requests to: P. Brian Volpp, M.D., M.P.H., Department of Radiation Oncology, Southern California Permanente Medical Group, 4950 Sunset Blvd., 2nd Fl., Los Angeles, CA 90027. Tel: (323) 783-2886; Fax: (323) 783-5927
ABSTRACT