International Journal of Radiation Oncology * Biology * Physics
Volume 70, Issue 3 , Pages 735-743 , 1 March 2008

Role of Adjuvant Chemoradiation Therapy in Adenocarcinomas of the Ampulla of Vater

  • Sunil Krishnan, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • Corresponding Author InformationReprint requests to: Sunil Krishnan, M.D., Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4009. Tel: (713) 563-2377; Fax: (713) 563-2366
    • ,
  • Vishal Rana, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Douglas B. Evans, M.D.

      Affiliations

    • Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Gauri Varadhachary, M.D.

      Affiliations

    • Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Prajnan Das, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Sumita Bhatia, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Marc E. Delclos, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Nora A. Janjan, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Robert A. Wolff, M.D.

      Affiliations

    • Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Christopher H. Crane, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Peter W. Pisters, M.D.

      Affiliations

    • Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Received 21 May 2007 ,Revised 2 July 2007 ,Accepted 4 July 2007.

References 

  1. Brennan MF. Surgical management of peripancreatic cancer. Philadelphia: W.B. Saunders; 1995;
  2. Yeo CJ, Sohn TA, Cameron JL, et al. Periampullary adenocarcinoma: Analysis of 5-year survivors. Ann Surg. 1998;227:821–831
  3. Whipple AO. A reminiscence: Pancreaticoduodenectomy. Rev Surg. 1963;20:221–225
  4. Klempnauer J, Ridder GJ, Pichlmayr R. Prognostic factors after resection of ampullary carcinoma: Multivariate survival analysis in comparison with ductal cancer of the pancreatic head. Br J Surg. 1995;82:1686–1691
  5. Kopelson G. Curative surgery for adenocarcinoma of the pancreas/ampulla of Vater: the role of adjuvant pre or postoperative radiation therapy. Int J Radiat Oncol Biol Phys. 1983;9:911–915
  6. Kopelson G, Galdabini J, Warshaw AL, et al. Patterns of failure after curative surgery for extra-hepatic biliary tract carcinoma: Implications for adjuvant therapy. Int J Radiat Oncol Biol Phys. 1981;7:413–417
  7. Bhatia S, Miller RC, Haddock MG, et al. Adjuvant therapy for ampullary carcinomas: The Mayo Clinic experience. Int J Radiat Oncol Biol Phys. 2006;66:514–519
  8. Czito BG, Clough R, Pappas T, et al. Carcinoma of the ampulla of Vater: Patterns of failure after resection and possible benefit of adjuvant radiotherapy. Int J Radiat Oncol Biol Phys. 2005;63:S166–S167
  9. Lee JH, Whittington R, Williams NN, et al. Outcome of pancreaticoduodenectomy and impact of adjuvant therapy for ampullary carcinomas. Int J Radiat Oncol Biol Phys. 2000;47:945–953
  10. Mehta VK, Fisher GA, Ford JM, et al. Adjuvant chemoradiotherapy for “unfavorable” carcinoma of the ampulla of Vater: Preliminary report. Arch Surg. 2001;136:65–69
  11. Sikora SS, Balachandran P, Dimri K, et al. Adjuvant chemo-radiotherapy in ampullary cancers. Eur J Surg Oncol. 2005;31:158–163
  12. Kaplan E, Meier P. Non-parametric estimation for incomplete observations. J Am Stat Assoc. 1958;53:457–481
  13. Cox DR. Regression models and life tables. [with discussion] J R Stat Soc Ser B. 1972;34:187–220
  14. Peto R, Peto J. Asymptotically efficient rank invariant procedures (with discussion). J R Stat Soc. 1972;Series A 135:85–207
  15. Willett CG, Warshaw AL, Convery K, et al. Patterns of failure after pancreaticoduodenectomy for ampullary carcinoma. Surg Gynecol Obstet. 1993;176:33–38
  16. Klinkenbijl JH, Jeekel J, Sahmoud T, et al. Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: Phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg. 1999;230:776–782discussion 82–84
  17. Pisters PW, Abbruzzese JL, Janjan NA, et al. Rapid-fractionation preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for resectable pancreatic adenocarcinoma. J Clin Oncol. 1998;16:3843–3850
  18. Spitz FR, Abbruzzese JL, Lee JE, et al. Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas. J Clin Oncol. 1997;15:928–937
  19. American Joint Committee on Cancer . AJCC Cancer Staging Handbook. Vol 6. New York: Springer-Verlag; 2002;
  20. Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351:1731–1740

 Presented in part at the 2006 American Society of Clinical Oncology Gastrointestinal Cancers Symposium, January 26–28, 2006, San Francisco, CA.

 Conflict of interest: none.

PII: S0360-3016(07)03672-3

doi: 10.1016/j.ijrobp.2007.07.2327

International Journal of Radiation Oncology * Biology * Physics
Volume 70, Issue 3 , Pages 735-743 , 1 March 2008

Article Tools

* Image Usage & Resolution