International Journal of Radiation Oncology * Biology * Physics
Volume 70, Issue 4 , Pages 993-1001, 15 March 2008

A Phase I Dose-Escalation Study of Fractionated Stereotactic Radiosurgery in Combination With Gefitinib in Patients With Recurrent Malignant Gliomas

  • Amanda L. Schwer, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO
    • ,
  • Denise M. Damek, M.D.

      Affiliations

    • Department of Medical Oncology, University of Colorado Health Sciences Center, Aurora, CO
    • ,
  • Brian D. Kavanagh, M.D., M.P.H.

      Affiliations

    • Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO
    • ,
  • Laurie. E. Gaspar, M.D., M.B.A.

      Affiliations

    • Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO
    • ,
  • Kevin Lillehei, M.D.

      Affiliations

    • Department of Neurosurgery, University of Colorado Health Sciences Center, Aurora, CO
    • ,
  • Kelly Stuhr, M.S.

      Affiliations

    • Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO
    • ,
  • Changhu Chen, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO
    • Corresponding Author InformationReprint requests to Changhu Chen, M.D., Department of Radiation Oncology, University of Colorado Health Sciences Center, 1665 North Ursula Street, Suite 1032, Mail Stop F-706, P.O. Box 6510, Aurora, CO 80045-0508; Tel: (720)-848-0116; Fax: (720)-848-0222

Received 20 June 2007; received in revised form 23 July 2007; accepted 27 July 2007. published online 29 October 2007.

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 The preliminary results of this study were presented at the 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), November 5–9, 2006, Philadelphia, PA

 AstraZeneca Pharmaceuticals Inc. provided study drug gefitinib and partial funding.

 Conflict of interest: none.

PII: S0360-3016(07)03912-0

doi:10.1016/j.ijrobp.2007.07.2382

International Journal of Radiation Oncology * Biology * Physics
Volume 70, Issue 4 , Pages 993-1001, 15 March 2008

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