International Journal of Radiation Oncology * Biology * Physics
Volume 69, Issue 5 , Pages 1593-1599 , 1 December 2007

Combined Photon and Electron Three-Dimensional Conformal Versus Intensity-Modulated Radiotherapy With Integrated Boost for Adjuvant Treatment of Malignant Pleural Mesothelioma After Pleuropneumonectomy

  • Jerôme Krayenbuehl, Dipl.Phys. E.T.H.

      Affiliations

    • Department of Radiation Oncology, Zurich University Hospital, Zurich, Switzerland
    • ,
  • Susanne Oertel, M.D.

      Affiliations

    • Department of Radiation Oncology, Zurich University Hospital, Zurich, Switzerland
    • ,
  • J. Bernard Davis, Ph.D.

      Affiliations

    • Department of Radiation Oncology, Zurich University Hospital, Zurich, Switzerland
    • ,
  • I. Frank Ciernik, M.D.

      Affiliations

    • Center for Clinical Research, Zurich University Hospital, Zurich, Switzerland
    • Oncology Institute of Southern Switzerland, Ospedale San Giovanni e Valli, Bellinzona, Switzerland
    • Corresponding Author InformationReprint requests to: I. Frank Ciernik, M.D., Istituto Oncologico della Svizzera Italiana, Bellinzona 6500, Switzerland. Tel: (+41) 91-811-9157; Fax: (+41) 91-811-8678

Received 24 February 2007 ,Revised 30 July 2007 ,Accepted 30 July 2007.

References 

  1. Stevens CW, Forster KM, Smythe WR, et al. Radiotherapy for mesothelioma. Hematol Oncol Clin North Am. 2005;19:1099–1115vii
  2. Kong FM, Zhao L, Hayman JA. The role of radiation therapy in thoracic tumors. Hematol Oncol Clin North Am. 2006;20:363–400
  3. de Graaf-Strukowska L, van der Zee J, van Putten W, et al. Factors influencing the outcome of radiotherapy in malignant mesothelioma of the pleura—A single-institution experience with 189 patients. Int J Radiat Oncol Biol Phys. 1999;43:511–516
  4. Boutin C, Rey F, Viallat JR. Prevention of malignant seeding after invasive diagnostic procedures in patients with pleural mesothelioma: A randomized trial of local radiotherapy. Chest. 1995;108:754–758
  5. Sugarbaker DJ, Flores RM, Jaklitsch MT, et al. Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: Results in 183 patients. J Thorac Cardiovasc Surg. 1999;117:54–65
  6. Holsti LR, Pyrhonen S, Kajanti M, et al. Altered fractionation of hemithorax irradiation for pleural mesothelioma and failure patterns after treatment. Acta Oncol. 1997;36:397–405
  7. Weder W, Kestenholz P, Taverna C, et al. Neoadjuvant chemotherapy followed by extrapleural pneumonectomy in malignant pleural mesothelioma. J Clin Oncol. 2004;22:3451–3457
  8. Steel J. Prognostic factors in mesothelioma. Semin Oncol. 2002;29:36–40
  9. Opitz I, Kestenholz P, Lardinois D, et al. Incidence and management of complications after neoadjuvant chemotherapy followed by extrapleural pneumonectomy for malignant pleural mesothelioma. Eur J Cardiothorac Surg. 2006;29:579–584
  10. Yajnik S, Rosenzweig KE, Mychalczak B, et al. Hemithoracic radiation after extrapleural pneumonectomy for malignant pleural mesothelioma. Int J Radiat Oncol Biol Phys. 2003;56:1319–1326
  11. Gupta V, Mychalczak B, Krug L, et al. Hemithoracic radiation therapy after pleurectomy/decortication for malignant pleural mesothelioma. Int J Radiat Oncol Biol Phys. 2005;63:1045–1052
  12. Kutcher GJ, Kestler C, Greenblatt D, et al. Technique for external beam treatment for mesothelioma. Int J Radiat Oncol Biol Phys. 1987;13:1747–1752
  13. Stevens CW, Wong PF, Rice D, et al. Treatment planning system evaluation for mesothelioma IMRT. Lung Cancer. 2005;49:S75–S81
  14. Munter MW, Thieke C, Nikoghosyan A, et al. Inverse planned stereotactic intensity modulated radiotherapy (IMRT) in the palliative treatment of malignant mesothelioma of the pleura: The Heidelberg experience. Lung Cancer. 2005;49:S83–S86
  15. Ahamad A, Stevens CW, Smythe WR, et al. Intensity-modulated radiation therapy: A novel approach to the management of malignant pleural mesothelioma. Int J Radiat Oncol Biol Phys. 2003;55:768–775
  16. Allen AM, Czerminska M, Janne PA, et al. Fatal pneumonitis associated with intensity-modulated radiation therapy for mesothelioma. Int J Radiat Oncol Biol Phys. 2006;65:640–645
  17. Kwa SL, Lebesque JV, Theuws JC, et al. Radiation pneumonitis as a function of mean lung dose: An analysis of pooled data of 540 patients. Int J Radiat Oncol Biol Phys. 1998;42:1–9
  18. Oetzel D, Schraube P, Hensley F, et al. Estimation of pneumonitis risk in three-dimensional treatment planning using dose–volume histogram analysis. Int J Radiat Oncol Biol Phys. 1995;33:455–460
  19. Yorke ED, Jackson A, Rosenzweig KE, et al. Correlation of dosimetric factors and radiation pneumonitis for non–small-cell lung cancer patients in a recently completed dose escalation study. Int J Radiat Oncol Biol Phys. 2005;63:672–682
  20. Wang SL, Liao Z, Vaporciyan AA, et al. Investigation of clinical and dosimetric factors associated with postoperative pulmonary complications in esophageal cancer patients treated with concurrent chemoradiotherapy followed by surgery. Int J Radiat Oncol Biol Phys. 2006;64:692–699
  21. Chan MF, Chui CS, Song Y, et al. A novel radiation therapy technique for malignant pleural mesothelioma combining electrons with intensity-modulated photons. Radiother Oncol. 2006;79:218–223

 Supported by the Radium Fund, University of Zurich, Switzerland to I. F. Ciernik.

 Conflict of interest: none.

PII: S0360-3016(07)03862-X

doi: 10.1016/j.ijrobp.2007.07.2370

International Journal of Radiation Oncology * Biology * Physics
Volume 69, Issue 5 , Pages 1593-1599 , 1 December 2007

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